Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.

H Marquardt; Johannes Westendorf; E De Clercq

Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.

Standard

Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes. / Marquardt, H; Westendorf, Johannes; De Clercq, E.

In: CARCINOGENESIS, Vol. 6, No. 8, 8, 1985, p. 1207-1209.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Marquardt, H, Westendorf, J & De Clercq, E 1985, 'Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.', CARCINOGENESIS, vol. 6, no. 8, 8, pp. 1207-1209. <http://www.ncbi.nlm.nih.gov/pubmed/3893787?dopt=Citation>

APA

Marquardt, H., Westendorf, J., & De Clercq, E. (1985). Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes. CARCINOGENESIS, 6(8), 1207-1209. [8]. http://www.ncbi.nlm.nih.gov/pubmed/3893787?dopt=Citation

Vancouver

Marquardt H, Westendorf J, De Clercq E. Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes. CARCINOGENESIS. 1985;6(8):1207-1209. 8.

Bibtex

@article{07370fa138cd42f68f622e6d9b067bfa,

title = "Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.",

abstract = "(E)-5-(2-bromovinyl)-2'-deoxyuridine (BDVU), one of the most potent and selective anti-herpes agents described to date, and its close congeners (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU) and (E)-5-(2-bromovinyl)uracil (BVU), as well as the reference compounds 5-iodo-2'-deoxyuridine (IDU) and 5-trifluoro-2'-deoxythymidine (TFT) were examined for their genotoxic potential. With the exception of a weak activity of TFT in the newly developed strain TA 102, none of the compounds was active in a bacterial cell mutagenesis (Salmonella/microsome) assay. Nor did they induce DNA repair (unscheduled DNA synthesis) in primary rat hepatocytes. In a mammalian cell mutagenesis assay using V79 Chinese hamster cells, the reference compounds IDU and TFT proved highly cytotoxic and mutagenic, whereas BVDU, BVaraU and BVU were neither cytotoxic nor mutagenic.",

author = "H Marquardt and Johannes Westendorf and {De Clercq}, E",

year = "1985",

language = "Deutsch",

volume = "6",

pages = "1207--1209",

journal = "CARCINOGENESIS",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "8",

}

RIS

TY - JOUR

T1 - Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.

AU - Marquardt, H

AU - Westendorf, Johannes

AU - De Clercq, E

PY - 1985

Y1 - 1985

N2 - (E)-5-(2-bromovinyl)-2'-deoxyuridine (BDVU), one of the most potent and selective anti-herpes agents described to date, and its close congeners (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU) and (E)-5-(2-bromovinyl)uracil (BVU), as well as the reference compounds 5-iodo-2'-deoxyuridine (IDU) and 5-trifluoro-2'-deoxythymidine (TFT) were examined for their genotoxic potential. With the exception of a weak activity of TFT in the newly developed strain TA 102, none of the compounds was active in a bacterial cell mutagenesis (Salmonella/microsome) assay. Nor did they induce DNA repair (unscheduled DNA synthesis) in primary rat hepatocytes. In a mammalian cell mutagenesis assay using V79 Chinese hamster cells, the reference compounds IDU and TFT proved highly cytotoxic and mutagenic, whereas BVDU, BVaraU and BVU were neither cytotoxic nor mutagenic.

AB - (E)-5-(2-bromovinyl)-2'-deoxyuridine (BDVU), one of the most potent and selective anti-herpes agents described to date, and its close congeners (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU) and (E)-5-(2-bromovinyl)uracil (BVU), as well as the reference compounds 5-iodo-2'-deoxyuridine (IDU) and 5-trifluoro-2'-deoxythymidine (TFT) were examined for their genotoxic potential. With the exception of a weak activity of TFT in the newly developed strain TA 102, none of the compounds was active in a bacterial cell mutagenesis (Salmonella/microsome) assay. Nor did they induce DNA repair (unscheduled DNA synthesis) in primary rat hepatocytes. In a mammalian cell mutagenesis assay using V79 Chinese hamster cells, the reference compounds IDU and TFT proved highly cytotoxic and mutagenic, whereas BVDU, BVaraU and BVU were neither cytotoxic nor mutagenic.

M3 - SCORING: Zeitschriftenaufsatz

VL - 6

SP - 1207

EP - 1209

JO - CARCINOGENESIS

JF - CARCINOGENESIS

SN - 0143-3334

IS - 8

M1 - 8

ER -