Research ExplorerPublicationsPoly(ethylene carbonate) as a surface-eroding biomaterial fo...

Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: a feasibility study

Standard

Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: a feasibility study. / Liu, Yu; Kemmer, Annette; Keim, Klaus; Curdy, Catherine; Petersen, Holger; Kissel, Thomas.

In: EUR J PHARM BIOPHARM, Vol. 76, No. 2, 10.2010, p. 222-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Liu, Y, Kemmer, A, Keim, K, Curdy, C, Petersen, H & Kissel, T 2010, 'Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: a feasibility study', EUR J PHARM BIOPHARM, vol. 76, no. 2, pp. 222-9. https://doi.org/10.1016/j.ejpb.2010.07.009

APA

Liu, Y., Kemmer, A., Keim, K., Curdy, C., Petersen, H., & Kissel, T. (2010). Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: a feasibility study. EUR J PHARM BIOPHARM, 76(2), 222-9. https://doi.org/10.1016/j.ejpb.2010.07.009

Vancouver

Liu Y, Kemmer A, Keim K, Curdy C, Petersen H, Kissel T. Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: a feasibility study. EUR J PHARM BIOPHARM. 2010 Oct;76(2):222-9. https://doi.org/10.1016/j.ejpb.2010.07.009

Bibtex

@article{5cf8b453a8e949c7b675d8f167b4e7a6,
title = "Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: a feasibility study",
abstract = "To evaluate the technical feasibility of poly(ethylene carbonate), PEC, for injectable in situ forming drug delivery systems, the physical properties of PEC solutions were characterized. The solubility of PEC was investigated in different solvents, and the Hildebrand solubility parameters and Flory-Huggins interaction parameters of PEC were determined. By turbidity titration, the experimental ternary phase diagram of water-NMP/DMSO-PEC was constructed. NMP solution required more water to precipitate PEC compared to DMSO solution. The dynamic viscosity of PEC solution increased at lower temperature, higher polymer concentration and longer aging time. Differential scanning calorimetric (DSC) measurements confirmed only weak physical interactions in the system after aging, and the physical aging effect was thermo-reversible. Release of NMP from PEC formulations was twofold slower than that of DMSO at similar concentrations. The morphology of PEC depots after injection into aqueous solution was studied using scanning electron microscopy (SEM). A DMSO formulation of bovine serum albumin displayed less burst release than a NMP formulation. In summary, our investigations demonstrate that in situ depot forming systems can be obtained from PEC solutions. Moreover, a solution of PEC in DMSO would be preferred over NMP due to the reduced burst release.",
keywords = "Animals, Calorimetry, Differential Scanning, Cattle, Delayed-Action Preparations, Dimethyl Sulfoxide, Drug Delivery Systems, Drug Storage, Feasibility Studies, Microscopy, Electron, Scanning, Microspheres, Polyethylenes, Pyrrolidinones, Serum Albumin, Bovine, Solubility, Solvents, Temperature, Time Factors, Viscosity, Comparative Study, Journal Article",
author = "Yu Liu and Annette Kemmer and Klaus Keim and Catherine Curdy and Holger Petersen and Thomas Kissel",
note = "Copyright {\textcopyright} 2010 Elsevier B.V. All rights reserved.",
year = "2010",
month = oct,
doi = "10.1016/j.ejpb.2010.07.009",
language = "English",
volume = "76",
pages = "222--9",
journal = "EUR J PHARM BIOPHARM",
issn = "0939-6411",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Poly(ethylene carbonate) as a surface-eroding biomaterial for in situ forming parenteral drug delivery systems: a feasibility study

AU - Liu, Yu

AU - Kemmer, Annette

AU - Keim, Klaus

AU - Curdy, Catherine

AU - Petersen, Holger

AU - Kissel, Thomas

N1 - Copyright © 2010 Elsevier B.V. All rights reserved.

PY - 2010/10

Y1 - 2010/10

N2 - To evaluate the technical feasibility of poly(ethylene carbonate), PEC, for injectable in situ forming drug delivery systems, the physical properties of PEC solutions were characterized. The solubility of PEC was investigated in different solvents, and the Hildebrand solubility parameters and Flory-Huggins interaction parameters of PEC were determined. By turbidity titration, the experimental ternary phase diagram of water-NMP/DMSO-PEC was constructed. NMP solution required more water to precipitate PEC compared to DMSO solution. The dynamic viscosity of PEC solution increased at lower temperature, higher polymer concentration and longer aging time. Differential scanning calorimetric (DSC) measurements confirmed only weak physical interactions in the system after aging, and the physical aging effect was thermo-reversible. Release of NMP from PEC formulations was twofold slower than that of DMSO at similar concentrations. The morphology of PEC depots after injection into aqueous solution was studied using scanning electron microscopy (SEM). A DMSO formulation of bovine serum albumin displayed less burst release than a NMP formulation. In summary, our investigations demonstrate that in situ depot forming systems can be obtained from PEC solutions. Moreover, a solution of PEC in DMSO would be preferred over NMP due to the reduced burst release.

AB - To evaluate the technical feasibility of poly(ethylene carbonate), PEC, for injectable in situ forming drug delivery systems, the physical properties of PEC solutions were characterized. The solubility of PEC was investigated in different solvents, and the Hildebrand solubility parameters and Flory-Huggins interaction parameters of PEC were determined. By turbidity titration, the experimental ternary phase diagram of water-NMP/DMSO-PEC was constructed. NMP solution required more water to precipitate PEC compared to DMSO solution. The dynamic viscosity of PEC solution increased at lower temperature, higher polymer concentration and longer aging time. Differential scanning calorimetric (DSC) measurements confirmed only weak physical interactions in the system after aging, and the physical aging effect was thermo-reversible. Release of NMP from PEC formulations was twofold slower than that of DMSO at similar concentrations. The morphology of PEC depots after injection into aqueous solution was studied using scanning electron microscopy (SEM). A DMSO formulation of bovine serum albumin displayed less burst release than a NMP formulation. In summary, our investigations demonstrate that in situ depot forming systems can be obtained from PEC solutions. Moreover, a solution of PEC in DMSO would be preferred over NMP due to the reduced burst release.

KW - Animals

KW - Calorimetry, Differential Scanning

KW - Cattle

KW - Delayed-Action Preparations

KW - Dimethyl Sulfoxide

KW - Drug Delivery Systems

KW - Drug Storage

KW - Feasibility Studies

KW - Microscopy, Electron, Scanning

KW - Microspheres

KW - Polyethylenes

KW - Pyrrolidinones

KW - Serum Albumin, Bovine

KW - Solubility

KW - Solvents

KW - Temperature

KW - Time Factors

KW - Viscosity

KW - Comparative Study

KW - Journal Article

U2 - 10.1016/j.ejpb.2010.07.009

DO - 10.1016/j.ejpb.2010.07.009

M3 - SCORING: Journal article

C2 - 20650316

VL - 76

SP - 222

EP - 229

JO - EUR J PHARM BIOPHARM

JF - EUR J PHARM BIOPHARM

SN - 0939-6411

IS - 2

ER -