Preliminary data of a HAMD-17 validated symptom scale derived from the ICD-10 to diagnose depression in outpatients
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Preliminary data of a HAMD-17 validated symptom scale derived from the ICD-10 to diagnose depression in outpatients. / Melzer, Jörg; Rostock, Matthias; Brignoli, Reto; Keck, Martin E; Saller, Reinhard.
In: FORSCH KOMPLEMENTMED, Vol. 19, No. 4, 2012, p. 191-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Preliminary data of a HAMD-17 validated symptom scale derived from the ICD-10 to diagnose depression in outpatients
AU - Melzer, Jörg
AU - Rostock, Matthias
AU - Brignoli, Reto
AU - Keck, Martin E
AU - Saller, Reinhard
N1 - Copyright © 2012 S. Karger AG, Basel.
PY - 2012
Y1 - 2012
N2 - BACKGROUND: In outpatient settings diagnostic classification of depressive symptoms is mostly descriptive based on ICD-10. Depending on clinical experience and consultation time, diagnosis can be verified by validated scales. However, physicians working in primary care are familiar with ICD-10 criteria. Therefore, the aim of the present study was to examine the feasibility of the validation of an ICD-10-derived symptom scale for depression.METHODS: For this preliminary trial we generated a symptom scale derived 1:1 from the diagnostic criteria for depression given in the ICD-10 with 10 items. The Hamilton Rating Scale for Depression (HAMD-17) was used as reference in a population of 226 outpatients suffering from depressive symptoms. Correlation between scales as well as sensitivity and specificity of the ICD-10 scale were calculated.RESULTS: The generated ICD-10 symptom scale for depression could be analyzed in 219 patients and showed a significant and strong correlation with the HAMD-17 (p < 0.0001; ρ = 0.75). The best tradeoffs between specificity and sensitivity of the ICD-10 score were found at 10 points for the lower and 14 points for the upper cut-off. Overall sensitivity and specificity was 76.7 and 88.6%. Almost two thirds (i.e. 65.3%) of the patients were correctly classified by the ICD-10 scale.CONCLUSION: The ICD-10 symptom scale examined in the current population was found to have fair correlation with the HAMD-17 as well as, in face of the limited variance of the patients' condition, acceptable sensitivity and specificity. Therefore, this preliminary study showed that the ICD-10-derived symptom scale seems appropriate to be investigated in a thorough validation trial.
AB - BACKGROUND: In outpatient settings diagnostic classification of depressive symptoms is mostly descriptive based on ICD-10. Depending on clinical experience and consultation time, diagnosis can be verified by validated scales. However, physicians working in primary care are familiar with ICD-10 criteria. Therefore, the aim of the present study was to examine the feasibility of the validation of an ICD-10-derived symptom scale for depression.METHODS: For this preliminary trial we generated a symptom scale derived 1:1 from the diagnostic criteria for depression given in the ICD-10 with 10 items. The Hamilton Rating Scale for Depression (HAMD-17) was used as reference in a population of 226 outpatients suffering from depressive symptoms. Correlation between scales as well as sensitivity and specificity of the ICD-10 scale were calculated.RESULTS: The generated ICD-10 symptom scale for depression could be analyzed in 219 patients and showed a significant and strong correlation with the HAMD-17 (p < 0.0001; ρ = 0.75). The best tradeoffs between specificity and sensitivity of the ICD-10 score were found at 10 points for the lower and 14 points for the upper cut-off. Overall sensitivity and specificity was 76.7 and 88.6%. Almost two thirds (i.e. 65.3%) of the patients were correctly classified by the ICD-10 scale.CONCLUSION: The ICD-10 symptom scale examined in the current population was found to have fair correlation with the HAMD-17 as well as, in face of the limited variance of the patients' condition, acceptable sensitivity and specificity. Therefore, this preliminary study showed that the ICD-10-derived symptom scale seems appropriate to be investigated in a thorough validation trial.
KW - Adult
KW - Aged
KW - Ambulatory Care
KW - Cooperative Behavior
KW - Depressive Disorder/classification
KW - Depressive Disorder, Major/classification
KW - Feasibility Studies
KW - Female
KW - Humans
KW - Interdisciplinary Communication
KW - International Classification of Diseases
KW - Male
KW - Middle Aged
KW - Personality Inventory/statistics & numerical data
KW - Psychometrics/statistics & numerical data
KW - Reference Values
KW - Reproducibility of Results
KW - Statistics as Topic
KW - Young Adult
U2 - 10.1159/000342018
DO - 10.1159/000342018
M3 - SCORING: Journal article
C2 - 22964985
VL - 19
SP - 191
EP - 196
JO - FORSCH KOMPLEMENTMED
JF - FORSCH KOMPLEMENTMED
SN - 1661-4119
IS - 4
ER -
