Post-transplant immune reconstitution after unrelated allogeneic stem cell transplant in patients with acute myeloid leukemia.

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Post-transplant immune reconstitution after unrelated allogeneic stem cell transplant in patients with acute myeloid leukemia. / Klyuchnikov, Evgeny; Asenova, Svetlana; Kern, Wolfgang; Kilinc, Gökhan; Ayuketang Ayuk, Francis; Wiedemann, Bettina; Lioznov, Michael; Freiberger, Petra; Zalyalov, Yuriy; Zander, Axel R.; Kröger, Nicolaus; Bacher, Ulrike.

In: LEUKEMIA LYMPHOMA, Vol. 51, No. 8, 8, 2010, p. 1450-1463.

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@article{f3990143788e41ff86eccd592ff3eb07,
title = "Post-transplant immune reconstitution after unrelated allogeneic stem cell transplant in patients with acute myeloid leukemia.",
abstract = "We evaluated immune recovery in 67 patients with acute myeloid leukemia (AML) with a median age of 40 years (4-69) following allo-SCT after reduced (n = 35) or myeloablative (n = 32) conditioning. The following lymphocyte populations were determined on days +30, +90, +180, +270, and +365 by flow associated cell sorting: CD3+, CD3+CD4+, CD3+CD8+, CD3+CD4+/CD3+CD8+ ratio, CD3-CD56+, and CD19+ cells. Peripheral blast count >5% was related to lower number of CD3+CD4+ (day +30) and NK cells (day +180; p = 0.02). Intensity of conditioning did not have any significant impact on the kinetics of immune recovery. Patients with normal CD3+CD4+/CD3+CD8+ ratio (day +30) and NK cell count (day +90; p",
author = "Evgeny Klyuchnikov and Svetlana Asenova and Wolfgang Kern and G{\"o}khan Kilinc and {Ayuketang Ayuk}, Francis and Bettina Wiedemann and Michael Lioznov and Petra Freiberger and Yuriy Zalyalov and Zander, {Axel R.} and Nicolaus Kr{\"o}ger and Ulrike Bacher",
year = "2010",
language = "Deutsch",
volume = "51",
pages = "1450--1463",
journal = "LEUKEMIA LYMPHOMA",
issn = "1042-8194",
publisher = "informa healthcare",
number = "8",

}

RIS

TY - JOUR

T1 - Post-transplant immune reconstitution after unrelated allogeneic stem cell transplant in patients with acute myeloid leukemia.

AU - Klyuchnikov, Evgeny

AU - Asenova, Svetlana

AU - Kern, Wolfgang

AU - Kilinc, Gökhan

AU - Ayuketang Ayuk, Francis

AU - Wiedemann, Bettina

AU - Lioznov, Michael

AU - Freiberger, Petra

AU - Zalyalov, Yuriy

AU - Zander, Axel R.

AU - Kröger, Nicolaus

AU - Bacher, Ulrike

PY - 2010

Y1 - 2010

N2 - We evaluated immune recovery in 67 patients with acute myeloid leukemia (AML) with a median age of 40 years (4-69) following allo-SCT after reduced (n = 35) or myeloablative (n = 32) conditioning. The following lymphocyte populations were determined on days +30, +90, +180, +270, and +365 by flow associated cell sorting: CD3+, CD3+CD4+, CD3+CD8+, CD3+CD4+/CD3+CD8+ ratio, CD3-CD56+, and CD19+ cells. Peripheral blast count >5% was related to lower number of CD3+CD4+ (day +30) and NK cells (day +180; p = 0.02). Intensity of conditioning did not have any significant impact on the kinetics of immune recovery. Patients with normal CD3+CD4+/CD3+CD8+ ratio (day +30) and NK cell count (day +90; p

AB - We evaluated immune recovery in 67 patients with acute myeloid leukemia (AML) with a median age of 40 years (4-69) following allo-SCT after reduced (n = 35) or myeloablative (n = 32) conditioning. The following lymphocyte populations were determined on days +30, +90, +180, +270, and +365 by flow associated cell sorting: CD3+, CD3+CD4+, CD3+CD8+, CD3+CD4+/CD3+CD8+ ratio, CD3-CD56+, and CD19+ cells. Peripheral blast count >5% was related to lower number of CD3+CD4+ (day +30) and NK cells (day +180; p = 0.02). Intensity of conditioning did not have any significant impact on the kinetics of immune recovery. Patients with normal CD3+CD4+/CD3+CD8+ ratio (day +30) and NK cell count (day +90; p

M3 - SCORING: Zeitschriftenaufsatz

VL - 51

SP - 1450

EP - 1463

JO - LEUKEMIA LYMPHOMA

JF - LEUKEMIA LYMPHOMA

SN - 1042-8194

IS - 8

M1 - 8

ER -