Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescents
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Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescents. / Kühn, Simone; Mascherek, Anna; Banaschewski, Tobias; Bokde, Arun L W; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Millenet, Sabina; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Lindenberger, Ulman; Gallinat, Jürgen.
In: SCI REP-UK, Vol. 10, No. 1, 27.01.2020, p. 1207.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Predicting change trajectories of neuroticism from baseline brain structure using whole brain analyses and latent growth curve models in adolescents
AU - Kühn, Simone
AU - Mascherek, Anna
AU - Banaschewski, Tobias
AU - Bokde, Arun L W
AU - Büchel, Christian
AU - Quinlan, Erin Burke
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Grigis, Antoine
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Martinot, Jean-Luc
AU - Martinot, Marie-Laure Paillère
AU - Nees, Frauke
AU - Orfanos, Dimitri Papadopoulos
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Millenet, Sabina
AU - Fröhner, Juliane H
AU - Smolka, Michael N
AU - Walter, Henrik
AU - Whelan, Robert
AU - Schumann, Gunter
AU - Lindenberger, Ulman
AU - Gallinat, Jürgen
PY - 2020/1/27
Y1 - 2020/1/27
N2 - Adolescence is a vulnerable time for personality development. Especially neuroticism with its link to the development of psychopathology is of interest concerning influential factors. The present study exploratorily investigates neuroanatomical signatures for developmental trajectories of neuroticism based on a voxel-wise whole-brain structural equation modelling framework. In 1,814 healthy adolescents of the IMAGEN sample, the NEO-FFI was acquired at three measurement occasions across five years. Based on a partial measurement invariance second-order latent growth curve model we conducted whole-brain analyses on structural MRI data at age 14 years, predicting change in neuroticism over time. We observed that a reduced volume in the pituitary gland was associated with the slope of neuroticism over time. However, no relations with prefrontal areas emerged. Both findings are discussed against the background of possible genetic and social influences that may account for this result.
AB - Adolescence is a vulnerable time for personality development. Especially neuroticism with its link to the development of psychopathology is of interest concerning influential factors. The present study exploratorily investigates neuroanatomical signatures for developmental trajectories of neuroticism based on a voxel-wise whole-brain structural equation modelling framework. In 1,814 healthy adolescents of the IMAGEN sample, the NEO-FFI was acquired at three measurement occasions across five years. Based on a partial measurement invariance second-order latent growth curve model we conducted whole-brain analyses on structural MRI data at age 14 years, predicting change in neuroticism over time. We observed that a reduced volume in the pituitary gland was associated with the slope of neuroticism over time. However, no relations with prefrontal areas emerged. Both findings are discussed against the background of possible genetic and social influences that may account for this result.
U2 - 10.1038/s41598-020-58128-x
DO - 10.1038/s41598-020-58128-x
M3 - SCORING: Journal article
C2 - 31988389
VL - 10
SP - 1207
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
ER -