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Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents

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Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents. / Lancaster, Thomas M; Linden, David E; Tansey, Katherine E; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Artiges, Eric; Lemaitre, Herve; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Smolka, Michael N; Vetter, Nora C; Jurk, Sarah; Mennigen, Eva; Walter, Henrik; Whelan, Robert; Schumann, Gunter; IMAGEN Consortium.

In: JAMA PSYCHIAT, Vol. 73, No. 8, 01.08.2016, p. 852-61.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lancaster, TM, Linden, DE, Tansey, KE, Banaschewski, T, Bokde, ALW, Bromberg, U, Büchel, C, Cattrell, A, Conrod, PJ, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Paillère Martinot, M-L, Artiges, E, Lemaitre, H, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Smolka, MN, Vetter, NC, Jurk, S, Mennigen, E, Walter, H, Whelan, R, Schumann, G & IMAGEN Consortium 2016, 'Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents', JAMA PSYCHIAT, vol. 73, no. 8, pp. 852-61. https://doi.org/10.1001/jamapsychiatry.2016.1135

APA

Lancaster, T. M., Linden, D. E., Tansey, K. E., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J-L., Paillère Martinot, M-L., Artiges, E., ... IMAGEN Consortium (2016). Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents. JAMA PSYCHIAT, 73(8), 852-61. https://doi.org/10.1001/jamapsychiatry.2016.1135

Vancouver

Lancaster TM, Linden DE, Tansey KE, Banaschewski T, Bokde ALW, Bromberg U et al. Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents. JAMA PSYCHIAT. 2016 Aug 1;73(8):852-61. https://doi.org/10.1001/jamapsychiatry.2016.1135

Bibtex

@article{136b1853e19142669c5b9de9453ad7a6,
title = "Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents",
abstract = "IMPORTANCE: Psychotic disorders are characterized by attenuated activity in the brain's valuation system in key reward processing areas, such as the ventral striatum (VS), as measured with functional magnetic resonance imaging.OBJECTIVE: To examine whether common risk variants for psychosis are associated with individual variation in the VS.DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional study of a large cohort of adolescents from the IMAGEN study (a European multicenter study of reinforcement sensitivity in adolescents) was performed from March 1, 2008, through December 31, 2011. Data analysis was conducted from October 1, 2015, to January 9, 2016. Polygenic risk profile scores (RPSs) for psychosis were generated for 1841 healthy adolescents. Sample size and characteristics varied across regression analyses, depending on mutual information available (N = 1524-1836).MAIN OUTCOMES AND MEASURES: Reward-related brain function was assessed with blood oxygen level dependency (BOLD) in the VS using the monetary incentive delay (MID) task, distinguishing reward anticipation and receipt. Behavioral impulsivity, IQ, MID task performance, and VS BOLD were regressed against psychosis RPS at 4 progressive P thresholds (P < .01, P < .05, P < .10, and P < .50 for RPS models 1-4, respectively).RESULTS: In a sample of 1841 healthy adolescents (mean age, 14.5 years; 906 boys and 935 girls), we replicated an association between increasing psychosis RPS and reduced IQ (matrix reasoning: corrected P = .003 for RPS model 2, 0.4% variance explained), supporting the validity of the psychosis RPS models. We also found a nominally significant association between increased psychosis RPS and reduced MID task performance (uncorrected P = .03 for RPS model 4, 0.2% variance explained). Our main finding was a positive association between psychosis RPS and VS BOLD during reward anticipation at all 4 psychosis RPS models and for 2 P thresholds for reward receipt (RPS models 1 and 3), correcting for the familywise error rate (0.8%-1.9% variance explained).CONCLUSIONS AND RELEVANCE: These findings support an association between psychosis RPS and VS BOLD in adolescents. Genetic risk for psychosis may shape an individual's response to rewarding stimuli.",
author = "Lancaster, {Thomas M} and Linden, {David E} and Tansey, {Katherine E} and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Anna Cattrell and Conrod, {Patricia J} and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and {Paill{\`e}re Martinot}, Marie-Laure and Eric Artiges and Herve Lemaitre and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Smolka, {Michael N} and Vetter, {Nora C} and Sarah Jurk and Eva Mennigen and Henrik Walter and Robert Whelan and Gunter Schumann and {IMAGEN Consortium}",
year = "2016",
month = aug,
day = "1",
doi = "10.1001/jamapsychiatry.2016.1135",
language = "English",
volume = "73",
pages = "852--61",
journal = "JAMA PSYCHIAT",
issn = "2168-622X",
publisher = "American Medical Association",
number = "8",

}

RIS

TY - JOUR

T1 - Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents

AU - Lancaster, Thomas M

AU - Linden, David E

AU - Tansey, Katherine E

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia J

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Paillère Martinot, Marie-Laure

