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Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin

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Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin. / Stern, Louisa; Boehme, Lukas Fabian; Goetz, Mara Rebecca; Nitschke, Christine; Giannou, Anastasios; Zhang, Tao; Güngör, Cenap; Reeh, Matthias; Izbicki, Jakob Robert; Fliegert, Ralf; Hausen, Anne; Giese, Nathalia; Hackert, Thilo; Niv, Masha Y; Heinrich, Stefan; Gaida, Matthias Martin; Ghadban, Tarik.

In: INT J ONCOL, Vol. 62, No. 1, 6, 01.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stern, L, Boehme, LF, Goetz, MR, Nitschke, C, Giannou, A, Zhang, T, Güngör, C, Reeh, M, Izbicki, JR, Fliegert, R, Hausen, A, Giese, N, Hackert, T, Niv, MY, Heinrich, S, Gaida, MM & Ghadban, T 2023, 'Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin', INT J ONCOL, vol. 62, no. 1, 6. https://doi.org/10.3892/ijo.2022.5454

APA

Stern, L., Boehme, L. F., Goetz, M. R., Nitschke, C., Giannou, A., Zhang, T., Güngör, C., Reeh, M., Izbicki, J. R., Fliegert, R., Hausen, A., Giese, N., Hackert, T., Niv, M. Y., Heinrich, S., Gaida, M. M., & Ghadban, T. (2023). Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin. INT J ONCOL, 62(1), [6]. https://doi.org/10.3892/ijo.2022.5454

Vancouver

Stern L, Boehme LF, Goetz MR, Nitschke C, Giannou A, Zhang T et al. Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin. INT J ONCOL. 2023 Jan;62(1). 6. https://doi.org/10.3892/ijo.2022.5454

Bibtex

@article{64c456e338d0477fadec0ac19ef61113,
title = "Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin",
abstract = "Bitter taste receptors (T2Rs) are G protein‑coupled receptors originally detected in the gustatory system. More recently, T2Rs have been shown to be expressed in extra‑oral cells eliciting non‑gustatory functions. Emerging evidence has suggested a potential role for T2R signaling in diverse pathophysiological conditions, including cancer. -The aim of the present study was to evaluate the expression of T2R14 in pancreatic ductal adenocarcinoma (PDAC) and to assess its involvement in the anticancer effects induced by apigenin, a natural ligand of T2R14. For this purpose, T2R14 expression was explored in PDAC tumor tissue and tumor‑derived cell lines. Using the cell lines expressing the highest levels of T2R14, its effects on chemoresponsiveness and migration upon activation with apigenin were investigated in vitro. To the best of our knowledge, the present study was the first to confirm the expression of the T2R family member T2R14 in PDAC. Patients with relatively high levels of T2R14 expression exhibited significantly prolonged overall survival compared with that of patients with low T2R14 expression. Furthermore, novel functions for apigenin were revealed; notably, apigenin was shown to elicit cytotoxic, anti‑migratory and chemosensitizing effects to 5‑fluoruracil (5‑FU) and to 5‑FU, leucovorin, irinotecan and oxaliplatin in pancreatic cancer cells. In conclusion, the present study extended the evidence for the anticancer effects of apigenin and strongly indicated the functional relevance of T2R14 in PDAC, even though their respective underlying pathways appear to be independent of each other.",
keywords = "Humans, Taste/physiology, Apigenin/pharmacology, Receptors, G-Protein-Coupled/genetics, Signal Transduction, Fluorouracil",
author = "Louisa Stern and Boehme, {Lukas Fabian} and Goetz, {Mara Rebecca} and Christine Nitschke and Anastasios Giannou and Tao Zhang and Cenap G{\"u}ng{\"o}r and Matthias Reeh and Izbicki, {Jakob Robert} and Ralf Fliegert and Anne Hausen and Nathalia Giese and Thilo Hackert and Niv, {Masha Y} and Stefan Heinrich and Gaida, {Matthias Martin} and Tarik Ghadban",
year = "2023",
month = jan,
doi = "10.3892/ijo.2022.5454",
language = "English",
volume = "62",
journal = "INT J ONCOL",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "1",

