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Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease.

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Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease. / Reetz, K; Siebner, H R; Gaser, C; Hagenah, J; Büchel, Christian; Kasten, M; Petersen, D; Pramstaller, P P; Klein, C; Binkofksi, F.

In: Open Neuroimag J, Vol. 2, 2008, p. 102-105.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Reetz, K, Siebner, HR, Gaser, C, Hagenah, J, Büchel, C, Kasten, M, Petersen, D, Pramstaller, PP, Klein, C & Binkofksi, F 2008, 'Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease.', Open Neuroimag J, vol. 2, pp. 102-105. <http://www.ncbi.nlm.nih.gov/pubmed/19526072?dopt=Citation>

APA

Reetz, K., Siebner, H. R., Gaser, C., Hagenah, J., Büchel, C., Kasten, M., Petersen, D., Pramstaller, P. P., Klein, C., & Binkofksi, F. (2008). Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease. Open Neuroimag J, 2, 102-105. http://www.ncbi.nlm.nih.gov/pubmed/19526072?dopt=Citation

Vancouver

Reetz K, Siebner HR, Gaser C, Hagenah J, Büchel C, Kasten M et al. Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease. Open Neuroimag J. 2008;2:102-105.

Bibtex

@article{a5e1b913424946058fe82258bdf6af54,
title = "Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease.",
abstract = "In the present voxel-based morphometric study, we investigated whether the severity and duration of disease are associated with alterations in gray matter volume (GMV) in symptomatic Parkin mutation carriers (sPARKIN-MC) and patients with idiopathic Parkinson's disease (iPD). Regression analyses revealed different negative correlations between GMV in cortical motor areas and the severity as well as the disease duration in sPARKIN-MC and iPD patients. SPARKIN-MC showed a less involvement of cortical motor areas, in particular in the supplementary motor area (SMA) than iPD patients. Specifically, in iPD patients, but not in sPARKIN-MC, there was a negative correlation between the SMA degeneration and the UPDRS-II item freezing. The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies.",
author = "K Reetz and Siebner, {H R} and C Gaser and J Hagenah and Christian B{\"u}chel and M Kasten and D Petersen and Pramstaller, {P P} and C Klein and F Binkofksi",
year = "2008",
language = "Deutsch",
volume = "2",
pages = "102--105",
journal = "Open Neuroimag J",
issn = "1874-4400",
publisher = "Bentham Science Publishers B.V.",

}

RIS

TY - JOUR

T1 - Premotor Gray Matter Volume is Associated with Clinical Findings in Idiopathic and Genetically Determined Parkinson's Disease.

AU - Reetz, K

AU - Siebner, H R

AU - Gaser, C

AU - Hagenah, J

AU - Büchel, Christian

AU - Kasten, M

AU - Petersen, D

AU - Pramstaller, P P

AU - Klein, C

AU - Binkofksi, F

PY - 2008

Y1 - 2008

N2 - In the present voxel-based morphometric study, we investigated whether the severity and duration of disease are associated with alterations in gray matter volume (GMV) in symptomatic Parkin mutation carriers (sPARKIN-MC) and patients with idiopathic Parkinson's disease (iPD). Regression analyses revealed different negative correlations between GMV in cortical motor areas and the severity as well as the disease duration in sPARKIN-MC and iPD patients. SPARKIN-MC showed a less involvement of cortical motor areas, in particular in the supplementary motor area (SMA) than iPD patients. Specifically, in iPD patients, but not in sPARKIN-MC, there was a negative correlation between the SMA degeneration and the UPDRS-II item freezing. The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies.

AB - In the present voxel-based morphometric study, we investigated whether the severity and duration of disease are associated with alterations in gray matter volume (GMV) in symptomatic Parkin mutation carriers (sPARKIN-MC) and patients with idiopathic Parkinson's disease (iPD). Regression analyses revealed different negative correlations between GMV in cortical motor areas and the severity as well as the disease duration in sPARKIN-MC and iPD patients. SPARKIN-MC showed a less involvement of cortical motor areas, in particular in the supplementary motor area (SMA) than iPD patients. Specifically, in iPD patients, but not in sPARKIN-MC, there was a negative correlation between the SMA degeneration and the UPDRS-II item freezing. The different degeneration patterns may mirror diverse kinetics of the disease progress in these two groups of PD patients with different underlying etiologies.

M3 - SCORING: Zeitschriftenaufsatz

VL - 2

SP - 102

EP - 105

JO - Open Neuroimag J

JF - Open Neuroimag J

SN - 1874-4400

ER -