AU - Artiges, Eric

AU - Lemaitre, Herve

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Smolka, Michael N

AU - Vetter, Nora C

AU - Jurk, Sarah

AU - Mennigen, Eva

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - IMAGEN Consortium

PY - 2016/8/1

Y1 - 2016/8/1

N2 - IMPORTANCE: Psychotic disorders are characterized by attenuated activity in the brain's valuation system in key reward processing areas, such as the ventral striatum (VS), as measured with functional magnetic resonance imaging.OBJECTIVE: To examine whether common risk variants for psychosis are associated with individual variation in the VS.DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional study of a large cohort of adolescents from the IMAGEN study (a European multicenter study of reinforcement sensitivity in adolescents) was performed from March 1, 2008, through December 31, 2011. Data analysis was conducted from October 1, 2015, to January 9, 2016. Polygenic risk profile scores (RPSs) for psychosis were generated for 1841 healthy adolescents. Sample size and characteristics varied across regression analyses, depending on mutual information available (N = 1524-1836).MAIN OUTCOMES AND MEASURES: Reward-related brain function was assessed with blood oxygen level dependency (BOLD) in the VS using the monetary incentive delay (MID) task, distinguishing reward anticipation and receipt. Behavioral impulsivity, IQ, MID task performance, and VS BOLD were regressed against psychosis RPS at 4 progressive P thresholds (P < .01, P < .05, P < .10, and P < .50 for RPS models 1-4, respectively).RESULTS: In a sample of 1841 healthy adolescents (mean age, 14.5 years; 906 boys and 935 girls), we replicated an association between increasing psychosis RPS and reduced IQ (matrix reasoning: corrected P = .003 for RPS model 2, 0.4% variance explained), supporting the validity of the psychosis RPS models. We also found a nominally significant association between increased psychosis RPS and reduced MID task performance (uncorrected P = .03 for RPS model 4, 0.2% variance explained). Our main finding was a positive association between psychosis RPS and VS BOLD during reward anticipation at all 4 psychosis RPS models and for 2 P thresholds for reward receipt (RPS models 1 and 3), correcting for the familywise error rate (0.8%-1.9% variance explained).CONCLUSIONS AND RELEVANCE: These findings support an association between psychosis RPS and VS BOLD in adolescents. Genetic risk for psychosis may shape an individual's response to rewarding stimuli.

AB - IMPORTANCE: Psychotic disorders are characterized by attenuated activity in the brain's valuation system in key reward processing areas, such as the ventral striatum (VS), as measured with functional magnetic resonance imaging.OBJECTIVE: To examine whether common risk variants for psychosis are associated with individual variation in the VS.DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional study of a large cohort of adolescents from the IMAGEN study (a European multicenter study of reinforcement sensitivity in adolescents) was performed from March 1, 2008, through December 31, 2011. Data analysis was conducted from October 1, 2015, to January 9, 2016. Polygenic risk profile scores (RPSs) for psychosis were generated for 1841 healthy adolescents. Sample size and characteristics varied across regression analyses, depending on mutual information available (N = 1524-1836).MAIN OUTCOMES AND MEASURES: Reward-related brain function was assessed with blood oxygen level dependency (BOLD) in the VS using the monetary incentive delay (MID) task, distinguishing reward anticipation and receipt. Behavioral impulsivity, IQ, MID task performance, and VS BOLD were regressed against psychosis RPS at 4 progressive P thresholds (P < .01, P < .05, P < .10, and P < .50 for RPS models 1-4, respectively).RESULTS: In a sample of 1841 healthy adolescents (mean age, 14.5 years; 906 boys and 935 girls), we replicated an association between increasing psychosis RPS and reduced IQ (matrix reasoning: corrected P = .003 for RPS model 2, 0.4% variance explained), supporting the validity of the psychosis RPS models. We also found a nominally significant association between increased psychosis RPS and reduced MID task performance (uncorrected P = .03 for RPS model 4, 0.2% variance explained). Our main finding was a positive association between psychosis RPS and VS BOLD during reward anticipation at all 4 psychosis RPS models and for 2 P thresholds for reward receipt (RPS models 1 and 3), correcting for the familywise error rate (0.8%-1.9% variance explained).CONCLUSIONS AND RELEVANCE: These findings support an association between psychosis RPS and VS BOLD in adolescents. Genetic risk for psychosis may shape an individual's response to rewarding stimuli.

U2 - 10.1001/jamapsychiatry.2016.1135

DO - 10.1001/jamapsychiatry.2016.1135

M3 - SCORING: Journal article

C2 - 27384424

VL - 73

SP - 852

EP - 861

JO - JAMA PSYCHIAT

JF - JAMA PSYCHIAT

SN - 2168-622X

IS - 8

ER -