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Premotor-motor excitability is altered in dopa-responsive dystonia

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Premotor-motor excitability is altered in dopa-responsive dystonia. / Weissbach, Anne; Bäumer, Tobias; Brüggemann, Norbert; Tadic, Vera; Zittel, Simone; Cheng, Bastian; Thomalla, Götz; Klein, Christine; Münchau, Alexander.

In: MOVEMENT DISORD, Vol. 30, No. 12, 10.2015, p. 1705-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Weissbach, A, Bäumer, T, Brüggemann, N, Tadic, V, Zittel, S, Cheng, B, Thomalla, G, Klein, C & Münchau, A 2015, 'Premotor-motor excitability is altered in dopa-responsive dystonia', MOVEMENT DISORD, vol. 30, no. 12, pp. 1705-9. https://doi.org/10.1002/mds.26365

APA

Weissbach, A., Bäumer, T., Brüggemann, N., Tadic, V., Zittel, S., Cheng, B., Thomalla, G., Klein, C., & Münchau, A. (2015). Premotor-motor excitability is altered in dopa-responsive dystonia. MOVEMENT DISORD, 30(12), 1705-9. https://doi.org/10.1002/mds.26365

Vancouver

Weissbach A, Bäumer T, Brüggemann N, Tadic V, Zittel S, Cheng B et al. Premotor-motor excitability is altered in dopa-responsive dystonia. MOVEMENT DISORD. 2015 Oct;30(12):1705-9. https://doi.org/10.1002/mds.26365

Bibtex

@article{5a5167a595cb43839b733906abc79f9f,
title = "Premotor-motor excitability is altered in dopa-responsive dystonia",
abstract = "BACKGROUND: Dopa-responsive dystonia is clinically dominated by a combination of dystonia and parkinsonism, both known to be associated with abnormal activity in premotor-motor circuits.METHODS: To probe premotor-motor excitability, we used a transcranial magnetic stimulation dual pulse conditioning paradigm in 15 genetically confirmed dopa-responsive dystonia patients and 20 controls under different medication states. We also determined silent periods, short-latency afferent inhibition, interhemispheric inhibition, and short-interval intracortical inhibition and facilitation.RESULTS: In contrast to healthy controls, no motor cortex inhibition was seen after premotor conditioning regardless of the dopaminergic state in patients. The duration of the ipsilateral silent period was increased in the OFF state, and short-latency afferent inhibition was reduced in the ON compared with the OFF state.CONCLUSION: Premotor-motor circuits appear hyporesponsive in dopa-responsive dystonia. {\textcopyright} 2015 International Parkinson and Movement Disorder Society.",
author = "Anne Weissbach and Tobias B{\"a}umer and Norbert Br{\"u}ggemann and Vera Tadic and Simone Zittel and Bastian Cheng and G{\"o}tz Thomalla and Christine Klein and Alexander M{\"u}nchau",
note = "{\textcopyright} 2015 International Parkinson and Movement Disorder Society.",
year = "2015",
month = oct,
doi = "10.1002/mds.26365",
language = "English",
volume = "30",
pages = "1705--9",
journal = "MOVEMENT DISORD",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Premotor-motor excitability is altered in dopa-responsive dystonia

AU - Weissbach, Anne

AU - Bäumer, Tobias

AU - Brüggemann, Norbert

AU - Tadic, Vera

AU - Zittel, Simone

AU - Cheng, Bastian

AU - Thomalla, Götz

AU - Klein, Christine

AU - Münchau, Alexander

N1 - © 2015 International Parkinson and Movement Disorder Society.

PY - 2015/10

Y1 - 2015/10

N2 - BACKGROUND: Dopa-responsive dystonia is clinically dominated by a combination of dystonia and parkinsonism, both known to be associated with abnormal activity in premotor-motor circuits.METHODS: To probe premotor-motor excitability, we used a transcranial magnetic stimulation dual pulse conditioning paradigm in 15 genetically confirmed dopa-responsive dystonia patients and 20 controls under different medication states. We also determined silent periods, short-latency afferent inhibition, interhemispheric inhibition, and short-interval intracortical inhibition and facilitation.RESULTS: In contrast to healthy controls, no motor cortex inhibition was seen after premotor conditioning regardless of the dopaminergic state in patients. The duration of the ipsilateral silent period was increased in the OFF state, and short-latency afferent inhibition was reduced in the ON compared with the OFF state.CONCLUSION: Premotor-motor circuits appear hyporesponsive in dopa-responsive dystonia. © 2015 International Parkinson and Movement Disorder Society.

AB - BACKGROUND: Dopa-responsive dystonia is clinically dominated by a combination of dystonia and parkinsonism, both known to be associated with abnormal activity in premotor-motor circuits.METHODS: To probe premotor-motor excitability, we used a transcranial magnetic stimulation dual pulse conditioning paradigm in 15 genetically confirmed dopa-responsive dystonia patients and 20 controls under different medication states. We also determined silent periods, short-latency afferent inhibition, interhemispheric inhibition, and short-interval intracortical inhibition and facilitation.RESULTS: In contrast to healthy controls, no motor cortex inhibition was seen after premotor conditioning regardless of the dopaminergic state in patients. The duration of the ipsilateral silent period was increased in the OFF state, and short-latency afferent inhibition was reduced in the ON compared with the OFF state.CONCLUSION: Premotor-motor circuits appear hyporesponsive in dopa-responsive dystonia. © 2015 International Parkinson and Movement Disorder Society.

U2 - 10.1002/mds.26365

DO - 10.1002/mds.26365

M3 - SCORING: Journal article

C2 - 26230973

VL - 30

SP - 1705

EP - 1709

JO - MOVEMENT DISORD

JF - MOVEMENT DISORD

SN - 0885-3185

IS - 12

ER -