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Preoperative evaluation of pelvine lymph node metastasis in high risk prostate cancer with intravoxel incoherent motion (IVIM) MRI

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Preoperative evaluation of pelvine lymph node metastasis in high risk prostate cancer with intravoxel incoherent motion (IVIM) MRI. / Sauer, Markus; Klene, Christiane; Kaul, Michael; Quitzke, Azien; Avanesov, Maxim; Behzadi, Cyrus; Budäus, Lars; Beyersdorff, Dirk; Adam, Gerhard; Regier, Marc.

In: EUR J RADIOL, Vol. 107, 10.2018, p. 1-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sauer, M, Klene, C, Kaul, M, Quitzke, A, Avanesov, M, Behzadi, C, Budäus, L, Beyersdorff, D, Adam, G & Regier, M 2018, 'Preoperative evaluation of pelvine lymph node metastasis in high risk prostate cancer with intravoxel incoherent motion (IVIM) MRI', EUR J RADIOL, vol. 107, pp. 1-6. https://doi.org/10.1016/j.ejrad.2018.07.029

APA

Sauer, M., Klene, C., Kaul, M., Quitzke, A., Avanesov, M., Behzadi, C., Budäus, L., Beyersdorff, D., Adam, G., & Regier, M. (2018). Preoperative evaluation of pelvine lymph node metastasis in high risk prostate cancer with intravoxel incoherent motion (IVIM) MRI. EUR J RADIOL, 107, 1-6. https://doi.org/10.1016/j.ejrad.2018.07.029

Vancouver

Sauer M, Klene C, Kaul M, Quitzke A, Avanesov M, Behzadi C et al. Preoperative evaluation of pelvine lymph node metastasis in high risk prostate cancer with intravoxel incoherent motion (IVIM) MRI. EUR J RADIOL. 2018 Oct;107:1-6. https://doi.org/10.1016/j.ejrad.2018.07.029

Bibtex

@article{6db2740d030947d7a9c9181d5e82b771,
title = "Preoperative evaluation of pelvine lymph node metastasis in high risk prostate cancer with intravoxel incoherent motion (IVIM) MRI",
abstract = "OBJECTIVES: To evaluate benign and malignant pelvine lymph nodes in prostate cancer patients with biexponential intravoxel incoherent motion (IVIM) MRI of the prostate prior to radical prostatectomy.METHODS: The ethics committee approved this retrospective study with waiver of informed consent. From February 2012 to November 2013 43 patients with histopathologically proven prostatic cancer were included. All patients were examined applying a standardized MRI protocol including IVIM diffusion weighted imaging with multiple b-values ranging from 0 to 950 s/mm². MR imaging was performed one day prior to radical prostatectomy. Thereafter, extended lymph node resection was performed. For each MRI all visible lymph nodes were registered and calculated as individual regions of interest. These findings were correlated with postoperative pathology. The apparent diffusion coefficient ADC, the diffusion coefficient D and the perfusion fraction f were calculated from IVIM DWI using a biexponential fit.RESULTS: A total of 120 lymph nodes were detected on MRI. 95 of these were determined as benign and 25 as malignant. The average ADC was significantly lower in malignant compared to benign lymph nodes (0.88 × 10-³ vs 1.67 × 10-³ mm²/s, p < 0.001). Likewise, the average diffusion coefficient D was significantly lower in lymph node metastasis (0.54 × 10-³ vs 1.10 × 10-³ mm²/s, p < .001). The signal rate due to perfusion was significantly higher in malignant compared to benign nodes (33.4% vs. 27.1%, p = 0.02).CONCLUSIONS: Applying biexponential IVIM MRI demonstrates significant differences in diffusion parameters ADC and D, as well as in the perfusion fraction f for benign and malignant lymph nodes. Therefore, IVIM might help to further improve the preoperative assessment of lymph nodes in MRI.",
keywords = "Adult, Aged, Biopsy, Diffusion Magnetic Resonance Imaging, Humans, Image Processing, Computer-Assisted, Lymph Nodes, Lymphatic Metastasis, Magnetic Resonance Imaging, Male, Middle Aged, Motion, Preoperative Care, Prostate, Prostatic Neoplasms, Retrospective Studies, Risk, Journal Article",
author = "Markus Sauer and Christiane Klene and Michael Kaul and Azien Quitzke and Maxim Avanesov and Cyrus Behzadi and Lars Bud{\"a}us and Dirk Beyersdorff and Gerhard Adam and Marc Regier",
note = "Copyright {\textcopyright} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
month = oct,
doi = "10.1016/j.ejrad.2018.07.029",
language = "English",
volume = "107",
pages = "1--6",
journal = "EUR J RADIOL",
issn = "0720-048X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Preoperative evaluation of pelvine lymph node metastasis in high risk prostate cancer with intravoxel incoherent motion (IVIM) MRI

