Population-based and controlled study to evaluate neuroblastoma screening at one year of age in Germany: interim results.
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Population-based and controlled study to evaluate neuroblastoma screening at one year of age in Germany: interim results. / Schilling, F H; Berthold, F; Erttmann, Rudolf; Michaelis, J; Spix, C; Sander, J; Schwarz, K; Treuner, J.
In: Med Pediatr Oncol, Vol. 35, No. 6, 6, 2000, p. 701-704.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Population-based and controlled study to evaluate neuroblastoma screening at one year of age in Germany: interim results.
AU - Schilling, F H
AU - Berthold, F
AU - Erttmann, Rudolf
AU - Michaelis, J
AU - Spix, C
AU - Sander, J
AU - Schwarz, K
AU - Treuner, J
PY - 2000
Y1 - 2000
N2 - BACKGROUND: The German Neuroblastoma Screening Project is the first controlled and population-based screening study to evaluate the presumed benefit of neuroblastoma mass screening at 1 year of age (10-18 months). PROCEDURE: Screening takes place in 6 of the 16 German states; children from the remainder serve as controls. The German Childhood Cancer Registry enables a mostly complete follow-up and detection of false-negative patients. RESULTS: Up to December, 1999, 1,199,165 children were examined for urinary catecholamine metabolites and 124 cases of neuroblastoma were detected preclinically, giving a detection rate of 10.3/100,000. Within this cohort, 33 false-negative cases were found. CONCLUSIONS: The results of this screening program will be crucial for further implementation of neuroblastoma screening.
AB - BACKGROUND: The German Neuroblastoma Screening Project is the first controlled and population-based screening study to evaluate the presumed benefit of neuroblastoma mass screening at 1 year of age (10-18 months). PROCEDURE: Screening takes place in 6 of the 16 German states; children from the remainder serve as controls. The German Childhood Cancer Registry enables a mostly complete follow-up and detection of false-negative patients. RESULTS: Up to December, 1999, 1,199,165 children were examined for urinary catecholamine metabolites and 124 cases of neuroblastoma were detected preclinically, giving a detection rate of 10.3/100,000. Within this cohort, 33 false-negative cases were found. CONCLUSIONS: The results of this screening program will be crucial for further implementation of neuroblastoma screening.
M3 - SCORING: Zeitschriftenaufsatz
VL - 35
SP - 701
EP - 704
IS - 6
M1 - 6
ER -