Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function

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Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function. / Giegling, Ina; Hartmann, Annette M; Genius, Just; Konte, Bettina; Maul, Stephan; Straube, Andreas; Eggert, Thomas; Mulert, Christoph; Leicht, Gregor; Karch, Susanne; Hegerl, Ulrich; Pogarell, Oliver; Hölter, Sabine M; Möller, Hans-Jürgen; Graw, Jochen; Rujescu, Dan.

In: TRANSL PSYCHIAT, Vol. 10, No. 1, 21.04.2020, p. 113.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

Harvard

Giegling, I, Hartmann, AM, Genius, J, Konte, B, Maul, S, Straube, A, Eggert, T, Mulert, C, Leicht, G, Karch, S, Hegerl, U, Pogarell, O, Hölter, SM, Möller, H-J, Graw, J & Rujescu, D 2020, 'Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function', TRANSL PSYCHIAT, vol. 10, no. 1, pp. 113. https://doi.org/10.1038/s41398-020-0791-0

APA

Giegling, I., Hartmann, A. M., Genius, J., Konte, B., Maul, S., Straube, A., Eggert, T., Mulert, C., Leicht, G., Karch, S., Hegerl, U., Pogarell, O., Hölter, S. M., Möller, H-J., Graw, J., & Rujescu, D. (2020). Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function. TRANSL PSYCHIAT, 10(1), 113. https://doi.org/10.1038/s41398-020-0791-0

Vancouver

Bibtex

@article{c095f05e8f0e4e2da0f442d9dce3fd33,
title = "Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function",
abstract = "βB2-crystallin (gene symbol: Crybb2/CRYBB2) was first described as a structural protein of the ocular lens before it was detected in various brain regions of the mouse, including the hippocampus and the cerebral cortex. Mutations in the mouse Crybb2 gene lead to alterations of sensorimotor gating measured as prepulse inhibition (PPI) and reduced hippocampal size, combined with an altered number of parvalbumin-positive GABAergic interneurons. Decreased PPI and alterations of parvalbumin-positive interneurons are also endophenotypes that typically occur in schizophrenia. To verify the results found in mice, we genotyped 27 single nucleotide polymorphisms (SNPs) within the CRYBB2 gene and its flanking regions and investigated different schizophrenia typical endophenotypes in a sample of 510 schizophrenia patients and 1322 healthy controls. In the case-control study, no association with schizophrenia was found. However, 3 of the 4 investigated haplotype blocks indicated a decreased CRYBB2 mRNA expression. Two of these blocks were associated with poorer antisaccade task performance and altered working memory-linked functional magnetic resonance imaging signals. For the two haplotypes associated with antisaccade performance, suggestive evidence was found with visual memory and in addition, haplotype block 4 showed a nominally significant association with reduced sensorimotor gating, measured as P50 ratio. These results were not schizophrenia-specific, but could be detected in a combined sample of patients and healthy controls. This is the first study to demonstrate the importance of βB2-crystallin for antisaccade performance and memory function in humans and therefore provides implications for βB2-crystallin function in the human brain.verifiziert von Sarah",
author = "Ina Giegling and Hartmann, {Annette M} and Just Genius and Bettina Konte and Stephan Maul and Andreas Straube and Thomas Eggert and Christoph Mulert and Gregor Leicht and Susanne Karch and Ulrich Hegerl and Oliver Pogarell and H{\"o}lter, {Sabine M} and Hans-J{\"u}rgen M{\"o}ller and Jochen Graw and Dan Rujescu",
year = "2020",
month = apr,
day = "21",
doi = "10.1038/s41398-020-0791-0",
language = "English",
volume = "10",
pages = "113",
journal = "TRANSL PSYCHIAT",
issn = "2158-3188",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function

AU - Giegling, Ina

AU - Hartmann, Annette M

AU - Genius, Just

AU - Konte, Bettina

AU - Maul, Stephan

AU - Straube, Andreas

AU - Eggert, Thomas

AU - Mulert, Christoph

AU - Leicht, Gregor

AU - Karch, Susanne

AU - Hegerl, Ulrich

AU - Pogarell, Oliver

AU - Hölter, Sabine M

AU - Möller, Hans-Jürgen

AU - Graw, Jochen

AU - Rujescu, Dan

PY - 2020/4/21

Y1 - 2020/4/21

N2 - βB2-crystallin (gene symbol: Crybb2/CRYBB2) was first described as a structural protein of the ocular lens before it was detected in various brain regions of the mouse, including the hippocampus and the cerebral cortex. Mutations in the mouse Crybb2 gene lead to alterations of sensorimotor gating measured as prepulse inhibition (PPI) and reduced hippocampal size, combined with an altered number of parvalbumin-positive GABAergic interneurons. Decreased PPI and alterations of parvalbumin-positive interneurons are also endophenotypes that typically occur in schizophrenia. To verify the results found in mice, we genotyped 27 single nucleotide polymorphisms (SNPs) within the CRYBB2 gene and its flanking regions and investigated different schizophrenia typical endophenotypes in a sample of 510 schizophrenia patients and 1322 healthy controls. In the case-control study, no association with schizophrenia was found. However, 3 of the 4 investigated haplotype blocks indicated a decreased CRYBB2 mRNA expression. Two of these blocks were associated with poorer antisaccade task performance and altered working memory-linked functional magnetic resonance imaging signals. For the two haplotypes associated with antisaccade performance, suggestive evidence was found with visual memory and in addition, haplotype block 4 showed a nominally significant association with reduced sensorimotor gating, measured as P50 ratio. These results were not schizophrenia-specific, but could be detected in a combined sample of patients and healthy controls. This is the first study to demonstrate the importance of βB2-crystallin for antisaccade performance and memory function in humans and therefore provides implications for βB2-crystallin function in the human brain.verifiziert von Sarah

AB - βB2-crystallin (gene symbol: Crybb2/CRYBB2) was first described as a structural protein of the ocular lens before it was detected in various brain regions of the mouse, including the hippocampus and the cerebral cortex. Mutations in the mouse Crybb2 gene lead to alterations of sensorimotor gating measured as prepulse inhibition (PPI) and reduced hippocampal size, combined with an altered number of parvalbumin-positive GABAergic interneurons. Decreased PPI and alterations of parvalbumin-positive interneurons are also endophenotypes that typically occur in schizophrenia. To verify the results found in mice, we genotyped 27 single nucleotide polymorphisms (SNPs) within the CRYBB2 gene and its flanking regions and investigated different schizophrenia typical endophenotypes in a sample of 510 schizophrenia patients and 1322 healthy controls. In the case-control study, no association with schizophrenia was found. However, 3 of the 4 investigated haplotype blocks indicated a decreased CRYBB2 mRNA expression. Two of these blocks were associated with poorer antisaccade task performance and altered working memory-linked functional magnetic resonance imaging signals. For the two haplotypes associated with antisaccade performance, suggestive evidence was found with visual memory and in addition, haplotype block 4 showed a nominally significant association with reduced sensorimotor gating, measured as P50 ratio. These results were not schizophrenia-specific, but could be detected in a combined sample of patients and healthy controls. This is the first study to demonstrate the importance of βB2-crystallin for antisaccade performance and memory function in humans and therefore provides implications for βB2-crystallin function in the human brain.verifiziert von Sarah

U2 - 10.1038/s41398-020-0791-0

DO - 10.1038/s41398-020-0791-0

M3 - SCORING: Journal article

C2 - 32317624

VL - 10

SP - 113

JO - TRANSL PSYCHIAT

JF - TRANSL PSYCHIAT

SN - 2158-3188

IS - 1

ER -