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Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy

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Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy. / Gröbe, Alexander; Fraederich, Meike; Smeets, Ralf; Heiland, Max; Kluwe, Lan; Zeuch, Jürgen; Haase, Martina; Wikner, Johannes; Hanken, Henning; Semmusch, Jan; Al-Dam, Ahmed; Eichhorn, Wolfgang.

In: BIOMED RES INT , Vol. 2015, 01.01.2015, p. 823651.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gröbe, A, Fraederich, M, Smeets, R, Heiland, M, Kluwe, L, Zeuch, J, Haase, M, Wikner, J, Hanken, H, Semmusch, J, Al-Dam, A & Eichhorn, W 2015, 'Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy', BIOMED RES INT , vol. 2015, pp. 823651. https://doi.org/10.1155/2015/823651

APA

Gröbe, A., Fraederich, M., Smeets, R., Heiland, M., Kluwe, L., Zeuch, J., Haase, M., Wikner, J., Hanken, H., Semmusch, J., Al-Dam, A., & Eichhorn, W. (2015). Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy. BIOMED RES INT , 2015, 823651. https://doi.org/10.1155/2015/823651

Vancouver

Gröbe A, Fraederich M, Smeets R, Heiland M, Kluwe L, Zeuch J et al. Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy. BIOMED RES INT . 2015 Jan 1;2015:823651. https://doi.org/10.1155/2015/823651

Bibtex

@article{a4b272cba9514e4d98b2a3ef77496e5d,
title = "Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy",
abstract = "OBJECT: To determine the incidence of postoperative bleeding for oral osteotomy carried out under continued monoantiplatelet therapy with clopidogrel and dual therapy with clopidogrel/aspirin. Design. Retrospective single center observatory study of two study groups and a control group.METHODS: A total of 64 and 60 oral osteotomy procedures carried out under continued monoclopidogrel therapy and dual clopidogrel/aspirin therapy, respectively, were followed for two weeks for postoperative bleeding. Another 281 similar procedures were also followed as a control group. All oral osteotomy procedures were carried out on an outpatient basis.RESULTS: We observed postoperative bleeding in 2/281 (0.7%) cases in the control group, in 1/64 (1.6%) cases in the clopidogrel group, and in 2/60 (3.3%) cases in the dual clopidogrel/aspirin group. The corresponding 95% confidence intervals are 0-1.7%, 0-4.7%, and 0-7.8%, respectively, and the incidences did not differ significantly among the three groups (P > 0.09). Postoperative hemorrhage was treated successfully in all cases with local measures. No changes of antiplatelet medication, transfusion, nor hospitalisation were necessary. No major cardiovascular events were recorded.CONCLUSIONS: Our results indicate that minor oral surgery can be performed safely under continued monoantiplatelet medication with clopidogrel or dual antiplatelet medication with clopidogrel/aspirin.",
author = "Alexander Gr{\"o}be and Meike Fraederich and Ralf Smeets and Max Heiland and Lan Kluwe and J{\"u}rgen Zeuch and Martina Haase and Johannes Wikner and Henning Hanken and Jan Semmusch and Ahmed Al-Dam and Wolfgang Eichhorn",
year = "2015",
month = jan,
day = "1",
doi = "10.1155/2015/823651",
language = "English",
volume = "2015",
pages = "823651",
journal = "BIOMED RES INT ",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Postoperative bleeding risk for oral surgery under continued clopidogrel antiplatelet therapy

AU - Gröbe, Alexander

AU - Fraederich, Meike

AU - Smeets, Ralf

AU - Heiland, Max

AU - Kluwe, Lan

AU - Zeuch, Jürgen

AU - Haase, Martina

AU - Wikner, Johannes

AU - Hanken, Henning

AU - Semmusch, Jan

AU - Al-Dam, Ahmed

AU - Eichhorn, Wolfgang

PY - 2015/1/1

Y1 - 2015/1/1

N2 - OBJECT: To determine the incidence of postoperative bleeding for oral osteotomy carried out under continued monoantiplatelet therapy with clopidogrel and dual therapy with clopidogrel/aspirin. Design. Retrospective single center observatory study of two study groups and a control group.METHODS: A total of 64 and 60 oral osteotomy procedures carried out under continued monoclopidogrel therapy and dual clopidogrel/aspirin therapy, respectively, were followed for two weeks for postoperative bleeding. Another 281 similar procedures were also followed as a control group. All oral osteotomy procedures were carried out on an outpatient basis.RESULTS: We observed postoperative bleeding in 2/281 (0.7%) cases in the control group, in 1/64 (1.6%) cases in the clopidogrel group, and in 2/60 (3.3%) cases in the dual clopidogrel/aspirin group. The corresponding 95% confidence intervals are 0-1.7%, 0-4.7%, and 0-7.8%, respectively, and the incidences did not differ significantly among the three groups (P > 0.09). Postoperative hemorrhage was treated successfully in all cases with local measures. No changes of antiplatelet medication, transfusion, nor hospitalisation were necessary. No major cardiovascular events were recorded.CONCLUSIONS: Our results indicate that minor oral surgery can be performed safely under continued monoantiplatelet medication with clopidogrel or dual antiplatelet medication with clopidogrel/aspirin.

AB - OBJECT: To determine the incidence of postoperative bleeding for oral osteotomy carried out under continued monoantiplatelet therapy with clopidogrel and dual therapy with clopidogrel/aspirin. Design. Retrospective single center observatory study of two study groups and a control group.METHODS: A total of 64 and 60 oral osteotomy procedures carried out under continued monoclopidogrel therapy and dual clopidogrel/aspirin therapy, respectively, were followed for two weeks for postoperative bleeding. Another 281 similar procedures were also followed as a control group. All oral osteotomy procedures were carried out on an outpatient basis.RESULTS: We observed postoperative bleeding in 2/281 (0.7%) cases in the control group, in 1/64 (1.6%) cases in the clopidogrel group, and in 2/60 (3.3%) cases in the dual clopidogrel/aspirin group. The corresponding 95% confidence intervals are 0-1.7%, 0-4.7%, and 0-7.8%, respectively, and the incidences did not differ significantly among the three groups (P > 0.09). Postoperative hemorrhage was treated successfully in all cases with local measures. No changes of antiplatelet medication, transfusion, nor hospitalisation were necessary. No major cardiovascular events were recorded.CONCLUSIONS: Our results indicate that minor oral surgery can be performed safely under continued monoantiplatelet medication with clopidogrel or dual antiplatelet medication with clopidogrel/aspirin.

U2 - 10.1155/2015/823651

DO - 10.1155/2015/823651

M3 - SCORING: Journal article

C2 - 25632402

VL - 2015

SP - 823651

JO - BIOMED RES INT

JF - BIOMED RES INT

SN - 2314-6133

ER -