Predominant cutaneous infiltration by OKT6- and OKT8-positive cells in a case of Sézary syndrome.
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Predominant cutaneous infiltration by OKT6- and OKT8-positive cells in a case of Sézary syndrome. / Meissner, K; Löning, Thomas; Heckmayr, M; Zschaber, R; Jänner, M.
In: ARCH DERMATOL RES, Vol. 275, No. 3, 3, 1983, p. 168-174.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Predominant cutaneous infiltration by OKT6- and OKT8-positive cells in a case of Sézary syndrome.
AU - Meissner, K
AU - Löning, Thomas
AU - Heckmayr, M
AU - Zschaber, R
AU - Jänner, M
PY - 1983
Y1 - 1983
N2 - Using an immunoperoxidase (skin biopsy) and an immunofluorescence (peripheral blood, bone marrow punctate) technique, and monoclonal antibodies raised against peripheral mature lymphocytes, T helper subsets, T suppressor subsets, and Langerhans cells, we found a predominant dermal infiltration with lymphocytes of the suppressor phenotype and a predominant epidermal infiltration with Langerhans cells in a patient with Sézary syndrome (cutaneous T-cell lymphoma, CTCL). Repeated peripheral blood examinations showed an increased percentage of lymphocytes of the helper phenotype. A bone marrow examination revealed a ratio of suppressor/helper subsets of 1:4. The findings in the skin seem to be inconsistent with most of the results of previous studies in patients with CTCL; the significance of these findings is discussed.
AB - Using an immunoperoxidase (skin biopsy) and an immunofluorescence (peripheral blood, bone marrow punctate) technique, and monoclonal antibodies raised against peripheral mature lymphocytes, T helper subsets, T suppressor subsets, and Langerhans cells, we found a predominant dermal infiltration with lymphocytes of the suppressor phenotype and a predominant epidermal infiltration with Langerhans cells in a patient with Sézary syndrome (cutaneous T-cell lymphoma, CTCL). Repeated peripheral blood examinations showed an increased percentage of lymphocytes of the helper phenotype. A bone marrow examination revealed a ratio of suppressor/helper subsets of 1:4. The findings in the skin seem to be inconsistent with most of the results of previous studies in patients with CTCL; the significance of these findings is discussed.
M3 - SCORING: Zeitschriftenaufsatz
VL - 275
SP - 168
EP - 174
JO - ARCH DERMATOL RES
JF - ARCH DERMATOL RES
SN - 0340-3696
IS - 3
M1 - 3
ER -
