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Potential pitfalls in the use of p-values and in interpretation of significance levels.

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Potential pitfalls in the use of p-values and in interpretation of significance levels. / Beck-Bornholdt, Hans-Peter; Dubben, H H.

In: RADIOTHER ONCOL, Vol. 33, No. 2, 2, 1994, p. 171-176.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Beck-Bornholdt, H-P & Dubben, HH 1994, 'Potential pitfalls in the use of p-values and in interpretation of significance levels.', RADIOTHER ONCOL, vol. 33, no. 2, 2, pp. 171-176. <http://www.ncbi.nlm.nih.gov/pubmed/7708961?dopt=Citation>

APA

Beck-Bornholdt, H-P., & Dubben, H. H. (1994). Potential pitfalls in the use of p-values and in interpretation of significance levels. RADIOTHER ONCOL, 33(2), 171-176. [2]. http://www.ncbi.nlm.nih.gov/pubmed/7708961?dopt=Citation

Vancouver

Beck-Bornholdt H-P, Dubben HH. Potential pitfalls in the use of p-values and in interpretation of significance levels. RADIOTHER ONCOL. 1994;33(2):171-176. 2.

Bibtex

@article{de7eb2113b5c40fe9e77786cdcd35b5d,
title = "Potential pitfalls in the use of p-values and in interpretation of significance levels.",
abstract = "In multiparameter analysis of clinical data the likelihood of obtaining significant results, just by chance, increases considerably with the overall number of tests performed. This can be compensated for by adjusting the p-values. Two tables are given from which adjusted p-values may be read off, providing a simple procedure to test the reliability of the results from clinical studies. Multivariate analyses often impress with extremely low p-values, but frequently these results turn out to be non-significant when the influence of multiple testing is considered. As a consequence the actually relevant results might be overlooked, because of the large number of spurious results accumulating in the literature. The use of inappropriate statistics hampers progress in clinical research. It is concluded that more care in the use of p-values in analysis and interpretation of clinical data is required.",
author = "Hans-Peter Beck-Bornholdt and Dubben, {H H}",
year = "1994",
language = "Deutsch",
volume = "33",
pages = "171--176",
journal = "RADIOTHER ONCOL",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Potential pitfalls in the use of p-values and in interpretation of significance levels.

AU - Beck-Bornholdt, Hans-Peter

AU - Dubben, H H

PY - 1994

Y1 - 1994

N2 - In multiparameter analysis of clinical data the likelihood of obtaining significant results, just by chance, increases considerably with the overall number of tests performed. This can be compensated for by adjusting the p-values. Two tables are given from which adjusted p-values may be read off, providing a simple procedure to test the reliability of the results from clinical studies. Multivariate analyses often impress with extremely low p-values, but frequently these results turn out to be non-significant when the influence of multiple testing is considered. As a consequence the actually relevant results might be overlooked, because of the large number of spurious results accumulating in the literature. The use of inappropriate statistics hampers progress in clinical research. It is concluded that more care in the use of p-values in analysis and interpretation of clinical data is required.

AB - In multiparameter analysis of clinical data the likelihood of obtaining significant results, just by chance, increases considerably with the overall number of tests performed. This can be compensated for by adjusting the p-values. Two tables are given from which adjusted p-values may be read off, providing a simple procedure to test the reliability of the results from clinical studies. Multivariate analyses often impress with extremely low p-values, but frequently these results turn out to be non-significant when the influence of multiple testing is considered. As a consequence the actually relevant results might be overlooked, because of the large number of spurious results accumulating in the literature. The use of inappropriate statistics hampers progress in clinical research. It is concluded that more care in the use of p-values in analysis and interpretation of clinical data is required.

M3 - SCORING: Zeitschriftenaufsatz

VL - 33

SP - 171

EP - 176

JO - RADIOTHER ONCOL

JF - RADIOTHER ONCOL

SN - 0167-8140

IS - 2

M1 - 2

ER -