AU - Sauer, Markus

AU - Klene, Christiane

AU - Kaul, Michael

AU - Quitzke, Azien

AU - Avanesov, Maxim

AU - Behzadi, Cyrus

AU - Budäus, Lars

AU - Beyersdorff, Dirk

AU - Adam, Gerhard

AU - Regier, Marc

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018/10

Y1 - 2018/10

N2 - OBJECTIVES: To evaluate benign and malignant pelvine lymph nodes in prostate cancer patients with biexponential intravoxel incoherent motion (IVIM) MRI of the prostate prior to radical prostatectomy.METHODS: The ethics committee approved this retrospective study with waiver of informed consent. From February 2012 to November 2013 43 patients with histopathologically proven prostatic cancer were included. All patients were examined applying a standardized MRI protocol including IVIM diffusion weighted imaging with multiple b-values ranging from 0 to 950 s/mm². MR imaging was performed one day prior to radical prostatectomy. Thereafter, extended lymph node resection was performed. For each MRI all visible lymph nodes were registered and calculated as individual regions of interest. These findings were correlated with postoperative pathology. The apparent diffusion coefficient ADC, the diffusion coefficient D and the perfusion fraction f were calculated from IVIM DWI using a biexponential fit.RESULTS: A total of 120 lymph nodes were detected on MRI. 95 of these were determined as benign and 25 as malignant. The average ADC was significantly lower in malignant compared to benign lymph nodes (0.88 × 10-³ vs 1.67 × 10-³ mm²/s, p < 0.001). Likewise, the average diffusion coefficient D was significantly lower in lymph node metastasis (0.54 × 10-³ vs 1.10 × 10-³ mm²/s, p < .001). The signal rate due to perfusion was significantly higher in malignant compared to benign nodes (33.4% vs. 27.1%, p = 0.02).CONCLUSIONS: Applying biexponential IVIM MRI demonstrates significant differences in diffusion parameters ADC and D, as well as in the perfusion fraction f for benign and malignant lymph nodes. Therefore, IVIM might help to further improve the preoperative assessment of lymph nodes in MRI.

AB - OBJECTIVES: To evaluate benign and malignant pelvine lymph nodes in prostate cancer patients with biexponential intravoxel incoherent motion (IVIM) MRI of the prostate prior to radical prostatectomy.METHODS: The ethics committee approved this retrospective study with waiver of informed consent. From February 2012 to November 2013 43 patients with histopathologically proven prostatic cancer were included. All patients were examined applying a standardized MRI protocol including IVIM diffusion weighted imaging with multiple b-values ranging from 0 to 950 s/mm². MR imaging was performed one day prior to radical prostatectomy. Thereafter, extended lymph node resection was performed. For each MRI all visible lymph nodes were registered and calculated as individual regions of interest. These findings were correlated with postoperative pathology. The apparent diffusion coefficient ADC, the diffusion coefficient D and the perfusion fraction f were calculated from IVIM DWI using a biexponential fit.RESULTS: A total of 120 lymph nodes were detected on MRI. 95 of these were determined as benign and 25 as malignant. The average ADC was significantly lower in malignant compared to benign lymph nodes (0.88 × 10-³ vs 1.67 × 10-³ mm²/s, p < 0.001). Likewise, the average diffusion coefficient D was significantly lower in lymph node metastasis (0.54 × 10-³ vs 1.10 × 10-³ mm²/s, p < .001). The signal rate due to perfusion was significantly higher in malignant compared to benign nodes (33.4% vs. 27.1%, p = 0.02).CONCLUSIONS: Applying biexponential IVIM MRI demonstrates significant differences in diffusion parameters ADC and D, as well as in the perfusion fraction f for benign and malignant lymph nodes. Therefore, IVIM might help to further improve the preoperative assessment of lymph nodes in MRI.

KW - Adult

KW - Aged

KW - Biopsy

KW - Diffusion Magnetic Resonance Imaging

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Lymph Nodes

KW - Lymphatic Metastasis

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Motion

KW - Preoperative Care

KW - Prostate

KW - Prostatic Neoplasms

KW - Retrospective Studies

KW - Risk

KW - Journal Article

U2 - 10.1016/j.ejrad.2018.07.029

DO - 10.1016/j.ejrad.2018.07.029

M3 - SCORING: Journal article

C2 - 30292252

VL - 107

SP - 1

EP - 6

JO - EUR J RADIOL

JF - EUR J RADIOL

SN - 0720-048X

ER -