Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC)

Oktay Tutarel; Lucia Baris; Werner Budts; Mohamad Gamal Abd-El Aziz; Csilla Liptai; David Majdalany; Silvana Jovanova; Alexandra Frogoudaki; Heidi M Connolly; Mark R Johnson; Aldo P Maggioni; Roger Hall; Jolien W Roos-Hesselink; ROPAC investigators group

doi:10.1136/heartjnl-2020-318685

Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC)

Standard

Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC). / Tutarel, Oktay; Baris, Lucia; Budts, Werner; Gamal Abd-El Aziz, Mohamad; Liptai, Csilla; Majdalany, David; Jovanova, Silvana; Frogoudaki, Alexandra; Connolly, Heidi M; Johnson, Mark R; Maggioni, Aldo P; Hall, Roger; Roos-Hesselink, Jolien W; ROPAC investigators group.

In: HEART, Vol. 108, No. 2, 01.2022, p. 117-123.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tutarel, O, Baris, L, Budts, W, Gamal Abd-El Aziz, M, Liptai, C, Majdalany, D, Jovanova, S, Frogoudaki, A, Connolly, HM, Johnson, MR, Maggioni, AP, Hall, R, Roos-Hesselink, JW & ROPAC investigators group 2022, 'Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC)', HEART, vol. 108, no. 2, pp. 117-123. https://doi.org/10.1136/heartjnl-2020-318685

APA

Tutarel, O., Baris, L., Budts, W., Gamal Abd-El Aziz, M., Liptai, C., Majdalany, D., Jovanova, S., Frogoudaki, A., Connolly, H. M., Johnson, M. R., Maggioni, A. P., Hall, R., Roos-Hesselink, J. W., & ROPAC investigators group (2022). Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC). HEART, 108(2), 117-123. https://doi.org/10.1136/heartjnl-2020-318685

Vancouver

Tutarel O, Baris L, Budts W, Gamal Abd-El Aziz M, Liptai C, Majdalany D et al. Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC). HEART. 2022 Jan;108(2):117-123. https://doi.org/10.1136/heartjnl-2020-318685

Bibtex

@article{9de7fa3a1bde499583afb16c29a98dd1,

title = "Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC)",

abstract = "OBJECTIVE: Cardiac disease is a major cause of maternal mortality. Data regarding pregnancy outcomes in women with a systemic right ventricle (sRV) are scarce. We studied pregnancy outcomes in women with an sRV after the atrial switch procedure for transposition of the great arteries (TGA) or congenitally corrected TGA (CCTGA).METHODS: The ESC EORP Registry of Pregnancy and Cardiac Disease is an international prospective registry of pregnant women with cardiac disease. Pregnancy outcomes (maternal/fetal) in all women with an sRV are described. The primary end point was a major adverse cardiac event (MACE) defined as maternal death, supraventricular or ventricular arrhythmias requiring treatment, heart failure, aortic dissection, endocarditis, ischaemic coronary event and other thromboembolic events.RESULTS: Altogether, 162 women with an sRV (TGA n=121, CCTGA n=41, mean age 28.8±4.6 years) were included. No maternal mortality occurred. In 26 women, at least one MACE occurred, heart failure in 16 (9.8%), arrhythmias (atrial 5, ventricular 6) in 11 (6.7%) and others in 4 (2.5%). Prepregnancy signs of heart failure as well as an sRV ejection fraction <40% were predictors of MACE. One woman experienced fetal loss, while no neonatal mortality was observed. No significant differences were found between women with CCTGA and TGA. In the subset of women who had an echocardiogram before and after pregnancy, no clear deterioration in sRV was observed.CONCLUSION: The majority of women with an sRV tolerated pregnancy well with a favourable maternal and fetal outcome. Heart failure and arrhythmias were the most common MACE.",

author = "Oktay Tutarel and Lucia Baris and Werner Budts and {Gamal Abd-El Aziz}, Mohamad and Csilla Liptai and David Majdalany and Silvana Jovanova and Alexandra Frogoudaki and Connolly, {Heidi M} and Johnson, {Mark R} and Maggioni, {Aldo P} and Roger Hall and Roos-Hesselink, {Jolien W} and {ROPAC investigators group} and Sinning, {Christoph Robert} and Rainer Kozlik-Feldmann and Stefan Blankenberg and Elvin Zengin-Sahm and G{\"o}tz M{\"u}ller and Mathias Hillebrand and Hauck, {Peer Alexander} and {von Kodolitsch}, Yskert",

note = "{\textcopyright} Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.",

year = "2022",

month = jan,

doi = "10.1136/heartjnl-2020-318685",

language = "English",

volume = "108",

pages = "117--123",

journal = "HEART",

issn = "1355-6037",

publisher = "BMJ PUBLISHING GROUP",

number = "2",

}

RIS

TY - JOUR

T1 - Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC)

