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Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition

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Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition. / Hartwig, Isabel R V; Sly, Peter D; Schmidt, Louis A; van Lieshout, Ryan J; Bienenstock, John; Holt, Patrick G; Arck, Petra C.

In: J ALLERGY CLIN IMMUN, Vol. 134, No. 1, 01.07.2014, p. 160-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hartwig, IRV, Sly, PD, Schmidt, LA, van Lieshout, RJ, Bienenstock, J, Holt, PG & Arck, PC 2014, 'Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition', J ALLERGY CLIN IMMUN, vol. 134, no. 1, pp. 160-9. https://doi.org/10.1016/j.jaci.2014.01.033

APA

Hartwig, I. R. V., Sly, P. D., Schmidt, L. A., van Lieshout, R. J., Bienenstock, J., Holt, P. G., & Arck, P. C. (2014). Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition. J ALLERGY CLIN IMMUN, 134(1), 160-9. https://doi.org/10.1016/j.jaci.2014.01.033

Vancouver

Hartwig IRV, Sly PD, Schmidt LA, van Lieshout RJ, Bienenstock J, Holt PG et al. Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition. J ALLERGY CLIN IMMUN. 2014 Jul 1;134(1):160-9. https://doi.org/10.1016/j.jaci.2014.01.033

Bibtex

@article{7b37e9b595a54f1093c64dc6652a7822,
title = "Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition",
abstract = "BACKGROUND: There is evidence to suggest an association between prenatal maternal stress and the development of asthma or other atopic diseases in offspring. Yet, insights on the lasting effect of multiple, common prenatal stressors are rare, and the effects of prenatal timing are poorly understood. Further, it remains elusive if prenatal life events modify the risk for atopic diseases in the context of a parental predisposition to atopy.OBJECTIVE: We tested whether women's experiences of common, adverse life events during the first or second half of pregnancy predicted the risk of developing atopic diseases in their children and whether a reported parental atopic disease moderated this association.METHODS: We calculated the odds of a child developing asthma, eczema, and/or allergic rhinitis at ages 6 or 14 years, depending on maternal prenatal exposure to negative life events in a sample of 1587 children from the Western Australian Pregnancy Cohort (Raine) Study by using multivariable logistic regression.RESULTS: We observed that the likelihood of asthma and eczema at age 14 years was significantly increased in children of mothers who had experienced adverse life events during the second half of gestation (1 life event: adjusted odds ratio for asthma, 2.08 [95% CI, 1.22-3.54]). A stronger increase in the odds to develop asthma upon prenatal life events was present in children of mothers without asthma compared with mothers with asthma.CONCLUSIONS: Maternal adverse life events during the second half of gestation are linked to an increased risk for the development of atopic disorders, asthma, and eczema, in the case of asthma, particularly in the absence of a maternal asthma.",
keywords = "Adolescent, Adult, Asthma, Australia, Child, Eczema, Female, Humans, Logistic Models, Longitudinal Studies, Male, Odds Ratio, Pregnancy, Prenatal Exposure Delayed Effects, Questionnaires, Risk, Risk Factors, Stress, Psychological",
author = "Hartwig, {Isabel R V} and Sly, {Peter D} and Schmidt, {Louis A} and {van Lieshout}, {Ryan J} and John Bienenstock and Holt, {Patrick G} and Arck, {Petra C}",
note = "Copyright {\textcopyright} 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.",
year = "2014",
month = jul,
day = "1",
doi = "10.1016/j.jaci.2014.01.033",
language = "English",
volume = "134",
pages = "160--9",
journal = "J ALLERGY CLIN IMMUN",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition

AU - Hartwig, Isabel R V

AU - Sly, Peter D

AU - Schmidt, Louis A

AU - van Lieshout, Ryan J

AU - Bienenstock, John

AU - Holt, Patrick G

AU - Arck, Petra C

N1 - Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

PY - 2014/7/1

Y1 - 2014/7/1

N2 - BACKGROUND: There is evidence to suggest an association between prenatal maternal stress and the development of asthma or other atopic diseases in offspring. Yet, insights on the lasting effect of multiple, common prenatal stressors are rare, and the effects of prenatal timing are poorly understood. Further, it remains elusive if prenatal life events modify the risk for atopic diseases in the context of a parental predisposition to atopy.OBJECTIVE: We tested whether women's experiences of common, adverse life events during the first or second half of pregnancy predicted the risk of developing atopic diseases in their children and whether a reported parental atopic disease moderated this association.METHODS: We calculated the odds of a child developing asthma, eczema, and/or allergic rhinitis at ages 6 or 14 years, depending on maternal prenatal exposure to negative life events in a sample of 1587 children from the Western Australian Pregnancy Cohort (Raine) Study by using multivariable logistic regression.RESULTS: We observed that the likelihood of asthma and eczema at age 14 years was significantly increased in children of mothers who had experienced adverse life events during the second half of gestation (1 life event: adjusted odds ratio for asthma, 2.08 [95% CI, 1.22-3.54]). A stronger increase in the odds to develop asthma upon prenatal life events was present in children of mothers without asthma compared with mothers with asthma.CONCLUSIONS: Maternal adverse life events during the second half of gestation are linked to an increased risk for the development of atopic disorders, asthma, and eczema, in the case of asthma, particularly in the absence of a maternal asthma.

AB - BACKGROUND: There is evidence to suggest an association between prenatal maternal stress and the development of asthma or other atopic diseases in offspring. Yet, insights on the lasting effect of multiple, common prenatal stressors are rare, and the effects of prenatal timing are poorly understood. Further, it remains elusive if prenatal life events modify the risk for atopic diseases in the context of a parental predisposition to atopy.OBJECTIVE: We tested whether women's experiences of common, adverse life events during the first or second half of pregnancy predicted the risk of developing atopic diseases in their children and whether a reported parental atopic disease moderated this association.METHODS: We calculated the odds of a child developing asthma, eczema, and/or allergic rhinitis at ages 6 or 14 years, depending on maternal prenatal exposure to negative life events in a sample of 1587 children from the Western Australian Pregnancy Cohort (Raine) Study by using multivariable logistic regression.RESULTS: We observed that the likelihood of asthma and eczema at age 14 years was significantly increased in children of mothers who had experienced adverse life events during the second half of gestation (1 life event: adjusted odds ratio for asthma, 2.08 [95% CI, 1.22-3.54]). A stronger increase in the odds to develop asthma upon prenatal life events was present in children of mothers without asthma compared with mothers with asthma.CONCLUSIONS: Maternal adverse life events during the second half of gestation are linked to an increased risk for the development of atopic disorders, asthma, and eczema, in the case of asthma, particularly in the absence of a maternal asthma.

KW - Adolescent

KW - Adult

KW - Asthma

KW - Australia

KW - Child

KW - Eczema

KW - Female

KW - Humans

KW - Logistic Models

KW - Longitudinal Studies

KW - Male

KW - Odds Ratio

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Questionnaires

KW - Risk

KW - Risk Factors

KW - Stress, Psychological

U2 - 10.1016/j.jaci.2014.01.033

DO - 10.1016/j.jaci.2014.01.033

M3 - SCORING: Journal article

C2 - 25117802

VL - 134

SP - 160

EP - 169

JO - J ALLERGY CLIN IMMUN

JF - J ALLERGY CLIN IMMUN

SN - 0091-6749

IS - 1

ER -