Predictors of neonatal outcome in early-onset placental dysfunction.
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Predictors of neonatal outcome in early-onset placental dysfunction. / Baschat, Ahmet; Cosmi, Erich; Bilardo, Catarina M; Wolf, Hans; Berg, Christoph; Rigano, Serena; Germer, Ute; Moyano, Dolores; Turan, Sifa; Hartung, John; Bhide, Amarnath; Müller, Thomas; Bower, Sarah; Nicolaides, Kypros H; Thilaganathan, Baskaran; Gembruch, Ulrich; Ferrazzi, Enrico; Hecher, Kurt; Galan, Henry L; Harman, Chris R.
In: OBSTET GYNECOL, Vol. 109(2 Pt 1), 2007, p. 253-261.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Predictors of neonatal outcome in early-onset placental dysfunction.
AU - Baschat, Ahmet
AU - Cosmi, Erich
AU - Bilardo, Catarina M
AU - Wolf, Hans
AU - Berg, Christoph
AU - Rigano, Serena
AU - Germer, Ute
AU - Moyano, Dolores
AU - Turan, Sifa
AU - Hartung, John
AU - Bhide, Amarnath
AU - Müller, Thomas
AU - Bower, Sarah
AU - Nicolaides, Kypros H
AU - Thilaganathan, Baskaran
AU - Gembruch, Ulrich
AU - Ferrazzi, Enrico
AU - Hecher, Kurt
AU - Galan, Henry L
AU - Harman, Chris R
PY - 2007
Y1 - 2007
N2 - OBJECTIVE: To identify specific estimates and predictors of neonatal morbidity and mortality in early onset fetal growth restriction due to placental dysfunction. METHODS: Prospective multicenter study of prenatally diagnosed growth-restricted liveborn neonates of less than 33 weeks of gestational age. Relationships between perinatal variables (arterial and venous Dopplers, gestational age, birth weight, acid-base status, and Apgar scores) and major neonatal complications, neonatal death, and intact survival were analyzed by logistic regression. Predictive cutoffs were determined by receiver operating characteristic curves. RESULTS: Major morbidity occurred in 35.9% of 604 neonates: bronchopulmonary dysplasia in 23.2% (n=140), intraventricular hemorrhage in 15.2% (n=92), and necrotizing enterocolitis in 12.4% (n=75). Total mortality was 21.5 % (n=130), and 58.3% survived without complication (n=352). From 24 to 32 weeks, major morbidity declined (56.6% to 10.5%), coinciding with survival that exceeded 50% after 26 weeks. Gestational age was the most significant determinant (P
AB - OBJECTIVE: To identify specific estimates and predictors of neonatal morbidity and mortality in early onset fetal growth restriction due to placental dysfunction. METHODS: Prospective multicenter study of prenatally diagnosed growth-restricted liveborn neonates of less than 33 weeks of gestational age. Relationships between perinatal variables (arterial and venous Dopplers, gestational age, birth weight, acid-base status, and Apgar scores) and major neonatal complications, neonatal death, and intact survival were analyzed by logistic regression. Predictive cutoffs were determined by receiver operating characteristic curves. RESULTS: Major morbidity occurred in 35.9% of 604 neonates: bronchopulmonary dysplasia in 23.2% (n=140), intraventricular hemorrhage in 15.2% (n=92), and necrotizing enterocolitis in 12.4% (n=75). Total mortality was 21.5 % (n=130), and 58.3% survived without complication (n=352). From 24 to 32 weeks, major morbidity declined (56.6% to 10.5%), coinciding with survival that exceeded 50% after 26 weeks. Gestational age was the most significant determinant (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 109(2 Pt 1)
SP - 253
EP - 261
ER -