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Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest

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Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest. / Dyshlovoy, Sergey A; Tarbeeva, Darya; Fedoreyev, Sergey; Busenbender, Tobias; Kaune, Moritz; Veselova, Marina; Kalinovskiy, Anatoliy; Hauschild, Jessica; Grigorchuk, Valeria; Kim, Natalya; Bokemeyer, Carsten; Graefen, Markus; Gorovoy, Petr; von Amsberg, Gunhild.

In: BIOMOLECULES, Vol. 10, No. 3, 14.03.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dyshlovoy, SA, Tarbeeva, D, Fedoreyev, S, Busenbender, T, Kaune, M, Veselova, M, Kalinovskiy, A, Hauschild, J, Grigorchuk, V, Kim, N, Bokemeyer, C, Graefen, M, Gorovoy, P & von Amsberg, G 2020, 'Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest', BIOMOLECULES, vol. 10, no. 3. https://doi.org/10.3390/biom10030451

APA

Dyshlovoy, S. A., Tarbeeva, D., Fedoreyev, S., Busenbender, T., Kaune, M., Veselova, M., Kalinovskiy, A., Hauschild, J., Grigorchuk, V., Kim, N., Bokemeyer, C., Graefen, M., Gorovoy, P., & von Amsberg, G. (2020). Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest. BIOMOLECULES, 10(3). https://doi.org/10.3390/biom10030451

Vancouver

Dyshlovoy SA, Tarbeeva D, Fedoreyev S, Busenbender T, Kaune M, Veselova M et al. Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest. BIOMOLECULES. 2020 Mar 14;10(3). https://doi.org/10.3390/biom10030451

Bibtex

@article{a64c730d3e034122b33571ffc0062996,
title = "Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest",
abstract = "From a root bark of Lespedeza bicolor Turch we isolated two new (7 and 8) and six previously known compounds (1-6) belonging to the group of prenylated polyphenols. Their structures were elucidated using mass spectrometry, nuclear magnetic resonance and circular dichroism spectroscopy. These natural compounds selectively inhibited human drug-resistant prostate cancer in vitro. Prenylated pterocarpans 1-3 prevented the cell cycle progression of human cancer cells in S-phase. This was accompanied by a reduced expression of mRNA corresponding to several human cyclin-dependent kinases (CDKs). In contrast, compounds 4-8 induced a G1-phase cell cycle arrest without any pronounced effect on CDKs mRNA expression. Interestingly, a non-substituted hydroxy group at C-8 of ring D of the pterocarpan skeleton of compounds 1-3 seems to be important for the CDKs inhibitory activity.",
author = "Dyshlovoy, {Sergey A} and Darya Tarbeeva and Sergey Fedoreyev and Tobias Busenbender and Moritz Kaune and Marina Veselova and Anatoliy Kalinovskiy and Jessica Hauschild and Valeria Grigorchuk and Natalya Kim and Carsten Bokemeyer and Markus Graefen and Petr Gorovoy and {von Amsberg}, Gunhild",
year = "2020",
month = mar,
day = "14",
doi = "10.3390/biom10030451",
language = "English",
volume = "10",
journal = "BIOMOLECULES",
issn = "2218-273X",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "3",

}

RIS

TY - JOUR

T1 - Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest

AU - Dyshlovoy, Sergey A

AU - Tarbeeva, Darya

AU - Fedoreyev, Sergey

AU - Busenbender, Tobias

AU - Kaune, Moritz

AU - Veselova, Marina

AU - Kalinovskiy, Anatoliy

AU - Hauschild, Jessica

AU - Grigorchuk, Valeria

AU - Kim, Natalya

AU - Bokemeyer, Carsten

AU - Graefen, Markus

AU - Gorovoy, Petr

AU - von Amsberg, Gunhild

PY - 2020/3/14

Y1 - 2020/3/14

N2 - From a root bark of Lespedeza bicolor Turch we isolated two new (7 and 8) and six previously known compounds (1-6) belonging to the group of prenylated polyphenols. Their structures were elucidated using mass spectrometry, nuclear magnetic resonance and circular dichroism spectroscopy. These natural compounds selectively inhibited human drug-resistant prostate cancer in vitro. Prenylated pterocarpans 1-3 prevented the cell cycle progression of human cancer cells in S-phase. This was accompanied by a reduced expression of mRNA corresponding to several human cyclin-dependent kinases (CDKs). In contrast, compounds 4-8 induced a G1-phase cell cycle arrest without any pronounced effect on CDKs mRNA expression. Interestingly, a non-substituted hydroxy group at C-8 of ring D of the pterocarpan skeleton of compounds 1-3 seems to be important for the CDKs inhibitory activity.

AB - From a root bark of Lespedeza bicolor Turch we isolated two new (7 and 8) and six previously known compounds (1-6) belonging to the group of prenylated polyphenols. Their structures were elucidated using mass spectrometry, nuclear magnetic resonance and circular dichroism spectroscopy. These natural compounds selectively inhibited human drug-resistant prostate cancer in vitro. Prenylated pterocarpans 1-3 prevented the cell cycle progression of human cancer cells in S-phase. This was accompanied by a reduced expression of mRNA corresponding to several human cyclin-dependent kinases (CDKs). In contrast, compounds 4-8 induced a G1-phase cell cycle arrest without any pronounced effect on CDKs mRNA expression. Interestingly, a non-substituted hydroxy group at C-8 of ring D of the pterocarpan skeleton of compounds 1-3 seems to be important for the CDKs inhibitory activity.

U2 - 10.3390/biom10030451

DO - 10.3390/biom10030451

M3 - SCORING: Journal article

C2 - 32183314

VL - 10

JO - BIOMOLECULES

JF - BIOMOLECULES

SN - 2218-273X

IS - 3

ER -