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Preprostatic lymph nodes in prostate cancer hot or not?

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Preprostatic lymph nodes in prostate cancer hot or not? Impact on oncological outcome after radical prostatectomy. / Korten, Michael; Pose, Randi M; Graefen, Markus; Tilki, Derya; Michl, Uwe; Knipper, Sophie; Beyer, Burkhard.

In: WORLD J UROL, Vol. 40, No. 9, 09.2022, p. 2231-2237.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Korten, M, Pose, RM, Graefen, M, Tilki, D, Michl, U, Knipper, S & Beyer, B 2022, 'Preprostatic lymph nodes in prostate cancer hot or not? Impact on oncological outcome after radical prostatectomy', WORLD J UROL, vol. 40, no. 9, pp. 2231-2237. https://doi.org/10.1007/s00345-022-04103-2

APA

Korten, M., Pose, R. M., Graefen, M., Tilki, D., Michl, U., Knipper, S., & Beyer, B. (2022). Preprostatic lymph nodes in prostate cancer hot or not? Impact on oncological outcome after radical prostatectomy. WORLD J UROL, 40(9), 2231-2237. https://doi.org/10.1007/s00345-022-04103-2

Vancouver

Korten M, Pose RM, Graefen M, Tilki D, Michl U, Knipper S et al. Preprostatic lymph nodes in prostate cancer hot or not? Impact on oncological outcome after radical prostatectomy. WORLD J UROL. 2022 Sep;40(9):2231-2237. https://doi.org/10.1007/s00345-022-04103-2

Bibtex

@article{107a301e97994aa2aec66b98202177fc,
title = "Preprostatic lymph nodes in prostate cancer hot or not?: Impact on oncological outcome after radical prostatectomy",
abstract = "OBJECTIVE: To assess the impact of preprostatic lymph node invasion on prostate cancer patients' outcome after radical prostatectomy. It is known that invasion of pelvic lymph nodes is associated with worse oncological outcome, but little is known about invasion of preprostatic lymph nodes. We hypothesized that positive preprostatic lymph nodes may not be as harmful as positive pelvic lymph nodes.MATERIALS AND METHODS: A total of 11,107 consecutive patients treated for prostate cancer with radical prostatectomy between 2013 and 2017 were evaluated. 1575 (14.2%) had some type of lymph node invasion, 53 (0.5%) had only one positive preprostatic lymph node and 705 (6.3%) had only one positive pelvic lymph node.RESULTS: Median follow-up was 37.7 months (interquartile range: 24.6-58.7 months). Baseline characteristics of the overall cohort were not statistically significant between the preprostatic vs. pelvic lymph node invasion groups, except for robot-assisted operation (64.2 vs. 32.3%, p < 0.001) and count of removed lymph nodes (16 vs. 19, p < 0.001). There was no statistically significant difference in 3-years biochemical recurrence rate (56.2 vs. 65.8%, p = 0.5), 3-years metastases free survival rate (87.4 vs. 95.5%, p = 0.5) and overall cancer-specific mortality (1.9 vs 1.0%) between the two groups.CONCLUSIONS: Preprostatic lymph node invasion seems to have a similar harmful effect as pelvic lymph node invasion and thus, if detected, may alter treatment and follow-up strategy. Therefore, it is important to perform a histological analysis when removing the preprostatic tissue.",
keywords = "Humans, Lymph Node Excision, Lymph Nodes/pathology, Male, Pelvis, Prostatectomy, Prostatic Neoplasms/pathology",
author = "Michael Korten and Pose, {Randi M} and Markus Graefen and Derya Tilki and Uwe Michl and Sophie Knipper and Burkhard Beyer",
note = "{\textcopyright} 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
year = "2022",
month = sep,
doi = "10.1007/s00345-022-04103-2",
language = "English",
volume = "40",
pages = "2231--2237",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Preprostatic lymph nodes in prostate cancer hot or not?

