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Postmortem 31P magnetic resonance spectroscopy of the skeletal muscle: α-ATP/Pi ratio as a forensic tool?

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Postmortem 31P magnetic resonance spectroscopy of the skeletal muscle: α-ATP/Pi ratio as a forensic tool? / Schmidt, Tony M; Wang, Zhiyue J; Keller, Sarah; Heinemann, Axel; Acar, Suzan; Graessner, Joachim; Schoennagel, Bjoern P; Adam, Gerhard; Fischer, Roland; Yamamura, Jin.

In: FORENSIC SCI INT, Vol. 242, 01.09.2014, p. 172-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schmidt, TM, Wang, ZJ, Keller, S, Heinemann, A, Acar, S, Graessner, J, Schoennagel, BP, Adam, G, Fischer, R & Yamamura, J 2014, 'Postmortem 31P magnetic resonance spectroscopy of the skeletal muscle: α-ATP/Pi ratio as a forensic tool?', FORENSIC SCI INT, vol. 242, pp. 172-6. https://doi.org/10.1016/j.forsciint.2014.06.009

APA

Schmidt, T. M., Wang, Z. J., Keller, S., Heinemann, A., Acar, S., Graessner, J., Schoennagel, B. P., Adam, G., Fischer, R., & Yamamura, J. (2014). Postmortem 31P magnetic resonance spectroscopy of the skeletal muscle: α-ATP/Pi ratio as a forensic tool? FORENSIC SCI INT, 242, 172-6. https://doi.org/10.1016/j.forsciint.2014.06.009

Vancouver

Schmidt TM, Wang ZJ, Keller S, Heinemann A, Acar S, Graessner J et al. Postmortem 31P magnetic resonance spectroscopy of the skeletal muscle: α-ATP/Pi ratio as a forensic tool? FORENSIC SCI INT. 2014 Sep 1;242:172-6. https://doi.org/10.1016/j.forsciint.2014.06.009

Bibtex

@article{b410d885800545d2b3a9e9f4010a8408,
title = "Postmortem 31P magnetic resonance spectroscopy of the skeletal muscle: α-ATP/Pi ratio as a forensic tool?",
abstract = "PURPOSE: Phosphor magnetic resonance spectroscopy ((31)P MRS) is an established method for metabolic examinations of resting and exercising skeletal muscle. So far, there are few MRS investigations of human corpses. The aim of this study was to investigate the temporal postmortem pattern of phosphor metabolites in the adductor magnus muscle and to check the value of MRS as a forensic tool, especially for the determination of the time of death.MATERIAL AND METHODS: Eight corpses, died of natural cause, were examined (5 males, 3 females; age: 73±7 y, weight 65.8±15.9 kg). A control group of 3 subjects (2 males, 1 female, mean age: 51±24 y, range: 24-69 y, mean body weight: 84.0±16.5 kg) was examined at a single time point as well. (31)P MRS was performed on a 1.5 T MRI (TR 700 ms, TE 0.35 ms, averages 256, flip angle 90°). A standard (31)P/(1)H heart/liver coil was employed (receiver coil diameter 12 cm). The (31)P MRS scans were repeated in intervals of 1 h over a period from 4.5 to 24 h postmortem (p.m.). The core temperature was rectally measured throughout the MRI examination.RESULTS: The mean core temperature decreased from 36.0°C to 25.7°C. In vivo and ex vivo spectra showed characteristic differences, especially the PCr metabolite was no longer detectable after 10 h p.m. The α-ATP/Pi ratio decreased with time from 0.445 to 0.032 over 24 h p.m.CONCLUSION: There is a characteristic postmortem time pattern of the phosphor metabolites. Especially the acquired α-ATP/Pi ratio could be described by a significant exponential time course (r(2)=0.92, p<0.001). (31)P MRS might be added to the postmortem imaging methods.",
author = "Schmidt, {Tony M} and Wang, {Zhiyue J} and Sarah Keller and Axel Heinemann and Suzan Acar and Joachim Graessner and Schoennagel, {Bjoern P} and Gerhard Adam and Roland Fischer and Jin Yamamura",
note = "Copyright {\textcopyright} 2014 Elsevier Ireland Ltd. All rights reserved.",
year = "2014",
month = sep,
day = "1",
doi = "10.1016/j.forsciint.2014.06.009",
language = "English",
volume = "242",
pages = "172--6",
journal = "FORENSIC SCI INT",
issn = "0379-0738",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Postmortem 31P magnetic resonance spectroscopy of the skeletal muscle: α-ATP/Pi ratio as a forensic tool?

