Preoperative plasma level of endoglin as a predictor for disease outcomes after radical cystectomy for nonmetastatic urothelial carcinoma of the bladder
Standard
Preoperative plasma level of endoglin as a predictor for disease outcomes after radical cystectomy for nonmetastatic urothelial carcinoma of the bladder. / Laukhtina, Ekaterina; Schuettfort, Victor M; D'Andrea, David; Pradere, Benjamin; Mori, Keiichiro; Quhal, Fahad; Sari Motlagh, Reza; Mostafaei, Hadi; Katayama, Satoshi; Grossmann, Nico С; Rajwa, Pawel; Zeinler, Flora; Abufaraj, Mohammad; Moschini, Marco; Zimmermann, Kristin; Karakiewicz, Pierre I; Fajkovic, Harun; Scherr, Douglas; Compérat, Eva; Nyirady, Peter; Rink, Michael; Enikeev, Dmitry; Shariat, Shahrokh F.
In: MOL CARCINOGEN, Vol. 61, No. 1, 01.2022, p. 5-18.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Preoperative plasma level of endoglin as a predictor for disease outcomes after radical cystectomy for nonmetastatic urothelial carcinoma of the bladder
AU - Laukhtina, Ekaterina
AU - Schuettfort, Victor M
AU - D'Andrea, David
AU - Pradere, Benjamin
AU - Mori, Keiichiro
AU - Quhal, Fahad
AU - Sari Motlagh, Reza
AU - Mostafaei, Hadi
AU - Katayama, Satoshi
AU - Grossmann, Nico С
AU - Rajwa, Pawel
AU - Zeinler, Flora
AU - Abufaraj, Mohammad
AU - Moschini, Marco
AU - Zimmermann, Kristin
AU - Karakiewicz, Pierre I
AU - Fajkovic, Harun
AU - Scherr, Douglas
AU - Compérat, Eva
AU - Nyirady, Peter
AU - Rink, Michael
AU - Enikeev, Dmitry
AU - Shariat, Shahrokh F
N1 - © 2021 The Authors. Molecular Carcinogenesis published by Wiley Periodicals LLC.
PY - 2022/1
Y1 - 2022/1
N2 - Elevated preoperative plasma level of endoglin has been associated with worse oncologic outcomes in various malignancies. The present large-scale study aimed to determine the predictive and prognostic values of preoperative endoglin with regard to clinicopathologic and survival outcomes in patients treated with radical cystectomy (RC) for nonmetastatic urothelial carcinoma of the bladder (UCB). We prospectively collected preoperative blood samples from 1036 consecutive patients treated with RC for UCB. Logistic and Cox regression analyses were undertaken to assess the correlation of endoglin levels with pathologic and survival outcomes, respectively. The AUC and C-index were used to assess the discrimination. Patients with adverse pathologic features had significantly higher median preoperative endoglin plasma levels than their counterparts. Higher preoperative endoglin level was independently associated with an increased risk for lymph node metastasis, ≥pT3 disease, and nonorgan confined disease (NOCD; all p < 0.001). Plasma endoglin level was also independently associated with cancer-specific and overall survival in both pre- and postoperative models (all p < 0.05), as well as with recurrence-free survival (RFS) in the preoperative model (p < 0.001). The addition of endoglin to the preoperative standard model improved its discrimination for prediction of lymph node metastasis, ≥pT3 disease, NOCD, and RFS (differential increases in C-indices: 10%, 5%, 5.8%, and 4%, respectively). Preoperative plasma endoglin is associated with features of biologically and clinically aggressive UCB as well as survival outcomes. Therefore, it seems to hold the potential of identifying UCB patients who may benefit from intensified therapy in addition to RC such as extended lymphadenectomy or/and preoperative systemic therapy.
AB - Elevated preoperative plasma level of endoglin has been associated with worse oncologic outcomes in various malignancies. The present large-scale study aimed to determine the predictive and prognostic values of preoperative endoglin with regard to clinicopathologic and survival outcomes in patients treated with radical cystectomy (RC) for nonmetastatic urothelial carcinoma of the bladder (UCB). We prospectively collected preoperative blood samples from 1036 consecutive patients treated with RC for UCB. Logistic and Cox regression analyses were undertaken to assess the correlation of endoglin levels with pathologic and survival outcomes, respectively. The AUC and C-index were used to assess the discrimination. Patients with adverse pathologic features had significantly higher median preoperative endoglin plasma levels than their counterparts. Higher preoperative endoglin level was independently associated with an increased risk for lymph node metastasis, ≥pT3 disease, and nonorgan confined disease (NOCD; all p < 0.001). Plasma endoglin level was also independently associated with cancer-specific and overall survival in both pre- and postoperative models (all p < 0.05), as well as with recurrence-free survival (RFS) in the preoperative model (p < 0.001). The addition of endoglin to the preoperative standard model improved its discrimination for prediction of lymph node metastasis, ≥pT3 disease, NOCD, and RFS (differential increases in C-indices: 10%, 5%, 5.8%, and 4%, respectively). Preoperative plasma endoglin is associated with features of biologically and clinically aggressive UCB as well as survival outcomes. Therefore, it seems to hold the potential of identifying UCB patients who may benefit from intensified therapy in addition to RC such as extended lymphadenectomy or/and preoperative systemic therapy.
KW - Aged
KW - Biomarkers, Tumor/blood
KW - Carcinoma, Transitional Cell/blood
KW - Cystectomy
KW - Endoglin/blood
KW - Female
KW - Gene Expression Regulation, Neoplastic
KW - Humans
KW - Lymph Node Excision
KW - Male
KW - Middle Aged
KW - Neoplasm Staging
KW - Preoperative Period
KW - Prognosis
KW - Prospective Studies
KW - Survival Analysis
KW - Treatment Outcome
KW - Urinary Bladder Neoplasms/blood
U2 - 10.1002/mc.23355
DO - 10.1002/mc.23355
M3 - SCORING: Journal article
C2 - 34587660
VL - 61
SP - 5
EP - 18
JO - MOL CARCINOGEN
JF - MOL CARCINOGEN
SN - 0899-1987
IS - 1
ER -
