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Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT

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Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT. / Li, Jun; Kuehl, Hilmar; Grabellus, Florian; Müller, Stephan P; Radunz, Sonia; Antoch, Gerald; Nadalin, Silvio; Broelsch, Christoph E; Gerken, Guido; Paul, Andreas; Kaiser, Gernot M.

In: J SURG ONCOL, Vol. 98, No. 6, 01.11.2008, p. 438-43.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Li, J, Kuehl, H, Grabellus, F, Müller, SP, Radunz, S, Antoch, G, Nadalin, S, Broelsch, CE, Gerken, G, Paul, A & Kaiser, GM 2008, 'Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT', J SURG ONCOL, vol. 98, no. 6, pp. 438-43. https://doi.org/10.1002/jso.21136

APA

Li, J., Kuehl, H., Grabellus, F., Müller, S. P., Radunz, S., Antoch, G., Nadalin, S., Broelsch, C. E., Gerken, G., Paul, A., & Kaiser, G. M. (2008). Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT. J SURG ONCOL, 98(6), 438-43. https://doi.org/10.1002/jso.21136

Vancouver

Li J, Kuehl H, Grabellus F, Müller SP, Radunz S, Antoch G et al. Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT. J SURG ONCOL. 2008 Nov 1;98(6):438-43. https://doi.org/10.1002/jso.21136

Bibtex

@article{16edfaf29eb94792abaddfbd3a1dc4b3,
title = "Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT",
abstract = "BACKGROUND: The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma.MATERIALS AND METHODS: From June 2004 to December 2007, patients evaluated for surgical treatment of hilar cholangiocarcinoma were entered into a prospective database. Dual modality (18)F-FDG PET/CT was performed before surgery. The report was reviewed with comparison to the operative and pathological results in each case for tumour-node-metastasis staging.RESULTS: Seventeen patients (6 women, 11 men) of a median age of 62 years were included in the study. Radical tumour resection was performed on seven patients. Ten patients underwent surgical exploration. The sensitivity of PET/CT in detecting primary tumour was found to be 58.8% (25% in T2 tumour, 70% in T3 tumour, 66.7% in T4 tumour). The sensitivity/specificity of PET/CT in detecting lymph node metastasis and distant metastasis were 41.7%/80% and 55.6%/87.5%, respectively. Positive (18)F-FDG uptake in the bile duct was found to be associated with surgical non-resectability (P = 0.05).CONCLUSION: Dual-modality PET/CT imaging was found to have a high specificity in detection of lymph node and distant metastasis in hilar cholangiocarcinoma, with a limited value in correct judgement of surgical resectability for tumours in stadium UICC I-III.",
keywords = "Bile Duct Neoplasms, Bile Ducts, Intrahepatic, Cholangiocarcinoma, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Staging, Positron-Emission Tomography, Preoperative Care, Prospective Studies, Radiopharmaceuticals, Sensitivity and Specificity, Tomography, X-Ray Computed, Journal Article",
author = "Jun Li and Hilmar Kuehl and Florian Grabellus and M{\"u}ller, {Stephan P} and Sonia Radunz and Gerald Antoch and Silvio Nadalin and Broelsch, {Christoph E} and Guido Gerken and Andreas Paul and Kaiser, {Gernot M}",
note = "(c) 2008 Wiley-Liss, Inc.",
year = "2008",
month = nov,
day = "1",
doi = "10.1002/jso.21136",
language = "English",
volume = "98",
pages = "438--43",
journal = "J SURG ONCOL",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT

AU - Li, Jun

AU - Kuehl, Hilmar

AU - Grabellus, Florian

AU - Müller, Stephan P

AU - Radunz, Sonia

AU - Antoch, Gerald

AU - Nadalin, Silvio

AU - Broelsch, Christoph E

AU - Gerken, Guido

AU - Paul, Andreas

AU - Kaiser, Gernot M

N1 - (c) 2008 Wiley-Liss, Inc.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - BACKGROUND: The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma.MATERIALS AND METHODS: From June 2004 to December 2007, patients evaluated for surgical treatment of hilar cholangiocarcinoma were entered into a prospective database. Dual modality (18)F-FDG PET/CT was performed before surgery. The report was reviewed with comparison to the operative and pathological results in each case for tumour-node-metastasis staging.RESULTS: Seventeen patients (6 women, 11 men) of a median age of 62 years were included in the study. Radical tumour resection was performed on seven patients. Ten patients underwent surgical exploration. The sensitivity of PET/CT in detecting primary tumour was found to be 58.8% (25% in T2 tumour, 70% in T3 tumour, 66.7% in T4 tumour). The sensitivity/specificity of PET/CT in detecting lymph node metastasis and distant metastasis were 41.7%/80% and 55.6%/87.5%, respectively. Positive (18)F-FDG uptake in the bile duct was found to be associated with surgical non-resectability (P = 0.05).CONCLUSION: Dual-modality PET/CT imaging was found to have a high specificity in detection of lymph node and distant metastasis in hilar cholangiocarcinoma, with a limited value in correct judgement of surgical resectability for tumours in stadium UICC I-III.

AB - BACKGROUND: The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma.MATERIALS AND METHODS: From June 2004 to December 2007, patients evaluated for surgical treatment of hilar cholangiocarcinoma were entered into a prospective database. Dual modality (18)F-FDG PET/CT was performed before surgery. The report was reviewed with comparison to the operative and pathological results in each case for tumour-node-metastasis staging.RESULTS: Seventeen patients (6 women, 11 men) of a median age of 62 years were included in the study. Radical tumour resection was performed on seven patients. Ten patients underwent surgical exploration. The sensitivity of PET/CT in detecting primary tumour was found to be 58.8% (25% in T2 tumour, 70% in T3 tumour, 66.7% in T4 tumour). The sensitivity/specificity of PET/CT in detecting lymph node metastasis and distant metastasis were 41.7%/80% and 55.6%/87.5%, respectively. Positive (18)F-FDG uptake in the bile duct was found to be associated with surgical non-resectability (P = 0.05).CONCLUSION: Dual-modality PET/CT imaging was found to have a high specificity in detection of lymph node and distant metastasis in hilar cholangiocarcinoma, with a limited value in correct judgement of surgical resectability for tumours in stadium UICC I-III.

KW - Bile Duct Neoplasms

KW - Bile Ducts, Intrahepatic

KW - Cholangiocarcinoma

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm Metastasis

KW - Neoplasm Staging

KW - Positron-Emission Tomography

KW - Preoperative Care

KW - Prospective Studies

KW - Radiopharmaceuticals

KW - Sensitivity and Specificity

KW - Tomography, X-Ray Computed

KW - Journal Article

U2 - 10.1002/jso.21136

DO - 10.1002/jso.21136

M3 - SCORING: Journal article

C2 - 18767120

VL - 98

SP - 438

EP - 443

JO - J SURG ONCOL

JF - J SURG ONCOL

SN - 0022-4790

IS - 6

ER -