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Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

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Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. / Lorenz, Matthias W; Gao, Lu; Ziegelbauer, Kathrin; Norata, Giuseppe Danilo; Empana, Jean Philippe; Schmidtmann, Irene; Lin, Hung-Ju; McLachlan, Stela; Bokemark, Lena; Ronkainen, Kimmo; Amato, Mauro; Schminke, Ulf; Srinivasan, Sathanur R; Lind, Lars; Okazaki, Shuhei; Stehouwer, Coen D A; Willeit, Peter; Polak, Joseph F; Steinmetz, Helmuth; Sander, Dirk; Poppert, Holger; Desvarieux, Moise; Ikram, M Arfan; Johnsen, Stein Harald; Staub, Daniel; Sirtori, Cesare R; Iglseder, Bernhard; Beloqui, Oscar; Engström, Gunnar; Friera, Alfonso; Rozza, Francesco; Xie, Wuxiang; Parraga, Grace; Grigore, Liliana; Plichart, Matthieu; Blankenberg, Stefan; Su, Ta-Chen; Schmidt, Caroline; Tuomainen, Tomi-Pekka; Veglia, Fabrizio; Völzke, Henry; Nijpels, Giel; Willeit, Johann; Sacco, Ralph L; Franco, Oscar H; Uthoff, Heiko; Hedblad, Bo; Suarez, Carmen; Izzo, Raffaele; Zhao, Dong; Wannarong, Thapat; Catapano, Alberico; Ducimetiere, Pierre; Espinola-Klein, Christine; Chien, Kuo-Liong; Price, Jackie F; Bergström, Göran; Kauhanen, Jussi; Tremoli, Elena; Dörr, Marcus; Berenson, Gerald; Kitagawa, Kazuo; Dekker, Jacqueline M; Kiechl, Stefan; Sitzer, Matthias; Bickel, Horst; Rundek, Tatjana; Hofman, Albert; Mathiesen, Ellisiv B; Castelnuovo, Samuela; Landecho, Manuel F; Rosvall, Maria; Gabriel, Rafael; de Luca, Nicola; Liu, Jing; Baldassarre, Damiano; Kavousi, Maryam; de Groot, Eric; Bots, Michiel L; Yanez, David N; Thompson, Simon G; PROG-IMT study group.

In: PLOS ONE, Vol. 13, No. 4, 2018, p. e0191172.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lorenz, MW, Gao, L, Ziegelbauer, K, Norata, GD, Empana, JP, Schmidtmann, I, Lin, H-J, McLachlan, S, Bokemark, L, Ronkainen, K, Amato, M, Schminke, U, Srinivasan, SR, Lind, L, Okazaki, S, Stehouwer, CDA, Willeit, P, Polak, JF, Steinmetz, H, Sander, D, Poppert, H, Desvarieux, M, Ikram, MA, Johnsen, SH, Staub, D, Sirtori, CR, Iglseder, B, Beloqui, O, Engström, G, Friera, A, Rozza, F, Xie, W, Parraga, G, Grigore, L, Plichart, M, Blankenberg, S, Su, T-C, Schmidt, C, Tuomainen, T-P, Veglia, F, Völzke, H, Nijpels, G, Willeit, J, Sacco, RL, Franco, OH, Uthoff, H, Hedblad, B, Suarez, C, Izzo, R, Zhao, D, Wannarong, T, Catapano, A, Ducimetiere, P, Espinola-Klein, C, Chien, K-L, Price, JF, Bergström, G, Kauhanen, J, Tremoli, E, Dörr, M, Berenson, G, Kitagawa, K, Dekker, JM, Kiechl, S, Sitzer, M, Bickel, H, Rundek, T, Hofman, A, Mathiesen, EB, Castelnuovo, S, Landecho, MF, Rosvall, M, Gabriel, R, de Luca, N, Liu, J, Baldassarre, D, Kavousi, M, de Groot, E, Bots, ML, Yanez, DN, Thompson, SG & PROG-IMT study group 2018, 'Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration', PLOS ONE, vol. 13, no. 4, pp. e0191172. https://doi.org/10.1371/journal.pone.0191172

APA

Lorenz, M. W., Gao, L., Ziegelbauer, K., Norata, G. D., Empana, J. P., Schmidtmann, I., Lin, H-J., McLachlan, S., Bokemark, L., Ronkainen, K., Amato, M., Schminke, U., Srinivasan, S. R., Lind, L., Okazaki, S., Stehouwer, C. D. A., Willeit, P., Polak, J. F., Steinmetz, H., ... PROG-IMT study group (2018). Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. PLOS ONE, 13(4), e0191172. https://doi.org/10.1371/journal.pone.0191172

Vancouver

Lorenz MW, Gao L, Ziegelbauer K, Norata GD, Empana JP, Schmidtmann I et al. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. PLOS ONE. 2018;13(4):e0191172. https://doi.org/10.1371/journal.pone.0191172

