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Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons

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Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons. / Liew, Stephanie M; Chowdhury, Enayet K; Ernst, Michael E; Gilmartin-Thomas, Julia; Reid, Christopher M; Tonkin, Andrew; Neumann, Johannes; McNeil, John J; Kaye, David M.

In: ESC HEART FAIL, Vol. 9, No. 6, 12.2022, p. 3973-3984.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Liew, SM, Chowdhury, EK, Ernst, ME, Gilmartin-Thomas, J, Reid, CM, Tonkin, A, Neumann, J, McNeil, JJ & Kaye, DM 2022, 'Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons', ESC HEART FAIL, vol. 9, no. 6, pp. 3973-3984. https://doi.org/10.1002/ehf2.14101

APA

Liew, S. M., Chowdhury, E. K., Ernst, M. E., Gilmartin-Thomas, J., Reid, C. M., Tonkin, A., Neumann, J., McNeil, J. J., & Kaye, D. M. (2022). Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons. ESC HEART FAIL, 9(6), 3973-3984. https://doi.org/10.1002/ehf2.14101

Vancouver

Liew SM, Chowdhury EK, Ernst ME, Gilmartin-Thomas J, Reid CM, Tonkin A et al. Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons. ESC HEART FAIL. 2022 Dec;9(6):3973-3984. https://doi.org/10.1002/ehf2.14101

Bibtex

@article{2ea4c93962634c8ab3a1edb317f8f628,
title = "Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons",
abstract = "AIMS: Prescribed opioids are commonly used in the older community-dwelling population for the treatment of chronic pain. Although the harmful effects of opioid abuse and overdose are well understood, little is known about the long-term cardiovascular (CV) effects of prescribed opioids. The aim of this study was to investigate the CV effects associated with prescribed opioid use.METHODS AND RESULTS: A post hoc analysis of participants in the Aspirin in Reducing Events in the Elderly (ASPREE) trial was conducted. Participants in the ASPREE trial included community-dwelling older adults without a prior history of CV disease (CVD). Prescribed opioid use was defined as opioid use at baseline and/or at the first annual visit (AV1). Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals (95% CI) for associations between opioid use and CVD events following AV1. Of the 17 701 participants included (mean age 75.2 years, 58.2% female), 813 took opioids either at baseline or at AV1. Over a median follow-up period of 3.58 years (IQR 2.50-4.62), CVD events, most notably heart failure hospitalization, occurred in 7% (n = 57) amongst opioid users and 4% (n = 680) amongst non-opioid users. After adjustment for multiple covariates, opiate use was associated with a 1.67-fold (CI 1.26-2.23, P < 0.001) increase in the hazard ratio for CVD events.CONCLUSIONS: These findings identify opioid use as a non-traditional risk factor for CVD events in community-dwelling older adults.",
keywords = "Humans, Female, Aged, Aged, 80 and over, Male, Independent Living, Opioid-Related Disorders/epidemiology, Analgesics, Opioid/adverse effects, Drug Overdose/drug therapy, Cardiovascular Diseases/epidemiology",
author = "Liew, {Stephanie M} and Chowdhury, {Enayet K} and Ernst, {Michael E} and Julia Gilmartin-Thomas and Reid, {Christopher M} and Andrew Tonkin and Johannes Neumann and McNeil, {John J} and Kaye, {David M}",
note = "{\textcopyright} 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.",
year = "2022",
month = dec,
doi = "10.1002/ehf2.14101",
language = "English",
volume = "9",
pages = "3973--3984",
journal = "ESC HEART FAIL",
issn = "2055-5822",
publisher = "The Heart Failure Association of the European Society of Cardiology",
number = "6",

}

RIS

TY - JOUR

T1 - Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons

AU - Liew, Stephanie M

AU - Chowdhury, Enayet K

AU - Ernst, Michael E

AU - Gilmartin-Thomas, Julia

AU - Reid, Christopher M

AU - Tonkin, Andrew

AU - Neumann, Johannes

AU - McNeil, John J

AU - Kaye, David M

N1 - © 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

PY - 2022/12

Y1 - 2022/12

N2 - AIMS: Prescribed opioids are commonly used in the older community-dwelling population for the treatment of chronic pain. Although the harmful effects of opioid abuse and overdose are well understood, little is known about the long-term cardiovascular (CV) effects of prescribed opioids. The aim of this study was to investigate the CV effects associated with prescribed opioid use.METHODS AND RESULTS: A post hoc analysis of participants in the Aspirin in Reducing Events in the Elderly (ASPREE) trial was conducted. Participants in the ASPREE trial included community-dwelling older adults without a prior history of CV disease (CVD). Prescribed opioid use was defined as opioid use at baseline and/or at the first annual visit (AV1). Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals (95% CI) for associations between opioid use and CVD events following AV1. Of the 17 701 participants included (mean age 75.2 years, 58.2% female), 813 took opioids either at baseline or at AV1. Over a median follow-up period of 3.58 years (IQR 2.50-4.62), CVD events, most notably heart failure hospitalization, occurred in 7% (n = 57) amongst opioid users and 4% (n = 680) amongst non-opioid users. After adjustment for multiple covariates, opiate use was associated with a 1.67-fold (CI 1.26-2.23, P < 0.001) increase in the hazard ratio for CVD events.CONCLUSIONS: These findings identify opioid use as a non-traditional risk factor for CVD events in community-dwelling older adults.

AB - AIMS: Prescribed opioids are commonly used in the older community-dwelling population for the treatment of chronic pain. Although the harmful effects of opioid abuse and overdose are well understood, little is known about the long-term cardiovascular (CV) effects of prescribed opioids. The aim of this study was to investigate the CV effects associated with prescribed opioid use.METHODS AND RESULTS: A post hoc analysis of participants in the Aspirin in Reducing Events in the Elderly (ASPREE) trial was conducted. Participants in the ASPREE trial included community-dwelling older adults without a prior history of CV disease (CVD). Prescribed opioid use was defined as opioid use at baseline and/or at the first annual visit (AV1). Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals (95% CI) for associations between opioid use and CVD events following AV1. Of the 17 701 participants included (mean age 75.2 years, 58.2% female), 813 took opioids either at baseline or at AV1. Over a median follow-up period of 3.58 years (IQR 2.50-4.62), CVD events, most notably heart failure hospitalization, occurred in 7% (n = 57) amongst opioid users and 4% (n = 680) amongst non-opioid users. After adjustment for multiple covariates, opiate use was associated with a 1.67-fold (CI 1.26-2.23, P < 0.001) increase in the hazard ratio for CVD events.CONCLUSIONS: These findings identify opioid use as a non-traditional risk factor for CVD events in community-dwelling older adults.

KW - Humans

KW - Female

KW - Aged

KW - Aged, 80 and over

KW - Male

KW - Independent Living

KW - Opioid-Related Disorders/epidemiology

KW - Analgesics, Opioid/adverse effects

KW - Drug Overdose/drug therapy

KW - Cardiovascular Diseases/epidemiology

U2 - 10.1002/ehf2.14101

DO - 10.1002/ehf2.14101

M3 - SCORING: Journal article

C2 - 35985663

VL - 9

SP - 3973

EP - 3984

JO - ESC HEART FAIL

JF - ESC HEART FAIL

SN - 2055-5822

IS - 6

ER -