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Predictors of outcome of mitral valve prolapse in patients with the Marfan syndrome

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Predictors of outcome of mitral valve prolapse in patients with the Marfan syndrome. / Rybczynski, Meike; Treede, Hendrik; Sheikhzadeh, Sara; Groene, Eike F; Bernhardt, Alexander M J; Hillebrand, Mathias; Mir, Thomas S; Kühne, Kristine; Koschyk, Dietmar; Robinson, Peter N; Berger, Jürgen; Reichenspurner, Hermann; Meinertz, Thomas; von Kodolitsch, Yskert.

In: AM J CARDIOL, Vol. 107, No. 2, 15.01.2011, p. 268-274.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rybczynski, M, Treede, H, Sheikhzadeh, S, Groene, EF, Bernhardt, AMJ, Hillebrand, M, Mir, TS, Kühne, K, Koschyk, D, Robinson, PN, Berger, J, Reichenspurner, H, Meinertz, T & von Kodolitsch, Y 2011, 'Predictors of outcome of mitral valve prolapse in patients with the Marfan syndrome', AM J CARDIOL, vol. 107, no. 2, pp. 268-274. https://doi.org/10.1016/j.amjcard.2010.08.070

APA

Rybczynski, M., Treede, H., Sheikhzadeh, S., Groene, E. F., Bernhardt, A. M. J., Hillebrand, M., Mir, T. S., Kühne, K., Koschyk, D., Robinson, P. N., Berger, J., Reichenspurner, H., Meinertz, T., & von Kodolitsch, Y. (2011). Predictors of outcome of mitral valve prolapse in patients with the Marfan syndrome. AM J CARDIOL, 107(2), 268-274. https://doi.org/10.1016/j.amjcard.2010.08.070

Vancouver

Rybczynski M, Treede H, Sheikhzadeh S, Groene EF, Bernhardt AMJ, Hillebrand M et al. Predictors of outcome of mitral valve prolapse in patients with the Marfan syndrome. AM J CARDIOL. 2011 Jan 15;107(2):268-274. https://doi.org/10.1016/j.amjcard.2010.08.070

Bibtex

@article{564dd16860894e8b92fc9f2f6cc6bff4,
title = "Predictors of outcome of mitral valve prolapse in patients with the Marfan syndrome",
abstract = "Mitral valve prolapse has a prevalence of 2% to 3% in the general population, with adverse outcomes such as mitral valve regurgitation (MVR), heart failure, and endocarditis. Predictors of outcomes are used in idiopathic mitral valve prolapse for the timing of surgery, but such predictors are unknown in Marfan syndrome. Therefore, a population-based cohort study of 112 patients (49 male, 63 female; mean age 34 ± 15 years) with classic Marfan syndrome and mitral valve prolapse with moderate or less MVR at baseline was conducted. During 4.6 ± 3.6 years of follow-up, progression of MVR was observed in 41 patients and valve-related events, which comprised mitral valve endocarditis (7 events), heart failure (5 events), and mitral valve surgery (25 events), were observed in 31 patients. Multivariate Cox proportional-hazards regression analysis identified a flail mitral leaflet (hazard ratio [HR] 3.262, 95% confidence interval [CI] 1.406 to 7.566, p = 0.006) and increased indexed end-systolic left ventricular diameters (HR 1.113, 95% CI 1.043 to 1.188, p = 0.001) as independent predictors of progression of MVR. Similarly, mitral valve-related events were independently predicted by a flail mitral leaflet (HR 5.343, 95% CI 2.229 to 12.808, p <0.001), and mild (HR 14.336, 95% CI 1.873 to 109.755, p = 0.01) or moderate (HR 16.849, 95% CI 2.205 to 128.76, p = 0.006) degree of MVR. Conversely, aortic dilatation, dural ectasia, and sporadic mode of inheritance were not associated with outcome. In conclusion, the same clinical determinants that predict outcomes in idiopathic mitral valve prolapse also predict outcomes in mitral valve prolapse associated with Marfan syndrome.",
keywords = "Adult, Disease Progression, Echocardiography, Female, Follow-Up Studies, Heart Ventricles/diagnostic imaging, Humans, Male, Marfan Syndrome/complications, Mitral Valve Prolapse/diagnosis, Prognosis, Retrospective Studies, Stroke Volume, Time Factors, Ventricular Function, Left",
author = "Meike Rybczynski and Hendrik Treede and Sara Sheikhzadeh and Groene, {Eike F} and Bernhardt, {Alexander M J} and Mathias Hillebrand and Mir, {Thomas S} and Kristine K{\"u}hne and Dietmar Koschyk and Robinson, {Peter N} and J{\"u}rgen Berger and Hermann Reichenspurner and Thomas Meinertz and {von Kodolitsch}, Yskert",
note = "Copyright {\^A}{\textcopyright} 2011 Elsevier Inc. All rights reserved.",
year = "2011",
month = jan,
day = "15",
doi = "10.1016/j.amjcard.2010.08.070",
language = "English",
volume = "107",
pages = "268--274",
journal = "AM J CARDIOL",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Predictors of outcome of mitral valve prolapse in patients with the Marfan syndrome