Bibtex

@article{45bb7e1456ed456ba386e853f06757f6,
title = "Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration",
abstract = "AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk.METHODS AND RESULTS: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C.CONCLUSIONS: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.",
keywords = "Aged, Cardiovascular Diseases/diagnosis, Carotid Intima-Media Thickness, Female, Humans, Intersectoral Collaboration, Male, Middle Aged, Prognosis, Risk Factors",
author = "Lorenz, {Matthias W} and Lu Gao and Kathrin Ziegelbauer and Norata, {Giuseppe Danilo} and Empana, {Jean Philippe} and Irene Schmidtmann and Hung-Ju Lin and Stela McLachlan and Lena Bokemark and Kimmo Ronkainen and Mauro Amato and Ulf Schminke and Srinivasan, {Sathanur R} and Lars Lind and Shuhei Okazaki and Stehouwer, {Coen D A} and Peter Willeit and Polak, {Joseph F} and Helmuth Steinmetz and Dirk Sander and Holger Poppert and Moise Desvarieux and Ikram, {M Arfan} and Johnsen, {Stein Harald} and Daniel Staub and Sirtori, {Cesare R} and Bernhard Iglseder and Oscar Beloqui and Gunnar Engstr{\"o}m and Alfonso Friera and Francesco Rozza and Wuxiang Xie and Grace Parraga and Liliana Grigore and Matthieu Plichart and Stefan Blankenberg and Ta-Chen Su and Caroline Schmidt and Tomi-Pekka Tuomainen and Fabrizio Veglia and Henry V{\"o}lzke and Giel Nijpels and Johann Willeit and Sacco, {Ralph L} and Franco, {Oscar H} and Heiko Uthoff and Bo Hedblad and Carmen Suarez and Raffaele Izzo and Dong Zhao and Thapat Wannarong and Alberico Catapano and Pierre Ducimetiere and Christine Espinola-Klein and Kuo-Liong Chien and Price, {Jackie F} and G{\"o}ran Bergstr{\"o}m and Jussi Kauhanen and Elena Tremoli and Marcus D{\"o}rr and Gerald Berenson and Kazuo Kitagawa and Dekker, {Jacqueline M} and Stefan Kiechl and Matthias Sitzer and Horst Bickel and Tatjana Rundek and Albert Hofman and Mathiesen, {Ellisiv B} and Samuela Castelnuovo and Landecho, {Manuel F} and Maria Rosvall and Rafael Gabriel and {de Luca}, Nicola and Jing Liu and Damiano Baldassarre and Maryam Kavousi and {de Groot}, Eric and Bots, {Michiel L} and Yanez, {David N} and Thompson, {Simon G} and {PROG-IMT study group}",
year = "2018",
doi = "10.1371/journal.pone.0191172",
language = "English",
volume = "13",
pages = "e0191172",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

AU - Lorenz, Matthias W

AU - Gao, Lu

AU - Ziegelbauer, Kathrin

AU - Norata, Giuseppe Danilo

AU - Empana, Jean Philippe

AU - Schmidtmann, Irene

AU - Lin, Hung-Ju

AU - McLachlan, Stela

AU - Bokemark, Lena

AU - Ronkainen, Kimmo

AU - Amato, Mauro

AU - Schminke, Ulf

AU - Srinivasan, Sathanur R

AU - Lind, Lars

AU - Okazaki, Shuhei

AU - Stehouwer, Coen D A

AU - Willeit, Peter

AU - Polak, Joseph F

AU - Steinmetz, Helmuth

AU - Sander, Dirk

AU - Poppert, Holger

AU - Desvarieux, Moise

AU - Ikram, M Arfan

AU - Johnsen, Stein Harald

AU - Staub, Daniel

AU - Sirtori, Cesare R

AU - Iglseder, Bernhard

AU - Beloqui, Oscar

AU - Engström, Gunnar

AU - Friera, Alfonso

AU - Rozza, Francesco

AU - Xie, Wuxiang

AU - Parraga, Grace

AU - Grigore, Liliana

AU - Plichart, Matthieu

AU - Blankenberg, Stefan

AU - Su, Ta-Chen

AU - Schmidt, Caroline

AU - Tuomainen, Tomi-Pekka

AU - Veglia, Fabrizio

AU - Völzke, Henry

AU - Nijpels, Giel

AU - Willeit, Johann

AU - Sacco, Ralph L

AU - Franco, Oscar H

AU - Uthoff, Heiko

AU - Hedblad, Bo

AU - Suarez, Carmen

AU - Izzo, Raffaele

AU - Zhao, Dong

AU - Wannarong, Thapat

AU - Catapano, Alberico

AU - Ducimetiere, Pierre

AU - Espinola-Klein, Christine

AU - Chien, Kuo-Liong

AU - Price, Jackie F

AU - Bergström, Göran

AU - Kauhanen, Jussi

AU - Tremoli, Elena

AU - Dörr, Marcus

AU - Berenson, Gerald

AU - Kitagawa, Kazuo

AU - Dekker, Jacqueline M

AU - Kiechl, Stefan

AU - Sitzer, Matthias

AU - Bickel, Horst

AU - Rundek, Tatjana

AU - Hofman, Albert

AU - Mathiesen, Ellisiv B

AU - Castelnuovo, Samuela

AU - Landecho, Manuel F

AU - Rosvall, Maria

AU - Gabriel, Rafael

AU - de Luca, Nicola

AU - Liu, Jing

AU - Baldassarre, Damiano

AU - Kavousi, Maryam

AU - de Groot, Eric

AU - Bots, Michiel L

AU - Yanez, David N

AU - Thompson, Simon G

AU - PROG-IMT study group

PY - 2018

Y1 - 2018

N2 - AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk.METHODS AND RESULTS: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C.CONCLUSIONS: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

AB - AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk.METHODS AND RESULTS: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C.CONCLUSIONS: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

KW - Aged

KW - Cardiovascular Diseases/diagnosis

KW - Carotid Intima-Media Thickness

KW - Female

KW - Humans

KW - Intersectoral Collaboration

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Risk Factors

U2 - 10.1371/journal.pone.0191172

DO - 10.1371/journal.pone.0191172

M3 - SCORING: Journal article

C2 - 29649236

VL - 13

SP - e0191172

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 4

ER -