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Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice

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Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice. / Schepanski, Steven; Chini, Mattia; Sternemann, Veronika; Urbschat, Christopher; Thiele, Kristin; Sun, Ting; Zhao, Yu; Poburski, Mareike; Woestemeier, Anna; Thieme, Marie-Theres; Zazara, Dimitra E; Alawi, Malik; Fischer, Nicole; Heeren, Joerg; Vladimirov, Nikita; Woehler, Andrew; Puelles, Victor G; Bonn, Stefan; Gagliani, Nicola; Hanganu-Opatz, Ileana L; Arck, Petra C.

In: NAT COMMUN, Vol. 13, No. 1, 4571, 05.08.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schepanski, S, Chini, M, Sternemann, V, Urbschat, C, Thiele, K, Sun, T, Zhao, Y, Poburski, M, Woestemeier, A, Thieme, M-T, Zazara, DE, Alawi, M, Fischer, N, Heeren, J, Vladimirov, N, Woehler, A, Puelles, VG, Bonn, S, Gagliani, N, Hanganu-Opatz, IL & Arck, PC 2022, 'Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice', NAT COMMUN, vol. 13, no. 1, 4571. https://doi.org/10.1038/s41467-022-32230-2

APA

Schepanski, S., Chini, M., Sternemann, V., Urbschat, C., Thiele, K., Sun, T., Zhao, Y., Poburski, M., Woestemeier, A., Thieme, M-T., Zazara, D. E., Alawi, M., Fischer, N., Heeren, J., Vladimirov, N., Woehler, A., Puelles, V. G., Bonn, S., Gagliani, N., ... Arck, P. C. (2022). Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice. NAT COMMUN, 13(1), [4571]. https://doi.org/10.1038/s41467-022-32230-2

Vancouver

Schepanski S, Chini M, Sternemann V, Urbschat C, Thiele K, Sun T et al. Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice. NAT COMMUN. 2022 Aug 5;13(1). 4571. https://doi.org/10.1038/s41467-022-32230-2

Bibtex

@article{3529a3abce2e420491bbdef505eccd98,
title = "Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice",
abstract = "Life-long brain function and mental health are critically determined by developmental processes occurring before birth. During mammalian pregnancy, maternal cells are transferred to the fetus. They are referred to as maternal microchimeric cells (MMc). Among other organs, MMc seed into the fetal brain, where their function is unknown. Here, we show that, in the offspring's developing brain in mice, MMc express a unique signature of sensome markers, control microglia homeostasis and prevent excessive presynaptic elimination. Further, MMc facilitate the oscillatory entrainment of developing prefrontal-hippocampal circuits and support the maturation of behavioral abilities. Our findings highlight that MMc are not a mere placental leak out, but rather a functional mechanism that shapes optimal conditions for healthy brain function later in life.",
author = "Steven Schepanski and Mattia Chini and Veronika Sternemann and Christopher Urbschat and Kristin Thiele and Ting Sun and Yu Zhao and Mareike Poburski and Anna Woestemeier and Marie-Theres Thieme and Zazara, {Dimitra E} and Malik Alawi and Nicole Fischer and Joerg Heeren and Nikita Vladimirov and Andrew Woehler and Puelles, {Victor G} and Stefan Bonn and Nicola Gagliani and Hanganu-Opatz, {Ileana L} and Arck, {Petra C}",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = aug,
day = "5",
doi = "10.1038/s41467-022-32230-2",
language = "English",
volume = "13",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice

AU - Schepanski, Steven

AU - Chini, Mattia

AU - Sternemann, Veronika

AU - Urbschat, Christopher

AU - Thiele, Kristin

AU - Sun, Ting

AU - Zhao, Yu

AU - Poburski, Mareike

AU - Woestemeier, Anna

AU - Thieme, Marie-Theres

AU - Zazara, Dimitra E

AU - Alawi, Malik

AU - Fischer, Nicole

AU - Heeren, Joerg

AU - Vladimirov, Nikita

AU - Woehler, Andrew

AU - Puelles, Victor G

AU - Bonn, Stefan

AU - Gagliani, Nicola

AU - Hanganu-Opatz, Ileana L

AU - Arck, Petra C

N1 - © 2022. The Author(s).

PY - 2022/8/5

Y1 - 2022/8/5

N2 - Life-long brain function and mental health are critically determined by developmental processes occurring before birth. During mammalian pregnancy, maternal cells are transferred to the fetus. They are referred to as maternal microchimeric cells (MMc). Among other organs, MMc seed into the fetal brain, where their function is unknown. Here, we show that, in the offspring's developing brain in mice, MMc express a unique signature of sensome markers, control microglia homeostasis and prevent excessive presynaptic elimination. Further, MMc facilitate the oscillatory entrainment of developing prefrontal-hippocampal circuits and support the maturation of behavioral abilities. Our findings highlight that MMc are not a mere placental leak out, but rather a functional mechanism that shapes optimal conditions for healthy brain function later in life.

AB - Life-long brain function and mental health are critically determined by developmental processes occurring before birth. During mammalian pregnancy, maternal cells are transferred to the fetus. They are referred to as maternal microchimeric cells (MMc). Among other organs, MMc seed into the fetal brain, where their function is unknown. Here, we show that, in the offspring's developing brain in mice, MMc express a unique signature of sensome markers, control microglia homeostasis and prevent excessive presynaptic elimination. Further, MMc facilitate the oscillatory entrainment of developing prefrontal-hippocampal circuits and support the maturation of behavioral abilities. Our findings highlight that MMc are not a mere placental leak out, but rather a functional mechanism that shapes optimal conditions for healthy brain function later in life.

U2 - 10.1038/s41467-022-32230-2

DO - 10.1038/s41467-022-32230-2

M3 - SCORING: Journal article

C2 - 35931682

VL - 13

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

M1 - 4571

ER -