AU - Tutarel, Oktay

AU - Baris, Lucia

AU - Budts, Werner

AU - Gamal Abd-El Aziz, Mohamad

AU - Liptai, Csilla

AU - Majdalany, David

AU - Jovanova, Silvana

AU - Frogoudaki, Alexandra

AU - Connolly, Heidi M

AU - Johnson, Mark R

AU - Maggioni, Aldo P

AU - Hall, Roger

AU - Roos-Hesselink, Jolien W

AU - ROPAC investigators group

AU - Sinning, Christoph Robert

AU - Kozlik-Feldmann, Rainer

AU - Blankenberg, Stefan

AU - Zengin-Sahm, Elvin

AU - Müller, Götz

AU - Hillebrand, Mathias

AU - Hauck, Peer Alexander

AU - von Kodolitsch, Yskert

PY - 2022/1

Y1 - 2022/1

N2 - OBJECTIVE: Cardiac disease is a major cause of maternal mortality. Data regarding pregnancy outcomes in women with a systemic right ventricle (sRV) are scarce. We studied pregnancy outcomes in women with an sRV after the atrial switch procedure for transposition of the great arteries (TGA) or congenitally corrected TGA (CCTGA).METHODS: The ESC EORP Registry of Pregnancy and Cardiac Disease is an international prospective registry of pregnant women with cardiac disease. Pregnancy outcomes (maternal/fetal) in all women with an sRV are described. The primary end point was a major adverse cardiac event (MACE) defined as maternal death, supraventricular or ventricular arrhythmias requiring treatment, heart failure, aortic dissection, endocarditis, ischaemic coronary event and other thromboembolic events.RESULTS: Altogether, 162 women with an sRV (TGA n=121, CCTGA n=41, mean age 28.8±4.6 years) were included. No maternal mortality occurred. In 26 women, at least one MACE occurred, heart failure in 16 (9.8%), arrhythmias (atrial 5, ventricular 6) in 11 (6.7%) and others in 4 (2.5%). Prepregnancy signs of heart failure as well as an sRV ejection fraction <40% were predictors of MACE. One woman experienced fetal loss, while no neonatal mortality was observed. No significant differences were found between women with CCTGA and TGA. In the subset of women who had an echocardiogram before and after pregnancy, no clear deterioration in sRV was observed.CONCLUSION: The majority of women with an sRV tolerated pregnancy well with a favourable maternal and fetal outcome. Heart failure and arrhythmias were the most common MACE.

AB - OBJECTIVE: Cardiac disease is a major cause of maternal mortality. Data regarding pregnancy outcomes in women with a systemic right ventricle (sRV) are scarce. We studied pregnancy outcomes in women with an sRV after the atrial switch procedure for transposition of the great arteries (TGA) or congenitally corrected TGA (CCTGA).METHODS: The ESC EORP Registry of Pregnancy and Cardiac Disease is an international prospective registry of pregnant women with cardiac disease. Pregnancy outcomes (maternal/fetal) in all women with an sRV are described. The primary end point was a major adverse cardiac event (MACE) defined as maternal death, supraventricular or ventricular arrhythmias requiring treatment, heart failure, aortic dissection, endocarditis, ischaemic coronary event and other thromboembolic events.RESULTS: Altogether, 162 women with an sRV (TGA n=121, CCTGA n=41, mean age 28.8±4.6 years) were included. No maternal mortality occurred. In 26 women, at least one MACE occurred, heart failure in 16 (9.8%), arrhythmias (atrial 5, ventricular 6) in 11 (6.7%) and others in 4 (2.5%). Prepregnancy signs of heart failure as well as an sRV ejection fraction <40% were predictors of MACE. One woman experienced fetal loss, while no neonatal mortality was observed. No significant differences were found between women with CCTGA and TGA. In the subset of women who had an echocardiogram before and after pregnancy, no clear deterioration in sRV was observed.CONCLUSION: The majority of women with an sRV tolerated pregnancy well with a favourable maternal and fetal outcome. Heart failure and arrhythmias were the most common MACE.

U2 - 10.1136/heartjnl-2020-318685

DO - 10.1136/heartjnl-2020-318685

M3 - SCORING: Journal article

C2 - 33911009

VL - 108

SP - 117

EP - 123

JO - HEART

JF - HEART

SN - 1355-6037

IS - 2

ER -