Predicting recurrence of vasovagal syncope: a simple risk score for the clinical routine.
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Predicting recurrence of vasovagal syncope: a simple risk score for the clinical routine. / Aydin, Muhammet Ali; Maas, Renke; Mortensen, Kai; Steinig, Tobias; Klemm, Hanno; Risius, Tim; Meinertz, Thomas; Willems, Stephan; Morillo, Carlos A; Ventura, Rodolfo.
In: J CARDIOVASC ELECTR, Vol. 20, No. 4, 4, 2009, p. 416-421.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Predicting recurrence of vasovagal syncope: a simple risk score for the clinical routine.
AU - Aydin, Muhammet Ali
AU - Maas, Renke
AU - Mortensen, Kai
AU - Steinig, Tobias
AU - Klemm, Hanno
AU - Risius, Tim
AU - Meinertz, Thomas
AU - Willems, Stephan
AU - Morillo, Carlos A
AU - Ventura, Rodolfo
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Predictors for recurrence of syncope are lacking in patients with vasovagal syncope. The aim of this study was to identify risk factors for recurrence of syncope and develop a simple prognostic risk score of clinical value. METHODS: Two hundred seventy-six patients with a history of vasovagal syncope were prospectively followed for 2 years. Diagnosis of vasovagal syncope was based on clinical history and negative standard work-up. Inclusion in the study was independent from the result of the head-up tilt test, which was performed in all cases. Risk factors for syncope recurrence were evaluated by the Cox proportional hazards regression model and implemented in a risk score, which was validated with the log-rank test and an internal cross-validation. RESULTS: The Cox-regression analysis identified the number of previous syncopal events, history of bronchial asthma, and female gender as predictors for syncope recurrence (all P <0.05). In contrast, head-up tilt test response had no predictive value (P = 0.881). Developing a risk score, study patients were identified as having high (recurrence rate during 2 years of follow-up: 37.2%), intermediate (24.8%), and low (6.5%) risk for syncope recurrence (receiver operating characteristic [ROC] of score 0.83, P <0.01; Log-rank test for event-free survival, P <0.005). CONCLUSIONS: In patients with vasovagal syncope, risk of recurrence can be stratified and is predictable based on a simple risk score.
AB - BACKGROUND: Predictors for recurrence of syncope are lacking in patients with vasovagal syncope. The aim of this study was to identify risk factors for recurrence of syncope and develop a simple prognostic risk score of clinical value. METHODS: Two hundred seventy-six patients with a history of vasovagal syncope were prospectively followed for 2 years. Diagnosis of vasovagal syncope was based on clinical history and negative standard work-up. Inclusion in the study was independent from the result of the head-up tilt test, which was performed in all cases. Risk factors for syncope recurrence were evaluated by the Cox proportional hazards regression model and implemented in a risk score, which was validated with the log-rank test and an internal cross-validation. RESULTS: The Cox-regression analysis identified the number of previous syncopal events, history of bronchial asthma, and female gender as predictors for syncope recurrence (all P <0.05). In contrast, head-up tilt test response had no predictive value (P = 0.881). Developing a risk score, study patients were identified as having high (recurrence rate during 2 years of follow-up: 37.2%), intermediate (24.8%), and low (6.5%) risk for syncope recurrence (receiver operating characteristic [ROC] of score 0.83, P <0.01; Log-rank test for event-free survival, P <0.005). CONCLUSIONS: In patients with vasovagal syncope, risk of recurrence can be stratified and is predictable based on a simple risk score.
M3 - SCORING: Zeitschriftenaufsatz
VL - 20
SP - 416
EP - 421
JO - J CARDIOVASC ELECTR
JF - J CARDIOVASC ELECTR
SN - 1045-3873
IS - 4
M1 - 4
ER -
