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Predictors of poor clinical outcome despite complete reperfusion in acute ischemic stroke patients

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Predictors of poor clinical outcome despite complete reperfusion in acute ischemic stroke patients. / van Horn, Noel; Kniep, Helge; Leischner, Hannes; McDonough, Rosalie; Deb-Chatterji, Milani; Broocks, Gabriel; Thomalla, Goetz; Brekenfeld, Caspar; Fiehler, Jens; Hanning, Uta; Flottmann, Fabian.

In: J NEUROINTERV SURG, Vol. 13, No. 1, 01.2021, p. 14-18.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

van Horn, N, Kniep, H, Leischner, H, McDonough, R, Deb-Chatterji, M, Broocks, G, Thomalla, G, Brekenfeld, C, Fiehler, J, Hanning, U & Flottmann, F 2021, 'Predictors of poor clinical outcome despite complete reperfusion in acute ischemic stroke patients', J NEUROINTERV SURG, vol. 13, no. 1, pp. 14-18. https://doi.org/10.1136/neurintsurg-2020-015889

APA

van Horn, N., Kniep, H., Leischner, H., McDonough, R., Deb-Chatterji, M., Broocks, G., Thomalla, G., Brekenfeld, C., Fiehler, J., Hanning, U., & Flottmann, F. (2021). Predictors of poor clinical outcome despite complete reperfusion in acute ischemic stroke patients. J NEUROINTERV SURG, 13(1), 14-18. https://doi.org/10.1136/neurintsurg-2020-015889

Vancouver

van Horn N, Kniep H, Leischner H, McDonough R, Deb-Chatterji M, Broocks G et al. Predictors of poor clinical outcome despite complete reperfusion in acute ischemic stroke patients. J NEUROINTERV SURG. 2021 Jan;13(1):14-18. https://doi.org/10.1136/neurintsurg-2020-015889

Bibtex

@article{aa3c2f020f384de9abf6e58cf9d0b5d7,
title = "Predictors of poor clinical outcome despite complete reperfusion in acute ischemic stroke patients",
abstract = "BACKGROUND: In patients suffering from acute ischemic stroke from large vessel occlusion (LVO), mechanical thrombectomy (MT) often leads to successful reperfusion. Only approximately half of these patients have a favorable clinical outcome. Our aim was to determine the prognostic factors associated with poor clinical outcome following complete reperfusion.METHODS: Patients treated with MT for LVO from a prospective single-center stroke registry between July 2015 and April 2019 were screened. Complete reperfusion was defined as Thrombolysis in Cerebral Infarction (TICI) grade 3. A modified Rankin scale at 90 days (mRS90) of 3-6 was defined as 'poor outcome'. A logistic regression analysis was performed with poor outcome as a dependent variable, and baseline clinical data, comorbidities, stroke severity, collateral status, and treatment information as independent variables.RESULTS: 123 patients with complete reperfusion (TICI 3) were included in this study. Poor clinical outcome was observed in 67 (54.5%) of these patients. Multivariable logistic regression analysis identified greater age (adjusted OR 1.10, 95% CI 1.04 to 1.17; p=0.001), higher admission National Institutes of Health Stroke Scale (NIHSS) (OR 1.14, 95% CI 1.02 to 1.28; p=0.024), and lower Alberta Stroke Program Early CT Score (ASPECTS) (OR 0.6, 95% CI 0.4 to 0.84; p=0.007) as independent predictors of poor outcome. Poor outcome was independent of collateral score.CONCLUSION: Poor clinical outcome is observed in a large proportion of acute ischemic stroke patients treated with MT, despite complete reperfusion. In this study, futile recanalization was shown to occur independently of collateral status, but was associated with increasing age and stroke severity.",
author = "{van Horn}, Noel and Helge Kniep and Hannes Leischner and Rosalie McDonough and Milani Deb-Chatterji and Gabriel Broocks and Goetz Thomalla and Caspar Brekenfeld and Jens Fiehler and Uta Hanning and Fabian Flottmann",
note = "{\textcopyright} Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2021",
month = jan,
doi = "10.1136/neurintsurg-2020-015889",
language = "English",
volume = "13",
pages = "14--18",
journal = "J NEUROINTERV SURG",
issn = "1759-8478",
publisher = "BMJ PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Predictors of poor clinical outcome despite complete reperfusion in acute ischemic stroke patients

