Post-transplant immune reconstitution after unrelated allogeneic stem cell transplant in patients with acute myeloid leukemia.
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Post-transplant immune reconstitution after unrelated allogeneic stem cell transplant in patients with acute myeloid leukemia. / Klyuchnikov, Evgeny; Asenova, Svetlana; Kern, Wolfgang; Kilinc, Gökhan; Ayuketang Ayuk, Francis; Wiedemann, Bettina; Lioznov, Michael; Freiberger, Petra; Zalyalov, Yuriy; Zander, Axel R.; Kröger, Nicolaus; Bacher, Ulrike.
In: LEUKEMIA LYMPHOMA, Vol. 51, No. 8, 8, 2010, p. 1450-1463.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Post-transplant immune reconstitution after unrelated allogeneic stem cell transplant in patients with acute myeloid leukemia.
AU - Klyuchnikov, Evgeny
AU - Asenova, Svetlana
AU - Kern, Wolfgang
AU - Kilinc, Gökhan
AU - Ayuketang Ayuk, Francis
AU - Wiedemann, Bettina
AU - Lioznov, Michael
AU - Freiberger, Petra
AU - Zalyalov, Yuriy
AU - Zander, Axel R.
AU - Kröger, Nicolaus
AU - Bacher, Ulrike
PY - 2010
Y1 - 2010
N2 - We evaluated immune recovery in 67 patients with acute myeloid leukemia (AML) with a median age of 40 years (4-69) following allo-SCT after reduced (n = 35) or myeloablative (n = 32) conditioning. The following lymphocyte populations were determined on days +30, +90, +180, +270, and +365 by flow associated cell sorting: CD3+, CD3+CD4+, CD3+CD8+, CD3+CD4+/CD3+CD8+ ratio, CD3-CD56+, and CD19+ cells. Peripheral blast count >5% was related to lower number of CD3+CD4+ (day +30) and NK cells (day +180; p = 0.02). Intensity of conditioning did not have any significant impact on the kinetics of immune recovery. Patients with normal CD3+CD4+/CD3+CD8+ ratio (day +30) and NK cell count (day +90; p
AB - We evaluated immune recovery in 67 patients with acute myeloid leukemia (AML) with a median age of 40 years (4-69) following allo-SCT after reduced (n = 35) or myeloablative (n = 32) conditioning. The following lymphocyte populations were determined on days +30, +90, +180, +270, and +365 by flow associated cell sorting: CD3+, CD3+CD4+, CD3+CD8+, CD3+CD4+/CD3+CD8+ ratio, CD3-CD56+, and CD19+ cells. Peripheral blast count >5% was related to lower number of CD3+CD4+ (day +30) and NK cells (day +180; p = 0.02). Intensity of conditioning did not have any significant impact on the kinetics of immune recovery. Patients with normal CD3+CD4+/CD3+CD8+ ratio (day +30) and NK cell count (day +90; p
M3 - SCORING: Zeitschriftenaufsatz
VL - 51
SP - 1450
EP - 1463
JO - LEUKEMIA LYMPHOMA
JF - LEUKEMIA LYMPHOMA
SN - 1042-8194
IS - 8
M1 - 8
ER -