Polymorphous light eruption (PLE) and a new potent antioxidant and UVA-protective formulation as prophylaxis.
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Polymorphous light eruption (PLE) and a new potent antioxidant and UVA-protective formulation as prophylaxis. / Hadshiew, I M; Treder-Conrad, C; V Bülow, R; Klette, E; Mann, T; Stäb, F; Moll, Ingrid; Rippke, F.
In: PHOTODERMATOL PHOTO, Vol. 20, No. 4, 4, 2004, p. 200-204.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Polymorphous light eruption (PLE) and a new potent antioxidant and UVA-protective formulation as prophylaxis.
AU - Hadshiew, I M
AU - Treder-Conrad, C
AU - V Bülow, R
AU - Klette, E
AU - Mann, T
AU - Stäb, F
AU - Moll, Ingrid
AU - Rippke, F
PY - 2004
Y1 - 2004
N2 - BACKGROUND: Polymorphous light eruption (PLE) is the most common photodermatosis. While its etiology still remains elusive, pathogenesis seems to involve UVA-induced oxidative stress and subsequent deregulation of antioxidative immune responses. Only few and often ineffective prophylactic and therapeutic measures exist to date. METHODS: In our randomized, double-blind, placebo-controlled clinical study, we compared the efficacy of a new topical formulation, consisting of 0.25%alpha-glucosylrutin (AGR) (a natural, modified flavonoid), 1% tocopheryl acetate (vitamin E) and a broad-spectrum, highly UVA-protective sunscreen (SPF 15) in a hydrodispersion gel vehicle, to a sunscreen-only gel and vehicle. Thirty patients with a history of PLE were pretreated with either the above formulation, a similar preparation (with the same concentration for vitamin E and AGR, but a different UV filter system), placebo or a SPF 15 sunscreen-only gel, 30 min prior to daily photoprovocation with UVA irradiations of 60-100 J/cm(2) to 5 x 5 cm(2) areas on the upper arms. RESULTS: After 4 days, results revealed a statistically highly significant difference (P
AB - BACKGROUND: Polymorphous light eruption (PLE) is the most common photodermatosis. While its etiology still remains elusive, pathogenesis seems to involve UVA-induced oxidative stress and subsequent deregulation of antioxidative immune responses. Only few and often ineffective prophylactic and therapeutic measures exist to date. METHODS: In our randomized, double-blind, placebo-controlled clinical study, we compared the efficacy of a new topical formulation, consisting of 0.25%alpha-glucosylrutin (AGR) (a natural, modified flavonoid), 1% tocopheryl acetate (vitamin E) and a broad-spectrum, highly UVA-protective sunscreen (SPF 15) in a hydrodispersion gel vehicle, to a sunscreen-only gel and vehicle. Thirty patients with a history of PLE were pretreated with either the above formulation, a similar preparation (with the same concentration for vitamin E and AGR, but a different UV filter system), placebo or a SPF 15 sunscreen-only gel, 30 min prior to daily photoprovocation with UVA irradiations of 60-100 J/cm(2) to 5 x 5 cm(2) areas on the upper arms. RESULTS: After 4 days, results revealed a statistically highly significant difference (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 20
SP - 200
EP - 204
JO - PHOTODERMATOL PHOTO
JF - PHOTODERMATOL PHOTO
SN - 0905-4383
IS - 4
M1 - 4
ER -