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Presence of the coxsackievirus and adenovirus receptor (CAR) in human neoplasms: a multitumour array analysis

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Presence of the coxsackievirus and adenovirus receptor (CAR) in human neoplasms: a multitumour array analysis. / Reeh, M; Bockhorn, M; Görgens, D; Vieth, M; Hoffmann, T; Simon, R; Izbicki, J R; Sauter, G; Schumacher, U; Anders, M.

In: BRIT J CANCER, Vol. 109, No. 7, 01.10.2013, p. 1848-58.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Reeh, M, Bockhorn, M, Görgens, D, Vieth, M, Hoffmann, T, Simon, R, Izbicki, JR, Sauter, G, Schumacher, U & Anders, M 2013, 'Presence of the coxsackievirus and adenovirus receptor (CAR) in human neoplasms: a multitumour array analysis', BRIT J CANCER, vol. 109, no. 7, pp. 1848-58. https://doi.org/10.1038/bjc.2013.509

APA

Reeh, M., Bockhorn, M., Görgens, D., Vieth, M., Hoffmann, T., Simon, R., Izbicki, J. R., Sauter, G., Schumacher, U., & Anders, M. (2013). Presence of the coxsackievirus and adenovirus receptor (CAR) in human neoplasms: a multitumour array analysis. BRIT J CANCER, 109(7), 1848-58. https://doi.org/10.1038/bjc.2013.509

Vancouver

Reeh M, Bockhorn M, Görgens D, Vieth M, Hoffmann T, Simon R et al. Presence of the coxsackievirus and adenovirus receptor (CAR) in human neoplasms: a multitumour array analysis. BRIT J CANCER. 2013 Oct 1;109(7):1848-58. https://doi.org/10.1038/bjc.2013.509

Bibtex

@article{e834bf1d7c484103bfcd2b1a12836b51,
title = "Presence of the coxsackievirus and adenovirus receptor (CAR) in human neoplasms: a multitumour array analysis",
abstract = "BACKGROUND: The Coxsackie- and Adenovirus Receptor (CAR) has been assigned two crucial attributes in carcinomas: (a) involvement in the regulation of growth and dissemination and (b) binding for potentially therapeutic adenoviruses. However, data on CAR expression in cancer types are conflicting and several entities have not been analysed to date.METHODS: The expression of CAR was assessed by immunohistochemical staining of tissue microarrays (TMA) containing 3714 specimens derived from 100 malignancies and from 273 normal control tissues.RESULTS: The expression of CAR was detected in all normal organs, except in the brain. Expression levels, however, displayed a broad range from being barely detectable (for example, in the thymus) to high abundance expression (for example, in the liver and gastric mucosa). In malignancies, a high degree of variability was notable also, ranging from significantly elevated CAR expression (for example, in early stages of malignant transformation and several tumours of the female reproductive system) to decreased CAR expression (for example, in colon and prostate cancer types).CONCLUSION: Our results provide a comprehensive insight into CAR expression in neoplasms and indicate that CAR may offer a valuable target for adenovirus-based therapy in a subset of carcinomas. Furthermore, these data suggest that CAR may contribute to carcinogenesis in an entity-dependent manner.",
keywords = "Adenoviridae Infections, Cell Transformation, Neoplastic, Coxsackie and Adenovirus Receptor-Like Membrane Protein, Coxsackievirus Infections, Gene Expression Regulation, Neoplastic, Humans, Neoplasms, Protein Array Analysis",
author = "M Reeh and M Bockhorn and D G{\"o}rgens and M Vieth and T Hoffmann and R Simon and Izbicki, {J R} and G Sauter and U Schumacher and M Anders",
year = "2013",
month = oct,
day = "1",
doi = "10.1038/bjc.2013.509",
language = "English",
volume = "109",
pages = "1848--58",
journal = "BRIT J CANCER",
issn = "0007-0920",
publisher = "NATURE PUBLISHING GROUP",
number = "7",

}

RIS

TY - JOUR

T1 - Presence of the coxsackievirus and adenovirus receptor (CAR) in human neoplasms: a multitumour array analysis

AU - Reeh, M

AU - Bockhorn, M

AU - Görgens, D

AU - Vieth, M

AU - Hoffmann, T

AU - Simon, R

AU - Izbicki, J R

AU - Sauter, G

AU - Schumacher, U

AU - Anders, M

PY - 2013/10/1

Y1 - 2013/10/1

N2 - BACKGROUND: The Coxsackie- and Adenovirus Receptor (CAR) has been assigned two crucial attributes in carcinomas: (a) involvement in the regulation of growth and dissemination and (b) binding for potentially therapeutic adenoviruses. However, data on CAR expression in cancer types are conflicting and several entities have not been analysed to date.METHODS: The expression of CAR was assessed by immunohistochemical staining of tissue microarrays (TMA) containing 3714 specimens derived from 100 malignancies and from 273 normal control tissues.RESULTS: The expression of CAR was detected in all normal organs, except in the brain. Expression levels, however, displayed a broad range from being barely detectable (for example, in the thymus) to high abundance expression (for example, in the liver and gastric mucosa). In malignancies, a high degree of variability was notable also, ranging from significantly elevated CAR expression (for example, in early stages of malignant transformation and several tumours of the female reproductive system) to decreased CAR expression (for example, in colon and prostate cancer types).CONCLUSION: Our results provide a comprehensive insight into CAR expression in neoplasms and indicate that CAR may offer a valuable target for adenovirus-based therapy in a subset of carcinomas. Furthermore, these data suggest that CAR may contribute to carcinogenesis in an entity-dependent manner.

AB - BACKGROUND: The Coxsackie- and Adenovirus Receptor (CAR) has been assigned two crucial attributes in carcinomas: (a) involvement in the regulation of growth and dissemination and (b) binding for potentially therapeutic adenoviruses. However, data on CAR expression in cancer types are conflicting and several entities have not been analysed to date.METHODS: The expression of CAR was assessed by immunohistochemical staining of tissue microarrays (TMA) containing 3714 specimens derived from 100 malignancies and from 273 normal control tissues.RESULTS: The expression of CAR was detected in all normal organs, except in the brain. Expression levels, however, displayed a broad range from being barely detectable (for example, in the thymus) to high abundance expression (for example, in the liver and gastric mucosa). In malignancies, a high degree of variability was notable also, ranging from significantly elevated CAR expression (for example, in early stages of malignant transformation and several tumours of the female reproductive system) to decreased CAR expression (for example, in colon and prostate cancer types).CONCLUSION: Our results provide a comprehensive insight into CAR expression in neoplasms and indicate that CAR may offer a valuable target for adenovirus-based therapy in a subset of carcinomas. Furthermore, these data suggest that CAR may contribute to carcinogenesis in an entity-dependent manner.

KW - Adenoviridae Infections

KW - Cell Transformation, Neoplastic

KW - Coxsackie and Adenovirus Receptor-Like Membrane Protein

KW - Coxsackievirus Infections

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Neoplasms

KW - Protein Array Analysis

U2 - 10.1038/bjc.2013.509

DO - 10.1038/bjc.2013.509

M3 - SCORING: Journal article

C2 - 24022195

VL - 109

SP - 1848

EP - 1858

JO - BRIT J CANCER

JF - BRIT J CANCER

SN - 0007-0920

IS - 7

ER -