Posterior reversible encephalopathy syndrome
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Posterior reversible encephalopathy syndrome. / Fischer, Marlene; Schmutzhard, Erich.
In: J NEUROL, Vol. 264, No. 8, 08.2017, p. 1608-1616.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Posterior reversible encephalopathy syndrome
AU - Fischer, Marlene
AU - Schmutzhard, Erich
PY - 2017/8
Y1 - 2017/8
N2 - The posterior reversible encephalopathy syndrome (PRES) is a neurological disorder of (sub)acute onset characterized by varied neurological symptoms, which may include headache, impaired visual acuity or visual field deficits, disorders of consciousness, confusion, seizures, and focal neurological deficits. In a majority of patients the clinical presentation includes elevated arterial blood pressure up to hypertensive emergencies. Neuroimaging, in particular magnetic resonance imaging, frequently shows a distinctive parieto-occipital pattern with a symmetric distribution of changes reflecting vasogenic edema. PRES frequently develops in the context of cytotoxic medication, (pre)eclampsia, sepsis, renal disease or autoimmune disorders. The treatment is symptomatic and is determined by the underlying condition. The overall prognosis is favorable, since clinical symptoms as well as imaging lesions are reversible in most patients. However, neurological sequelae including long-term epilepsy may persist in individual cases.
AB - The posterior reversible encephalopathy syndrome (PRES) is a neurological disorder of (sub)acute onset characterized by varied neurological symptoms, which may include headache, impaired visual acuity or visual field deficits, disorders of consciousness, confusion, seizures, and focal neurological deficits. In a majority of patients the clinical presentation includes elevated arterial blood pressure up to hypertensive emergencies. Neuroimaging, in particular magnetic resonance imaging, frequently shows a distinctive parieto-occipital pattern with a symmetric distribution of changes reflecting vasogenic edema. PRES frequently develops in the context of cytotoxic medication, (pre)eclampsia, sepsis, renal disease or autoimmune disorders. The treatment is symptomatic and is determined by the underlying condition. The overall prognosis is favorable, since clinical symptoms as well as imaging lesions are reversible in most patients. However, neurological sequelae including long-term epilepsy may persist in individual cases.
U2 - 10.1007/s00415-016-8377-8
DO - 10.1007/s00415-016-8377-8
M3 - SCORING: Review article
C2 - 28054130
VL - 264
SP - 1608
EP - 1616
JO - J NEUROL
JF - J NEUROL
SN - 0340-5354
IS - 8
ER -