}

RIS

TY - JOUR

T1 - Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin

AU - Stern, Louisa

AU - Boehme, Lukas Fabian

AU - Goetz, Mara Rebecca

AU - Nitschke, Christine

AU - Giannou, Anastasios

AU - Zhang, Tao

AU - Güngör, Cenap

AU - Reeh, Matthias

AU - Izbicki, Jakob Robert

AU - Fliegert, Ralf

AU - Hausen, Anne

AU - Giese, Nathalia

AU - Hackert, Thilo

AU - Niv, Masha Y

AU - Heinrich, Stefan

AU - Gaida, Matthias Martin

AU - Ghadban, Tarik

PY - 2023/1

Y1 - 2023/1

N2 - Bitter taste receptors (T2Rs) are G protein‑coupled receptors originally detected in the gustatory system. More recently, T2Rs have been shown to be expressed in extra‑oral cells eliciting non‑gustatory functions. Emerging evidence has suggested a potential role for T2R signaling in diverse pathophysiological conditions, including cancer. -The aim of the present study was to evaluate the expression of T2R14 in pancreatic ductal adenocarcinoma (PDAC) and to assess its involvement in the anticancer effects induced by apigenin, a natural ligand of T2R14. For this purpose, T2R14 expression was explored in PDAC tumor tissue and tumor‑derived cell lines. Using the cell lines expressing the highest levels of T2R14, its effects on chemoresponsiveness and migration upon activation with apigenin were investigated in vitro. To the best of our knowledge, the present study was the first to confirm the expression of the T2R family member T2R14 in PDAC. Patients with relatively high levels of T2R14 expression exhibited significantly prolonged overall survival compared with that of patients with low T2R14 expression. Furthermore, novel functions for apigenin were revealed; notably, apigenin was shown to elicit cytotoxic, anti‑migratory and chemosensitizing effects to 5‑fluoruracil (5‑FU) and to 5‑FU, leucovorin, irinotecan and oxaliplatin in pancreatic cancer cells. In conclusion, the present study extended the evidence for the anticancer effects of apigenin and strongly indicated the functional relevance of T2R14 in PDAC, even though their respective underlying pathways appear to be independent of each other.

AB - Bitter taste receptors (T2Rs) are G protein‑coupled receptors originally detected in the gustatory system. More recently, T2Rs have been shown to be expressed in extra‑oral cells eliciting non‑gustatory functions. Emerging evidence has suggested a potential role for T2R signaling in diverse pathophysiological conditions, including cancer. -The aim of the present study was to evaluate the expression of T2R14 in pancreatic ductal adenocarcinoma (PDAC) and to assess its involvement in the anticancer effects induced by apigenin, a natural ligand of T2R14. For this purpose, T2R14 expression was explored in PDAC tumor tissue and tumor‑derived cell lines. Using the cell lines expressing the highest levels of T2R14, its effects on chemoresponsiveness and migration upon activation with apigenin were investigated in vitro. To the best of our knowledge, the present study was the first to confirm the expression of the T2R family member T2R14 in PDAC. Patients with relatively high levels of T2R14 expression exhibited significantly prolonged overall survival compared with that of patients with low T2R14 expression. Furthermore, novel functions for apigenin were revealed; notably, apigenin was shown to elicit cytotoxic, anti‑migratory and chemosensitizing effects to 5‑fluoruracil (5‑FU) and to 5‑FU, leucovorin, irinotecan and oxaliplatin in pancreatic cancer cells. In conclusion, the present study extended the evidence for the anticancer effects of apigenin and strongly indicated the functional relevance of T2R14 in PDAC, even though their respective underlying pathways appear to be independent of each other.

KW - Humans

KW - Taste/physiology

KW - Apigenin/pharmacology

KW - Receptors, G-Protein-Coupled/genetics

KW - Signal Transduction

KW - Fluorouracil

U2 - 10.3892/ijo.2022.5454

DO - 10.3892/ijo.2022.5454

M3 - SCORING: Journal article

C2 - 36382671

VL - 62

JO - INT J ONCOL

JF - INT J ONCOL

SN - 1019-6439

IS - 1

M1 - 6

ER -