AU - Rybczynski, Meike

AU - Treede, Hendrik

AU - Sheikhzadeh, Sara

AU - Groene, Eike F

AU - Bernhardt, Alexander M J

AU - Hillebrand, Mathias

AU - Mir, Thomas S

AU - Kühne, Kristine

AU - Koschyk, Dietmar

AU - Robinson, Peter N

AU - Berger, Jürgen

AU - Reichenspurner, Hermann

AU - Meinertz, Thomas

AU - von Kodolitsch, Yskert

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2011/1/15

Y1 - 2011/1/15

N2 - Mitral valve prolapse has a prevalence of 2% to 3% in the general population, with adverse outcomes such as mitral valve regurgitation (MVR), heart failure, and endocarditis. Predictors of outcomes are used in idiopathic mitral valve prolapse for the timing of surgery, but such predictors are unknown in Marfan syndrome. Therefore, a population-based cohort study of 112 patients (49 male, 63 female; mean age 34 ± 15 years) with classic Marfan syndrome and mitral valve prolapse with moderate or less MVR at baseline was conducted. During 4.6 ± 3.6 years of follow-up, progression of MVR was observed in 41 patients and valve-related events, which comprised mitral valve endocarditis (7 events), heart failure (5 events), and mitral valve surgery (25 events), were observed in 31 patients. Multivariate Cox proportional-hazards regression analysis identified a flail mitral leaflet (hazard ratio [HR] 3.262, 95% confidence interval [CI] 1.406 to 7.566, p = 0.006) and increased indexed end-systolic left ventricular diameters (HR 1.113, 95% CI 1.043 to 1.188, p = 0.001) as independent predictors of progression of MVR. Similarly, mitral valve-related events were independently predicted by a flail mitral leaflet (HR 5.343, 95% CI 2.229 to 12.808, p <0.001), and mild (HR 14.336, 95% CI 1.873 to 109.755, p = 0.01) or moderate (HR 16.849, 95% CI 2.205 to 128.76, p = 0.006) degree of MVR. Conversely, aortic dilatation, dural ectasia, and sporadic mode of inheritance were not associated with outcome. In conclusion, the same clinical determinants that predict outcomes in idiopathic mitral valve prolapse also predict outcomes in mitral valve prolapse associated with Marfan syndrome.

AB - Mitral valve prolapse has a prevalence of 2% to 3% in the general population, with adverse outcomes such as mitral valve regurgitation (MVR), heart failure, and endocarditis. Predictors of outcomes are used in idiopathic mitral valve prolapse for the timing of surgery, but such predictors are unknown in Marfan syndrome. Therefore, a population-based cohort study of 112 patients (49 male, 63 female; mean age 34 ± 15 years) with classic Marfan syndrome and mitral valve prolapse with moderate or less MVR at baseline was conducted. During 4.6 ± 3.6 years of follow-up, progression of MVR was observed in 41 patients and valve-related events, which comprised mitral valve endocarditis (7 events), heart failure (5 events), and mitral valve surgery (25 events), were observed in 31 patients. Multivariate Cox proportional-hazards regression analysis identified a flail mitral leaflet (hazard ratio [HR] 3.262, 95% confidence interval [CI] 1.406 to 7.566, p = 0.006) and increased indexed end-systolic left ventricular diameters (HR 1.113, 95% CI 1.043 to 1.188, p = 0.001) as independent predictors of progression of MVR. Similarly, mitral valve-related events were independently predicted by a flail mitral leaflet (HR 5.343, 95% CI 2.229 to 12.808, p <0.001), and mild (HR 14.336, 95% CI 1.873 to 109.755, p = 0.01) or moderate (HR 16.849, 95% CI 2.205 to 128.76, p = 0.006) degree of MVR. Conversely, aortic dilatation, dural ectasia, and sporadic mode of inheritance were not associated with outcome. In conclusion, the same clinical determinants that predict outcomes in idiopathic mitral valve prolapse also predict outcomes in mitral valve prolapse associated with Marfan syndrome.

KW - Adult

KW - Disease Progression

KW - Echocardiography

KW - Female

KW - Follow-Up Studies

KW - Heart Ventricles/diagnostic imaging

KW - Humans

KW - Male

KW - Marfan Syndrome/complications

KW - Mitral Valve Prolapse/diagnosis

KW - Prognosis

KW - Retrospective Studies

KW - Stroke Volume

KW - Time Factors

KW - Ventricular Function, Left

U2 - 10.1016/j.amjcard.2010.08.070

DO - 10.1016/j.amjcard.2010.08.070

M3 - SCORING: Journal article

C2 - 21211604

VL - 107

SP - 268

EP - 274

JO - AM J CARDIOL

JF - AM J CARDIOL

SN - 0002-9149

IS - 2

ER -