Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer

Liesa Dziggel; Markus Dahlke; Stefan Janssen; Dagmar Hornung; Oliver Blanck; Mai Trong Khoa; Steven E Schild; Dirk Rades

Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer

Standard

Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer. / Dziggel, Liesa; Dahlke, Markus; Janssen, Stefan; Hornung, Dagmar; Blanck, Oliver; Khoa, Mai Trong; Schild, Steven E; Rades, Dirk.

In: ANTICANCER RES, Vol. 35, No. 12, 12.2015, p. 6793-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dziggel, L, Dahlke, M, Janssen, S, Hornung, D, Blanck, O, Khoa, MT, Schild, SE & Rades, D 2015, 'Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer', ANTICANCER RES, vol. 35, no. 12, pp. 6793-7.

APA

Dziggel, L., Dahlke, M., Janssen, S., Hornung, D., Blanck, O., Khoa, M. T., Schild, S. E., & Rades, D. (2015). Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer. ANTICANCER RES, 35(12), 6793-7.

Vancouver

Dziggel L, Dahlke M, Janssen S, Hornung D, Blanck O, Khoa MT et al. Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer. ANTICANCER RES. 2015 Dec;35(12):6793-7.

Bibtex

@article{047feaac331e489b8a8c6bfe29cf7654,

title = "Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer",

abstract = "AIM: To generate a tool that estimates the probability of developing new cerebral metastases after stereotactic radiosurgery (SRS) in breast cancer patients.PATIENTS AND METHODS: SRS dose plus seven characteristics (age, performance score, number of cerebral metastases, maximum diameter of all metastases, location of metastases, extra-cerebral spread and time from breast cancer diagnosis until SRS) were analyzed regarding their ability to predict the probability of new cerebral metastases development following SRS. For those characteristics deemed significant, points of 0 (higher risk of new lesions) or 1 (lower risk) were given. Scores were generated by adding the points of significant characteristics.RESULTS: Performance score (p=0.013) and maximum diameter of all metastases (p=0.022) were associated with development of subsequent brain metastases. Two groups were created, 0-1 and 2 points. Freedom from new cerebral metastases rates were 27% and 92%, respectively, at 15 months (p=0.003).CONCLUSION: This tool helps select breast cancer with few cerebral metastases receiving SRS who may benefit from additional whole-brain irradiation.",

author = "Liesa Dziggel and Markus Dahlke and Stefan Janssen and Dagmar Hornung and Oliver Blanck and Khoa, {Mai Trong} and Schild, {Steven E} and Dirk Rades",

year = "2015",

month = dec,

language = "English",

volume = "35",

pages = "6793--7",

journal = "ANTICANCER RES",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "12",

}

RIS

TY - JOUR

T1 - Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer

AU - Dziggel, Liesa

AU - Dahlke, Markus

AU - Janssen, Stefan

AU - Hornung, Dagmar

AU - Blanck, Oliver

AU - Khoa, Mai Trong

AU - Schild, Steven E

AU - Rades, Dirk

PY - 2015/12

Y1 - 2015/12

N2 - AIM: To generate a tool that estimates the probability of developing new cerebral metastases after stereotactic radiosurgery (SRS) in breast cancer patients.PATIENTS AND METHODS: SRS dose plus seven characteristics (age, performance score, number of cerebral metastases, maximum diameter of all metastases, location of metastases, extra-cerebral spread and time from breast cancer diagnosis until SRS) were analyzed regarding their ability to predict the probability of new cerebral metastases development following SRS. For those characteristics deemed significant, points of 0 (higher risk of new lesions) or 1 (lower risk) were given. Scores were generated by adding the points of significant characteristics.RESULTS: Performance score (p=0.013) and maximum diameter of all metastases (p=0.022) were associated with development of subsequent brain metastases. Two groups were created, 0-1 and 2 points. Freedom from new cerebral metastases rates were 27% and 92%, respectively, at 15 months (p=0.003).CONCLUSION: This tool helps select breast cancer with few cerebral metastases receiving SRS who may benefit from additional whole-brain irradiation.

AB - AIM: To generate a tool that estimates the probability of developing new cerebral metastases after stereotactic radiosurgery (SRS) in breast cancer patients.PATIENTS AND METHODS: SRS dose plus seven characteristics (age, performance score, number of cerebral metastases, maximum diameter of all metastases, location of metastases, extra-cerebral spread and time from breast cancer diagnosis until SRS) were analyzed regarding their ability to predict the probability of new cerebral metastases development following SRS. For those characteristics deemed significant, points of 0 (higher risk of new lesions) or 1 (lower risk) were given. Scores were generated by adding the points of significant characteristics.RESULTS: Performance score (p=0.013) and maximum diameter of all metastases (p=0.022) were associated with development of subsequent brain metastases. Two groups were created, 0-1 and 2 points. Freedom from new cerebral metastases rates were 27% and 92%, respectively, at 15 months (p=0.003).CONCLUSION: This tool helps select breast cancer with few cerebral metastases receiving SRS who may benefit from additional whole-brain irradiation.

M3 - SCORING: Journal article

C2 - 26637898

VL - 35

SP - 6793

EP - 6797

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 12

ER -