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Predicting Prognosis of Breast Cancer Patients with Brain Metastases in the BMBC Registry-Comparison of Three Different GPA Prognostic Scores

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Predicting Prognosis of Breast Cancer Patients with Brain Metastases in the BMBC Registry-Comparison of Three Different GPA Prognostic Scores. / Riecke, Kerstin; Müller, Volkmar; Weide, Rudolf; Schmidt, Marcus; Park-Simon, Tjoung-Won; Möbus, Volker; Mundhenke, Christoph; Polasik, Arkadius; Lübbe, Kristina; Hesse, Tobias; Laakmann, Elena; Thill, Marc; A Fasching, Peter; Denkert, Carsten; Fehm, Tanja; Nekljudova, Valentina; Rey, Julia; Loibl, Sibylle; Witzel, Isabell.

In: CANCERS, Vol. 13, No. 4, 844, 17.02.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Riecke, K, Müller, V, Weide, R, Schmidt, M, Park-Simon, T-W, Möbus, V, Mundhenke, C, Polasik, A, Lübbe, K, Hesse, T, Laakmann, E, Thill, M, A Fasching, P, Denkert, C, Fehm, T, Nekljudova, V, Rey, J, Loibl, S & Witzel, I 2021, 'Predicting Prognosis of Breast Cancer Patients with Brain Metastases in the BMBC Registry-Comparison of Three Different GPA Prognostic Scores', CANCERS, vol. 13, no. 4, 844. https://doi.org/10.3390/cancers13040844

APA

Riecke, K., Müller, V., Weide, R., Schmidt, M., Park-Simon, T-W., Möbus, V., Mundhenke, C., Polasik, A., Lübbe, K., Hesse, T., Laakmann, E., Thill, M., A Fasching, P., Denkert, C., Fehm, T., Nekljudova, V., Rey, J., Loibl, S., & Witzel, I. (2021). Predicting Prognosis of Breast Cancer Patients with Brain Metastases in the BMBC Registry-Comparison of Three Different GPA Prognostic Scores. CANCERS, 13(4), [844]. https://doi.org/10.3390/cancers13040844

Vancouver

Riecke K, Müller V, Weide R, Schmidt M, Park-Simon T-W, Möbus V et al. Predicting Prognosis of Breast Cancer Patients with Brain Metastases in the BMBC Registry-Comparison of Three Different GPA Prognostic Scores. CANCERS. 2021 Feb 17;13(4). 844. https://doi.org/10.3390/cancers13040844

Bibtex

@article{3cf795027b284e218f7f835c6ae984e4,
title = "Predicting Prognosis of Breast Cancer Patients with Brain Metastases in the BMBC Registry-Comparison of Three Different GPA Prognostic Scores",
abstract = "Several scores have been developed in order to estimate the prognosis of patients with brain metastases (BM) by objective criteria. The aim of this analysis was to validate all three published graded-prognostic-assessment (GPA)-scores in a subcohort of 882 breast cancer (BC) patients with BM in the Brain Metastases in the German Breast Cancer (BMBC) registry. The median age at diagnosis of BM was 57 years. All in all, 22.3% of patients (n = 197) had triple-negative, 33.4% (n = 295) luminal A like, 25.1% (n = 221) luminal B/HER2-enriched like and 19.2% (n = 169) HER2 positive like BC. Age ≥60 years, evidence of extracranial metastases (ECM), higher number of BM, triple-negative subtype and low Karnofsky-Performance-Status (KPS) were all associated with worse overall survival (OS) in univariate analysis (p < 0.001 each). All three GPA-scores were associated with OS. The breast-GPA showed the highest probability of classifying patients with survival above 12 months in the best prognostic group (specificity 68.7% compared with 48.1% for the updated breast-GPA and 21.8% for the original GPA). Sensitivities for predicting 3 months survival were very low for all scores. In this analysis, all GPA-scores showed only moderate diagnostic accuracy in predicting the OS of BC patients with BM.",
author = "Kerstin Riecke and Volkmar M{\"u}ller and Rudolf Weide and Marcus Schmidt and Tjoung-Won Park-Simon and Volker M{\"o}bus and Christoph Mundhenke and Arkadius Polasik and Kristina L{\"u}bbe and Tobias Hesse and Elena Laakmann and Marc Thill and {A Fasching}, Peter and Carsten Denkert and Tanja Fehm and Valentina Nekljudova and Julia Rey and Sibylle Loibl and Isabell Witzel",
year = "2021",
month = feb,
day = "17",
doi = "10.3390/cancers13040844",
language = "English",
volume = "13",
journal = "CANCERS",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