T2 - Impact on oncological outcome after radical prostatectomy

AU - Korten, Michael

AU - Pose, Randi M

AU - Graefen, Markus

AU - Tilki, Derya

AU - Michl, Uwe

AU - Knipper, Sophie

AU - Beyer, Burkhard

N1 - © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2022/9

Y1 - 2022/9

N2 - OBJECTIVE: To assess the impact of preprostatic lymph node invasion on prostate cancer patients' outcome after radical prostatectomy. It is known that invasion of pelvic lymph nodes is associated with worse oncological outcome, but little is known about invasion of preprostatic lymph nodes. We hypothesized that positive preprostatic lymph nodes may not be as harmful as positive pelvic lymph nodes.MATERIALS AND METHODS: A total of 11,107 consecutive patients treated for prostate cancer with radical prostatectomy between 2013 and 2017 were evaluated. 1575 (14.2%) had some type of lymph node invasion, 53 (0.5%) had only one positive preprostatic lymph node and 705 (6.3%) had only one positive pelvic lymph node.RESULTS: Median follow-up was 37.7 months (interquartile range: 24.6-58.7 months). Baseline characteristics of the overall cohort were not statistically significant between the preprostatic vs. pelvic lymph node invasion groups, except for robot-assisted operation (64.2 vs. 32.3%, p < 0.001) and count of removed lymph nodes (16 vs. 19, p < 0.001). There was no statistically significant difference in 3-years biochemical recurrence rate (56.2 vs. 65.8%, p = 0.5), 3-years metastases free survival rate (87.4 vs. 95.5%, p = 0.5) and overall cancer-specific mortality (1.9 vs 1.0%) between the two groups.CONCLUSIONS: Preprostatic lymph node invasion seems to have a similar harmful effect as pelvic lymph node invasion and thus, if detected, may alter treatment and follow-up strategy. Therefore, it is important to perform a histological analysis when removing the preprostatic tissue.

AB - OBJECTIVE: To assess the impact of preprostatic lymph node invasion on prostate cancer patients' outcome after radical prostatectomy. It is known that invasion of pelvic lymph nodes is associated with worse oncological outcome, but little is known about invasion of preprostatic lymph nodes. We hypothesized that positive preprostatic lymph nodes may not be as harmful as positive pelvic lymph nodes.MATERIALS AND METHODS: A total of 11,107 consecutive patients treated for prostate cancer with radical prostatectomy between 2013 and 2017 were evaluated. 1575 (14.2%) had some type of lymph node invasion, 53 (0.5%) had only one positive preprostatic lymph node and 705 (6.3%) had only one positive pelvic lymph node.RESULTS: Median follow-up was 37.7 months (interquartile range: 24.6-58.7 months). Baseline characteristics of the overall cohort were not statistically significant between the preprostatic vs. pelvic lymph node invasion groups, except for robot-assisted operation (64.2 vs. 32.3%, p < 0.001) and count of removed lymph nodes (16 vs. 19, p < 0.001). There was no statistically significant difference in 3-years biochemical recurrence rate (56.2 vs. 65.8%, p = 0.5), 3-years metastases free survival rate (87.4 vs. 95.5%, p = 0.5) and overall cancer-specific mortality (1.9 vs 1.0%) between the two groups.CONCLUSIONS: Preprostatic lymph node invasion seems to have a similar harmful effect as pelvic lymph node invasion and thus, if detected, may alter treatment and follow-up strategy. Therefore, it is important to perform a histological analysis when removing the preprostatic tissue.

KW - Humans

KW - Lymph Node Excision

KW - Lymph Nodes/pathology

KW - Male

KW - Pelvis

KW - Prostatectomy

KW - Prostatic Neoplasms/pathology

U2 - 10.1007/s00345-022-04103-2

DO - 10.1007/s00345-022-04103-2

M3 - SCORING: Journal article

C2 - 35876871

VL - 40

SP - 2231

EP - 2237

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 9

ER -