Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period
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Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period. / Schaumburg, Frieder; Köck, Robin; Mellmann, Alexander; Richter, Laura; Hasenberg, Felicitas; Kriegeskorte, André; Friedrich, Alexander W; Gatermann, Sören; Peters, Georg; von Eiff, Christof; Becker, Karsten; Study Group.
In: J CLIN MICROBIOL, Vol. 50, No. 10, 10.2012, p. 3186-92.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period
AU - Schaumburg, Frieder
AU - Köck, Robin
AU - Mellmann, Alexander
AU - Richter, Laura
AU - Hasenberg, Felicitas
AU - Kriegeskorte, André
AU - Friedrich, Alexander W
AU - Gatermann, Sören
AU - Peters, Georg
AU - von Eiff, Christof
AU - Becker, Karsten
AU - Study Group
PY - 2012/10
Y1 - 2012/10
N2 - Methicillin-resistant Staphylococcus aureus (MRSA) originated from the health care setting but is now emerging in communities without health care contact (CA-MRSA) or in livestock (LA-MRSA). The impact on the whole MRSA population was assessed in a German prospective multicenter study. Thirty-three laboratories consecutively collected up to 50 MRSA isolates from infection or carriage during two sampling periods in 2004 to 2005 and 2010 to 2011. Patient-related data were collected using a standardized questionnaire. Methicillin resistance was confirmed by the detection of mecA or its homologue mecA(LGA251). The spa type and major virulence factors were analyzed for each isolate. In total, 1,604 (2004 to 2005) and 1,603 (2010 to 2011) MRSA isolates were analyzed; one isolate from each sampling period harbored mecA(LGA251). LA-MRSA increased significantly (odds ratio [OR] = 22.67, 95% confidence interval [CI] = 8.51 to 85.49, P < 0.0005) and spread over Germany, originating from northwestern regions. Panton-Valentine leukocidin-positive CA-MRSA rose significantly, particularly in southern Germany, but the proportion in 2010 to 2011 remained low (2.7%, OR = 2.80, 95% CI = 1.54 to 5.34, P < 0.0005). The emerging MRSA clones changed the MRSA population in Germany during a 6-year period significantly. The ongoing epidemiological shift and changes of MRSA sources create a need for revision of guidelines for MRSA infection control and treatment.
AB - Methicillin-resistant Staphylococcus aureus (MRSA) originated from the health care setting but is now emerging in communities without health care contact (CA-MRSA) or in livestock (LA-MRSA). The impact on the whole MRSA population was assessed in a German prospective multicenter study. Thirty-three laboratories consecutively collected up to 50 MRSA isolates from infection or carriage during two sampling periods in 2004 to 2005 and 2010 to 2011. Patient-related data were collected using a standardized questionnaire. Methicillin resistance was confirmed by the detection of mecA or its homologue mecA(LGA251). The spa type and major virulence factors were analyzed for each isolate. In total, 1,604 (2004 to 2005) and 1,603 (2010 to 2011) MRSA isolates were analyzed; one isolate from each sampling period harbored mecA(LGA251). LA-MRSA increased significantly (odds ratio [OR] = 22.67, 95% confidence interval [CI] = 8.51 to 85.49, P < 0.0005) and spread over Germany, originating from northwestern regions. Panton-Valentine leukocidin-positive CA-MRSA rose significantly, particularly in southern Germany, but the proportion in 2010 to 2011 remained low (2.7%, OR = 2.80, 95% CI = 1.54 to 5.34, P < 0.0005). The emerging MRSA clones changed the MRSA population in Germany during a 6-year period significantly. The ongoing epidemiological shift and changes of MRSA sources create a need for revision of guidelines for MRSA infection control and treatment.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Bacterial Proteins
KW - Bacterial Toxins
KW - Carrier State
KW - Exotoxins
KW - Female
KW - Genetic Variation
KW - Genotype
KW - Germany
KW - Humans
KW - Leukocidins
KW - Male
KW - Methicillin-Resistant Staphylococcus aureus
KW - Middle Aged
KW - Molecular Epidemiology
KW - Molecular Typing
KW - Penicillin-Binding Proteins
KW - Prospective Studies
KW - Staphylococcal Infections
KW - Staphylococcal Protein A
KW - Journal Article
KW - Multicenter Study
KW - Research Support, Non-U.S. Gov't
U2 - 10.1128/JCM.01174-12
DO - 10.1128/JCM.01174-12
M3 - SCORING: Journal article
C2 - 22814464
VL - 50
SP - 3186
EP - 3192
JO - J CLIN MICROBIOL
JF - J CLIN MICROBIOL
SN - 0095-1137
IS - 10
ER -