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Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling

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Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. / Cheng, Jin; Sahani, Sadhna; Hausrat, Torben Johann; Yang, Jenq-Wei; Ji, Haichao; Schmarowski, Nikolai; Endle, Heiko; Liu, Xinfeng; Li, Yunbo; Böttche, Rahel; Radyushkin, Konstantin; Maric, Hans M; Hoerder-Suabedissen, Anna; Molnár, Zoltán; Prouvot, Pierre-Hugues; Trimbuch, Thorsten; Ninnemann, Olaf; Huai, Jisen; Fan, Wei; Visentin, Barbara; Sabbadini, Roger; Strømgaard, Kristian; Stroh, Albrecht; Luhmann, Heiko J; Kneussel, Matthias; Nitsch, Robert; Vogt, Johannes.

In: NEURON, Vol. 92, No. 1, 05.10.2016, p. 126-142.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Cheng, J, Sahani, S, Hausrat, TJ, Yang, J-W, Ji, H, Schmarowski, N, Endle, H, Liu, X, Li, Y, Böttche, R, Radyushkin, K, Maric, HM, Hoerder-Suabedissen, A, Molnár, Z, Prouvot, P-H, Trimbuch, T, Ninnemann, O, Huai, J, Fan, W, Visentin, B, Sabbadini, R, Strømgaard, K, Stroh, A, Luhmann, HJ, Kneussel, M, Nitsch, R & Vogt, J 2016, 'Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling', NEURON, vol. 92, no. 1, pp. 126-142. https://doi.org/10.1016/j.neuron.2016.08.035

APA

Cheng, J., Sahani, S., Hausrat, T. J., Yang, J-W., Ji, H., Schmarowski, N., Endle, H., Liu, X., Li, Y., Böttche, R., Radyushkin, K., Maric, H. M., Hoerder-Suabedissen, A., Molnár, Z., Prouvot, P-H., Trimbuch, T., Ninnemann, O., Huai, J., Fan, W., ... Vogt, J. (2016). Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. NEURON, 92(1), 126-142. https://doi.org/10.1016/j.neuron.2016.08.035

Vancouver

Cheng J, Sahani S, Hausrat TJ, Yang J-W, Ji H, Schmarowski N et al. Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. NEURON. 2016 Oct 5;92(1):126-142. https://doi.org/10.1016/j.neuron.2016.08.035

Bibtex

@article{0b3bc056cec14f93903a7a5825c4868c,
title = "Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling",
abstract = "Precise connection of thalamic barreloids with their corresponding cortical barrels is critical for processing of vibrissal sensory information. Here, we show that PRG-2, a phospholipid-interacting molecule, is important for thalamocortical axon guidance. Developing thalamocortical fibers both in PRG-2 full knockout (KO) and in thalamus-specific KO mice prematurely entered the cortical plate, eventually innervating non-corresponding barrels. This misrouting relied on lost axonal sensitivity toward lysophosphatidic acid (LPA), which failed to repel PRG-2-deficient thalamocortical fibers. PRG-2 electroporation in the PRG-2(-/-) thalamus restored the aberrant cortical innervation. We identified radixin as a PRG-2 interaction partner and showed that radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG-2. In vivo recordings and whisker-specific behavioral tests demonstrated sensory discrimination deficits in PRG-2(-/-) animals. Our data show that bioactive phospholipids and PRG-2 are critical for guiding thalamic axons to their proper cortical targets.",
author = "Jin Cheng and Sadhna Sahani and Hausrat, {Torben Johann} and Jenq-Wei Yang and Haichao Ji and Nikolai Schmarowski and Heiko Endle and Xinfeng Liu and Yunbo Li and Rahel B{\"o}ttche and Konstantin Radyushkin and Maric, {Hans M} and Anna Hoerder-Suabedissen and Zolt{\'a}n Moln{\'a}r and Pierre-Hugues Prouvot and Thorsten Trimbuch and Olaf Ninnemann and Jisen Huai and Wei Fan and Barbara Visentin and Roger Sabbadini and Kristian Str{\o}mgaard and Albrecht Stroh and Luhmann, {Heiko J} and Matthias Kneussel and Robert Nitsch and Johannes Vogt",
note = "Copyright {\textcopyright} 2016 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = oct,
day = "5",
doi = "10.1016/j.neuron.2016.08.035",
language = "English",
volume = "92",
pages = "126--142",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling

AU - Cheng, Jin

AU - Sahani, Sadhna

AU - Hausrat, Torben Johann

AU - Yang, Jenq-Wei

AU - Ji, Haichao

AU - Schmarowski, Nikolai

AU - Endle, Heiko

AU - Liu, Xinfeng

AU - Li, Yunbo

AU - Böttche, Rahel

AU - Radyushkin, Konstantin

AU - Maric, Hans M

AU - Hoerder-Suabedissen, Anna

AU - Molnár, Zoltán

AU - Prouvot, Pierre-Hugues

AU - Trimbuch, Thorsten

AU - Ninnemann, Olaf

AU - Huai, Jisen

AU - Fan, Wei

AU - Visentin, Barbara

AU - Sabbadini, Roger

AU - Strømgaard, Kristian

AU - Stroh, Albrecht

AU - Luhmann, Heiko J

AU - Kneussel, Matthias

AU - Nitsch, Robert

AU - Vogt, Johannes

N1 - Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2016/10/5

Y1 - 2016/10/5

N2 - Precise connection of thalamic barreloids with their corresponding cortical barrels is critical for processing of vibrissal sensory information. Here, we show that PRG-2, a phospholipid-interacting molecule, is important for thalamocortical axon guidance. Developing thalamocortical fibers both in PRG-2 full knockout (KO) and in thalamus-specific KO mice prematurely entered the cortical plate, eventually innervating non-corresponding barrels. This misrouting relied on lost axonal sensitivity toward lysophosphatidic acid (LPA), which failed to repel PRG-2-deficient thalamocortical fibers. PRG-2 electroporation in the PRG-2(-/-) thalamus restored the aberrant cortical innervation. We identified radixin as a PRG-2 interaction partner and showed that radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG-2. In vivo recordings and whisker-specific behavioral tests demonstrated sensory discrimination deficits in PRG-2(-/-) animals. Our data show that bioactive phospholipids and PRG-2 are critical for guiding thalamic axons to their proper cortical targets.

AB - Precise connection of thalamic barreloids with their corresponding cortical barrels is critical for processing of vibrissal sensory information. Here, we show that PRG-2, a phospholipid-interacting molecule, is important for thalamocortical axon guidance. Developing thalamocortical fibers both in PRG-2 full knockout (KO) and in thalamus-specific KO mice prematurely entered the cortical plate, eventually innervating non-corresponding barrels. This misrouting relied on lost axonal sensitivity toward lysophosphatidic acid (LPA), which failed to repel PRG-2-deficient thalamocortical fibers. PRG-2 electroporation in the PRG-2(-/-) thalamus restored the aberrant cortical innervation. We identified radixin as a PRG-2 interaction partner and showed that radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG-2. In vivo recordings and whisker-specific behavioral tests demonstrated sensory discrimination deficits in PRG-2(-/-) animals. Our data show that bioactive phospholipids and PRG-2 are critical for guiding thalamic axons to their proper cortical targets.

U2 - 10.1016/j.neuron.2016.08.035

DO - 10.1016/j.neuron.2016.08.035

M3 - SCORING: Journal article

C2 - 27641493

VL - 92

SP - 126

EP - 142

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 1

ER -