AU - van Horn, Noel

AU - Kniep, Helge

AU - Leischner, Hannes

AU - McDonough, Rosalie

AU - Deb-Chatterji, Milani

AU - Broocks, Gabriel

AU - Thomalla, Goetz

AU - Brekenfeld, Caspar

AU - Fiehler, Jens

AU - Hanning, Uta

AU - Flottmann, Fabian

N1 - © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/1

Y1 - 2021/1

N2 - BACKGROUND: In patients suffering from acute ischemic stroke from large vessel occlusion (LVO), mechanical thrombectomy (MT) often leads to successful reperfusion. Only approximately half of these patients have a favorable clinical outcome. Our aim was to determine the prognostic factors associated with poor clinical outcome following complete reperfusion.METHODS: Patients treated with MT for LVO from a prospective single-center stroke registry between July 2015 and April 2019 were screened. Complete reperfusion was defined as Thrombolysis in Cerebral Infarction (TICI) grade 3. A modified Rankin scale at 90 days (mRS90) of 3-6 was defined as 'poor outcome'. A logistic regression analysis was performed with poor outcome as a dependent variable, and baseline clinical data, comorbidities, stroke severity, collateral status, and treatment information as independent variables.RESULTS: 123 patients with complete reperfusion (TICI 3) were included in this study. Poor clinical outcome was observed in 67 (54.5%) of these patients. Multivariable logistic regression analysis identified greater age (adjusted OR 1.10, 95% CI 1.04 to 1.17; p=0.001), higher admission National Institutes of Health Stroke Scale (NIHSS) (OR 1.14, 95% CI 1.02 to 1.28; p=0.024), and lower Alberta Stroke Program Early CT Score (ASPECTS) (OR 0.6, 95% CI 0.4 to 0.84; p=0.007) as independent predictors of poor outcome. Poor outcome was independent of collateral score.CONCLUSION: Poor clinical outcome is observed in a large proportion of acute ischemic stroke patients treated with MT, despite complete reperfusion. In this study, futile recanalization was shown to occur independently of collateral status, but was associated with increasing age and stroke severity.

AB - BACKGROUND: In patients suffering from acute ischemic stroke from large vessel occlusion (LVO), mechanical thrombectomy (MT) often leads to successful reperfusion. Only approximately half of these patients have a favorable clinical outcome. Our aim was to determine the prognostic factors associated with poor clinical outcome following complete reperfusion.METHODS: Patients treated with MT for LVO from a prospective single-center stroke registry between July 2015 and April 2019 were screened. Complete reperfusion was defined as Thrombolysis in Cerebral Infarction (TICI) grade 3. A modified Rankin scale at 90 days (mRS90) of 3-6 was defined as 'poor outcome'. A logistic regression analysis was performed with poor outcome as a dependent variable, and baseline clinical data, comorbidities, stroke severity, collateral status, and treatment information as independent variables.RESULTS: 123 patients with complete reperfusion (TICI 3) were included in this study. Poor clinical outcome was observed in 67 (54.5%) of these patients. Multivariable logistic regression analysis identified greater age (adjusted OR 1.10, 95% CI 1.04 to 1.17; p=0.001), higher admission National Institutes of Health Stroke Scale (NIHSS) (OR 1.14, 95% CI 1.02 to 1.28; p=0.024), and lower Alberta Stroke Program Early CT Score (ASPECTS) (OR 0.6, 95% CI 0.4 to 0.84; p=0.007) as independent predictors of poor outcome. Poor outcome was independent of collateral score.CONCLUSION: Poor clinical outcome is observed in a large proportion of acute ischemic stroke patients treated with MT, despite complete reperfusion. In this study, futile recanalization was shown to occur independently of collateral status, but was associated with increasing age and stroke severity.

U2 - 10.1136/neurintsurg-2020-015889

DO - 10.1136/neurintsurg-2020-015889

M3 - SCORING: Journal article

C2 - 32414889

VL - 13

SP - 14

EP - 18

JO - J NEUROINTERV SURG

JF - J NEUROINTERV SURG

SN - 1759-8478

IS - 1

ER -