Potent antiviral 2'-fluoro-arabinosyl pyrimidine nucleosides: lack of mutagenic activity.
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Potent antiviral 2'-fluoro-arabinosyl pyrimidine nucleosides: lack of mutagenic activity. / Marquardt, H; Westendorf, Johannes.
In: CARCINOGENESIS, Vol. 3, No. 5, 5, 1982, p. 593-596.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Potent antiviral 2'-fluoro-arabinosyl pyrimidine nucleosides: lack of mutagenic activity.
AU - Marquardt, H
AU - Westendorf, Johannes
PY - 1982
Y1 - 1982
N2 - The carcinogenicity of many drugs, such as antitumor agents, is a subject of growing concern. The newly developed pyrimidine nucleosides, 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine (FIAC) and 2'-fluoro-1-beta-D-arabinofuranosyl-5-methyluracil (FMAU), have shown potent anti-herpes virus activity in tissue cultures, laboratory animals and man and an activity to inhibit the growth of certain tumor cell lines in vitro. Radioactivity of 14C-labeled FIAC and FMAU is incorporated into the DNA of normal and neoplastic mammalian tissues. However, we now report that FIAC and FMAU are inactive in a bacterial mutagenesis assay (Salmonella-microsome test) and in a mammalian cell mutagenesis assay employing V79 Chinese hamster cells in vitro. Both agents did not induce unscheduled DNA synthesis in primary Wistar rat hepatocytes in vitro.
AB - The carcinogenicity of many drugs, such as antitumor agents, is a subject of growing concern. The newly developed pyrimidine nucleosides, 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine (FIAC) and 2'-fluoro-1-beta-D-arabinofuranosyl-5-methyluracil (FMAU), have shown potent anti-herpes virus activity in tissue cultures, laboratory animals and man and an activity to inhibit the growth of certain tumor cell lines in vitro. Radioactivity of 14C-labeled FIAC and FMAU is incorporated into the DNA of normal and neoplastic mammalian tissues. However, we now report that FIAC and FMAU are inactive in a bacterial mutagenesis assay (Salmonella-microsome test) and in a mammalian cell mutagenesis assay employing V79 Chinese hamster cells in vitro. Both agents did not induce unscheduled DNA synthesis in primary Wistar rat hepatocytes in vitro.
M3 - SCORING: Zeitschriftenaufsatz
VL - 3
SP - 593
EP - 596
JO - CARCINOGENESIS
JF - CARCINOGENESIS
SN - 0143-3334
IS - 5
M1 - 5
ER -
