Prävalenz und Risikofaktoren von Vorhofflimmern in Deutschland: Daten aus der Gutenberg Health Study

TY - JOUR

T1 - Prävalenz und Risikofaktoren von Vorhofflimmern in Deutschland: Daten aus der Gutenberg Health Study

AU - Schnabel, R B

AU - Johannsen, S S

AU - Wild, P S

AU - Blankenberg, S

PY - 2015/2

Y1 - 2015/2

N2 - Atrial fibrillation (AF) is a disease with increasing clinical and public health importance. We describe the prevalence of AF, the current distribution of AF risk factors and their importance in a general population. The distribution of AF risk factors and the medicinal treatment were determined among 10,000 individuals in the population-based Gutenberg Health Study (median age 56 years and 49% women). Individuals with AF (n=309, 3.1%) had a higher median age (67 years) and significantly more risk factors. A large percentage of individuals with AF were taking antithrombotic medication (84% with a CHAD2DS2-VASc score of ≥3). Multiple logistic regression analysis showed that male gender (odds ratio, OR 2.07, 95% CI: 1.59-2.71), age (OR 1.09, 95% CI: 1.07-1.11), body mass index (OR 1.04, 95% CI: 1.02-1.07), prevalent cardiovascular disease (OR 3.06, 95% CI: 2.26-4.11) and heart failure (OR 3.11, 95% CI: 1.92-4.97) were the strongest predictors of AF. The full model explained 18% (Nagelkerke's determination coefficient R(2)) of the variation in AF prevalence. The addition of echocardiographic variables in a subgroup analysis with 5.000 participants increased the explained variation to 23%. AF is a common disease in the general population. Important risk factors for AF, apart from age and male gender, were cardiovascular disease, in particular heart failure, hypertension and increased body mass index. Awareness for AF in the population and medical community needs to be improved.

AB - Atrial fibrillation (AF) is a disease with increasing clinical and public health importance. We describe the prevalence of AF, the current distribution of AF risk factors and their importance in a general population. The distribution of AF risk factors and the medicinal treatment were determined among 10,000 individuals in the population-based Gutenberg Health Study (median age 56 years and 49% women). Individuals with AF (n=309, 3.1%) had a higher median age (67 years) and significantly more risk factors. A large percentage of individuals with AF were taking antithrombotic medication (84% with a CHAD2DS2-VASc score of ≥3). Multiple logistic regression analysis showed that male gender (odds ratio, OR 2.07, 95% CI: 1.59-2.71), age (OR 1.09, 95% CI: 1.07-1.11), body mass index (OR 1.04, 95% CI: 1.02-1.07), prevalent cardiovascular disease (OR 3.06, 95% CI: 2.26-4.11) and heart failure (OR 3.11, 95% CI: 1.92-4.97) were the strongest predictors of AF. The full model explained 18% (Nagelkerke's determination coefficient R(2)) of the variation in AF prevalence. The addition of echocardiographic variables in a subgroup analysis with 5.000 participants increased the explained variation to 23%. AF is a common disease in the general population. Important risk factors for AF, apart from age and male gender, were cardiovascular disease, in particular heart failure, hypertension and increased body mass index. Awareness for AF in the population and medical community needs to be improved.

KW - Adult

KW - Age Distribution

KW - Aged

KW - Atrial Fibrillation/diagnostic imaging

KW - Causality

KW - Comorbidity

KW - Female

KW - Germany/epidemiology

KW - Heart Failure/epidemiology

KW - Humans

KW - Hypertension/epidemiology

KW - Male

KW - Middle Aged

KW - Obesity/epidemiology

KW - Prevalence

KW - Risk Factors

KW - Sex Distribution

KW - Ultrasonography

U2 - 10.1007/s00059-014-4199-6

DO - 10.1007/s00059-014-4199-6

M3 - SCORING: Zeitschriftenaufsatz

C2 - 25604071

VL - 40

SP - 8

EP - 15

JO - HERZ

JF - HERZ

SN - 0340-9937

IS - 1

ER -