Presence of Merkel cells in sun-exposed and not sun-exposed skin: a quantitative study.
Standard
Presence of Merkel cells in sun-exposed and not sun-exposed skin: a quantitative study. / Moll, Ingrid; Bladt, U; Jung, E G.
In: ARCH DERMATOL RES, Vol. 282, No. 4, 4, 1990, p. 213-216.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Presence of Merkel cells in sun-exposed and not sun-exposed skin: a quantitative study.
AU - Moll, Ingrid
AU - Bladt, U
AU - Jung, E G
PY - 1990
Y1 - 1990
N2 - Merkel cells (MCs), the neuroendocrine cells of the skin cannot be identified with certainty using conventional light microscopic staining methods. Using immunoperoxidase microscopy with antibodies specific for cytokeratin 18, which has been established as a marker protein of MCs, we have evaluated the numbers of MCs per mm2 skin in normal and sun-damaged upper arm skin. The sun-exposed skin contained twice as many MCs as the not sun exposed skin. Further quantification of MC density at various body sites (trunk, leg) showed a rather variable but often unexpectedly high MC density. The possible role of MC in development of actinic elastosis is discussed.
AB - Merkel cells (MCs), the neuroendocrine cells of the skin cannot be identified with certainty using conventional light microscopic staining methods. Using immunoperoxidase microscopy with antibodies specific for cytokeratin 18, which has been established as a marker protein of MCs, we have evaluated the numbers of MCs per mm2 skin in normal and sun-damaged upper arm skin. The sun-exposed skin contained twice as many MCs as the not sun exposed skin. Further quantification of MC density at various body sites (trunk, leg) showed a rather variable but often unexpectedly high MC density. The possible role of MC in development of actinic elastosis is discussed.
M3 - SCORING: Zeitschriftenaufsatz
VL - 282
SP - 213
EP - 216
JO - ARCH DERMATOL RES
JF - ARCH DERMATOL RES
SN - 0340-3696
IS - 4
M1 - 4
ER -