Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants
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Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants. / Didié, Michael; Biermann, Daniel; Buchert, Ralph; Hess, Andreas; Wittköpper, Katrin; Christalla, Peter; Döker, Stephan; Jebran, Fawad; Schöndube, Friedrich; Reichenspurner, Hermann; El-Armouche, Ali; Zimmermann, Wolfram-Hubertus.
In: AM J PHYSIOL-HEART C, Vol. 305, No. 4, 15.08.2013, p. 533-541.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants
AU - Didié, Michael
AU - Biermann, Daniel
AU - Buchert, Ralph
AU - Hess, Andreas
AU - Wittköpper, Katrin
AU - Christalla, Peter
AU - Döker, Stephan
AU - Jebran, Fawad
AU - Schöndube, Friedrich
AU - Reichenspurner, Hermann
AU - El-Armouche, Ali
AU - Zimmermann, Wolfram-Hubertus
PY - 2013/8/15
Y1 - 2013/8/15
N2 - Total mechanical unloading of the heart in classical models of heterotopic heart transplantation leads to cardiac atrophy and functional deterioration. In contrast, partial unloading of failing human hearts with left ventricular (LV) assist devices (LVADs) can in some patients ameliorate heart failure symptoms. Here we tested in heterotopic rat heart transplant models whether partial volume-loading (VL; anastomoses: aorta of donor to aorta of recipient, pulmonary artery of donor to left atrium of donor, superior vena cava of donor to inferior vena cava of recipient; n = 27) is superior to the classical model of myocardial unloading (UL; anastomoses: aorta of donor to aorta of recipient, pulmonary artery of donor to inferior vena cava of recipient; n = 14) with respect to preservation of ventricular morphology and function. Echocardiography, magnetic resonance imaging, and LV-pressure-volume catheter revealed attenuated myocardial atrophy with ~30% higher LV weight and better systolic contractile function in VL compared with UL (fractional area shortening, 34% vs. 18%; maximal change in pressure over time, 2,986 ± 252 vs. 2,032 ± 193 mmHg/s). Interestingly, no differences in fibrosis (Picrosirus red staining) or glucose metabolism (2-[18F]-fluoro-2-deoxy-D-glucose-PET) between VL and UL were observed. We conclude that the rat model of partial VL attenuates atrophic remodelling and shows superior morphological as well as functional preservation, and thus should be considered more widely as a research model.
AB - Total mechanical unloading of the heart in classical models of heterotopic heart transplantation leads to cardiac atrophy and functional deterioration. In contrast, partial unloading of failing human hearts with left ventricular (LV) assist devices (LVADs) can in some patients ameliorate heart failure symptoms. Here we tested in heterotopic rat heart transplant models whether partial volume-loading (VL; anastomoses: aorta of donor to aorta of recipient, pulmonary artery of donor to left atrium of donor, superior vena cava of donor to inferior vena cava of recipient; n = 27) is superior to the classical model of myocardial unloading (UL; anastomoses: aorta of donor to aorta of recipient, pulmonary artery of donor to inferior vena cava of recipient; n = 14) with respect to preservation of ventricular morphology and function. Echocardiography, magnetic resonance imaging, and LV-pressure-volume catheter revealed attenuated myocardial atrophy with ~30% higher LV weight and better systolic contractile function in VL compared with UL (fractional area shortening, 34% vs. 18%; maximal change in pressure over time, 2,986 ± 252 vs. 2,032 ± 193 mmHg/s). Interestingly, no differences in fibrosis (Picrosirus red staining) or glucose metabolism (2-[18F]-fluoro-2-deoxy-D-glucose-PET) between VL and UL were observed. We conclude that the rat model of partial VL attenuates atrophic remodelling and shows superior morphological as well as functional preservation, and thus should be considered more widely as a research model.
KW - Anastomosis, Surgical
KW - Animals
KW - Aorta/physiopathology
KW - Atrophy
KW - Cardiac Catheterization
KW - Echocardiography
KW - Fibrosis
KW - Heart Transplantation/adverse effects
KW - Heart-Assist Devices
KW - Hemodynamics
KW - Magnetic Resonance Imaging
KW - Male
KW - Models, Animal
KW - Myocardial Contraction
KW - Positron-Emission Tomography
KW - Pulmonary Artery/physiopathology
KW - Rats
KW - Rats, Wistar
KW - Time Factors
KW - Vena Cava, Inferior/physiopathology
KW - Vena Cava, Superior/physiopathology
KW - Ventricular Dysfunction, Left/diagnosis
KW - Ventricular Function, Left
KW - Ventricular Pressure
KW - Ventricular Remodeling
U2 - 10.1152/ajpheart.00218.2013
DO - 10.1152/ajpheart.00218.2013
M3 - SCORING: Journal article
C2 - 23771692
VL - 305
SP - 533
EP - 541
JO - AM J PHYSIOL-HEART C
JF - AM J PHYSIOL-HEART C
SN - 0363-6135
IS - 4
ER -