RIS

TY - JOUR

T1 - Predicting Prognosis of Breast Cancer Patients with Brain Metastases in the BMBC Registry-Comparison of Three Different GPA Prognostic Scores

AU - Riecke, Kerstin

AU - Müller, Volkmar

AU - Weide, Rudolf

AU - Schmidt, Marcus

AU - Park-Simon, Tjoung-Won

AU - Möbus, Volker

AU - Mundhenke, Christoph

AU - Polasik, Arkadius

AU - Lübbe, Kristina

AU - Hesse, Tobias

AU - Laakmann, Elena

AU - Thill, Marc

AU - A Fasching, Peter

AU - Denkert, Carsten

AU - Fehm, Tanja

AU - Nekljudova, Valentina

AU - Rey, Julia

AU - Loibl, Sibylle

AU - Witzel, Isabell

PY - 2021/2/17

Y1 - 2021/2/17

N2 - Several scores have been developed in order to estimate the prognosis of patients with brain metastases (BM) by objective criteria. The aim of this analysis was to validate all three published graded-prognostic-assessment (GPA)-scores in a subcohort of 882 breast cancer (BC) patients with BM in the Brain Metastases in the German Breast Cancer (BMBC) registry. The median age at diagnosis of BM was 57 years. All in all, 22.3% of patients (n = 197) had triple-negative, 33.4% (n = 295) luminal A like, 25.1% (n = 221) luminal B/HER2-enriched like and 19.2% (n = 169) HER2 positive like BC. Age ≥60 years, evidence of extracranial metastases (ECM), higher number of BM, triple-negative subtype and low Karnofsky-Performance-Status (KPS) were all associated with worse overall survival (OS) in univariate analysis (p < 0.001 each). All three GPA-scores were associated with OS. The breast-GPA showed the highest probability of classifying patients with survival above 12 months in the best prognostic group (specificity 68.7% compared with 48.1% for the updated breast-GPA and 21.8% for the original GPA). Sensitivities for predicting 3 months survival were very low for all scores. In this analysis, all GPA-scores showed only moderate diagnostic accuracy in predicting the OS of BC patients with BM.

AB - Several scores have been developed in order to estimate the prognosis of patients with brain metastases (BM) by objective criteria. The aim of this analysis was to validate all three published graded-prognostic-assessment (GPA)-scores in a subcohort of 882 breast cancer (BC) patients with BM in the Brain Metastases in the German Breast Cancer (BMBC) registry. The median age at diagnosis of BM was 57 years. All in all, 22.3% of patients (n = 197) had triple-negative, 33.4% (n = 295) luminal A like, 25.1% (n = 221) luminal B/HER2-enriched like and 19.2% (n = 169) HER2 positive like BC. Age ≥60 years, evidence of extracranial metastases (ECM), higher number of BM, triple-negative subtype and low Karnofsky-Performance-Status (KPS) were all associated with worse overall survival (OS) in univariate analysis (p < 0.001 each). All three GPA-scores were associated with OS. The breast-GPA showed the highest probability of classifying patients with survival above 12 months in the best prognostic group (specificity 68.7% compared with 48.1% for the updated breast-GPA and 21.8% for the original GPA). Sensitivities for predicting 3 months survival were very low for all scores. In this analysis, all GPA-scores showed only moderate diagnostic accuracy in predicting the OS of BC patients with BM.

U2 - 10.3390/cancers13040844

DO - 10.3390/cancers13040844

M3 - SCORING: Journal article

C2 - 33671376

VL - 13

JO - CANCERS

JF - CANCERS

SN - 2072-6694

IS - 4

M1 - 844

ER -