AU - Schmidt, Tony M

AU - Wang, Zhiyue J

AU - Keller, Sarah

AU - Heinemann, Axel

AU - Acar, Suzan

AU - Graessner, Joachim

AU - Schoennagel, Bjoern P

AU - Adam, Gerhard

AU - Fischer, Roland

AU - Yamamura, Jin

N1 - Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - PURPOSE: Phosphor magnetic resonance spectroscopy ((31)P MRS) is an established method for metabolic examinations of resting and exercising skeletal muscle. So far, there are few MRS investigations of human corpses. The aim of this study was to investigate the temporal postmortem pattern of phosphor metabolites in the adductor magnus muscle and to check the value of MRS as a forensic tool, especially for the determination of the time of death.MATERIAL AND METHODS: Eight corpses, died of natural cause, were examined (5 males, 3 females; age: 73±7 y, weight 65.8±15.9 kg). A control group of 3 subjects (2 males, 1 female, mean age: 51±24 y, range: 24-69 y, mean body weight: 84.0±16.5 kg) was examined at a single time point as well. (31)P MRS was performed on a 1.5 T MRI (TR 700 ms, TE 0.35 ms, averages 256, flip angle 90°). A standard (31)P/(1)H heart/liver coil was employed (receiver coil diameter 12 cm). The (31)P MRS scans were repeated in intervals of 1 h over a period from 4.5 to 24 h postmortem (p.m.). The core temperature was rectally measured throughout the MRI examination.RESULTS: The mean core temperature decreased from 36.0°C to 25.7°C. In vivo and ex vivo spectra showed characteristic differences, especially the PCr metabolite was no longer detectable after 10 h p.m. The α-ATP/Pi ratio decreased with time from 0.445 to 0.032 over 24 h p.m.CONCLUSION: There is a characteristic postmortem time pattern of the phosphor metabolites. Especially the acquired α-ATP/Pi ratio could be described by a significant exponential time course (r(2)=0.92, p<0.001). (31)P MRS might be added to the postmortem imaging methods.

AB - PURPOSE: Phosphor magnetic resonance spectroscopy ((31)P MRS) is an established method for metabolic examinations of resting and exercising skeletal muscle. So far, there are few MRS investigations of human corpses. The aim of this study was to investigate the temporal postmortem pattern of phosphor metabolites in the adductor magnus muscle and to check the value of MRS as a forensic tool, especially for the determination of the time of death.MATERIAL AND METHODS: Eight corpses, died of natural cause, were examined (5 males, 3 females; age: 73±7 y, weight 65.8±15.9 kg). A control group of 3 subjects (2 males, 1 female, mean age: 51±24 y, range: 24-69 y, mean body weight: 84.0±16.5 kg) was examined at a single time point as well. (31)P MRS was performed on a 1.5 T MRI (TR 700 ms, TE 0.35 ms, averages 256, flip angle 90°). A standard (31)P/(1)H heart/liver coil was employed (receiver coil diameter 12 cm). The (31)P MRS scans were repeated in intervals of 1 h over a period from 4.5 to 24 h postmortem (p.m.). The core temperature was rectally measured throughout the MRI examination.RESULTS: The mean core temperature decreased from 36.0°C to 25.7°C. In vivo and ex vivo spectra showed characteristic differences, especially the PCr metabolite was no longer detectable after 10 h p.m. The α-ATP/Pi ratio decreased with time from 0.445 to 0.032 over 24 h p.m.CONCLUSION: There is a characteristic postmortem time pattern of the phosphor metabolites. Especially the acquired α-ATP/Pi ratio could be described by a significant exponential time course (r(2)=0.92, p<0.001). (31)P MRS might be added to the postmortem imaging methods.

U2 - 10.1016/j.forsciint.2014.06.009

DO - 10.1016/j.forsciint.2014.06.009

M3 - SCORING: Journal article

C2 - 25062532

VL - 242

SP - 172

EP - 176

JO - FORENSIC SCI INT

JF - FORENSIC SCI INT

SN - 0379-0738

ER -