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Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women

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Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women. / De Jong, Kirstie A; Berisha, Filip; Naderpoor, Negar; Appelbe, Alan; Kotowicz, Mark A; Cukier, Kimberly; McGee, Sean L; Nikolaev, Viacheslav O.

In: PLOS ONE, Vol. 17, No. 2, e0263312, 2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

De Jong, KA, Berisha, F, Naderpoor, N, Appelbe, A, Kotowicz, MA, Cukier, K, McGee, SL & Nikolaev, VO 2022, 'Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women', PLOS ONE, vol. 17, no. 2, e0263312. https://doi.org/10.1371/journal.pone.0263312

APA

De Jong, K. A., Berisha, F., Naderpoor, N., Appelbe, A., Kotowicz, M. A., Cukier, K., McGee, S. L., & Nikolaev, V. O. (2022). Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women. PLOS ONE, 17(2), [e0263312]. https://doi.org/10.1371/journal.pone.0263312

Vancouver

De Jong KA, Berisha F, Naderpoor N, Appelbe A, Kotowicz MA, Cukier K et al. Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women. PLOS ONE. 2022;17(2). e0263312. https://doi.org/10.1371/journal.pone.0263312

Bibtex

@article{0e2abdee2631473ba127170d2c869ff7,
title = "Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women",
abstract = "BACKGROUND: It remains unclear as to whether polycystic ovary syndrome (PCOS) is an additional risk factor in the development of left ventricular (LV) hypertrophy in obese women. In the current study, we provide clarity on this issue by rigorously analysing patient LV geometry beyond the basic clinical measures currently used. Importantly, the cohort contained only normotensive patients that would normally be deemed low risk with no further intervention required.METHODS: The study comprised 24 obese women with PCOS and 29 obese Control women. Transthoracic echocardiography was used to evaluate LV structure/function. Basic clinical and metabolic data were collected for each participant consisting of age, BMI, blood pressure, fasting glucose, LDL-C, HLD-C, cholesterol and triglyceride levels. Exclusion criteria; BMI < 30 g/m2, type 2 diabetes, hypertension.RESULTS: Both groups exhibited concentric remodelling of the LV posterior wall at a prevalence of ~20%, this associated with grade 1 diastolic dysfunction. Estimated LV mass/height2.7 was increased patients with PCOS (45 ± 2.2 vs 37 ± 1.6) with 33% exhibiting LV mass/height2.7 above ASE guidelines, compared to 7% in Controls. Furthermore, 25% of patients with PCOS were characterised with concentric hypertrophy, an alteration in LV geometry that was not observed in the Control group.CONCLUSIONS: To our knowledge, this is the first study to assess LV geometric patterns in obese women with PCOS. The results suggest that obese women with PCOS are at greater risk of concentric hypertrophy than obese only women and provide justification for additional cardiovascular risk assessment in normotensive obese/PCOS women.",
keywords = "Adult, Blood Glucose, Blood Pressure, Cholesterol/blood, Cholesterol, HDL/blood, Cholesterol, LDL/blood, Echocardiography, Female, Heart Failure, Diastolic/complications, Heart Ventricles/diagnostic imaging, Humans, Hypertrophy, Left Ventricular/blood, Obesity/blood, Polycystic Ovary Syndrome/blood, Triglycerides/blood, Ventricular Function, Left/physiology",
author = "{De Jong}, {Kirstie A} and Filip Berisha and Negar Naderpoor and Alan Appelbe and Kotowicz, {Mark A} and Kimberly Cukier and McGee, {Sean L} and Nikolaev, {Viacheslav O}",
year = "2022",
doi = "10.1371/journal.pone.0263312",
language = "English",
volume = "17",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Polycystic ovarian syndrome increases prevalence of concentric hypertrophy in normotensive obese women

AU - De Jong, Kirstie A

AU - Berisha, Filip

AU - Naderpoor, Negar

AU - Appelbe, Alan

AU - Kotowicz, Mark A

AU - Cukier, Kimberly

AU - McGee, Sean L

AU - Nikolaev, Viacheslav O

PY - 2022

Y1 - 2022

N2 - BACKGROUND: It remains unclear as to whether polycystic ovary syndrome (PCOS) is an additional risk factor in the development of left ventricular (LV) hypertrophy in obese women. In the current study, we provide clarity on this issue by rigorously analysing patient LV geometry beyond the basic clinical measures currently used. Importantly, the cohort contained only normotensive patients that would normally be deemed low risk with no further intervention required.METHODS: The study comprised 24 obese women with PCOS and 29 obese Control women. Transthoracic echocardiography was used to evaluate LV structure/function. Basic clinical and metabolic data were collected for each participant consisting of age, BMI, blood pressure, fasting glucose, LDL-C, HLD-C, cholesterol and triglyceride levels. Exclusion criteria; BMI < 30 g/m2, type 2 diabetes, hypertension.RESULTS: Both groups exhibited concentric remodelling of the LV posterior wall at a prevalence of ~20%, this associated with grade 1 diastolic dysfunction. Estimated LV mass/height2.7 was increased patients with PCOS (45 ± 2.2 vs 37 ± 1.6) with 33% exhibiting LV mass/height2.7 above ASE guidelines, compared to 7% in Controls. Furthermore, 25% of patients with PCOS were characterised with concentric hypertrophy, an alteration in LV geometry that was not observed in the Control group.CONCLUSIONS: To our knowledge, this is the first study to assess LV geometric patterns in obese women with PCOS. The results suggest that obese women with PCOS are at greater risk of concentric hypertrophy than obese only women and provide justification for additional cardiovascular risk assessment in normotensive obese/PCOS women.

AB - BACKGROUND: It remains unclear as to whether polycystic ovary syndrome (PCOS) is an additional risk factor in the development of left ventricular (LV) hypertrophy in obese women. In the current study, we provide clarity on this issue by rigorously analysing patient LV geometry beyond the basic clinical measures currently used. Importantly, the cohort contained only normotensive patients that would normally be deemed low risk with no further intervention required.METHODS: The study comprised 24 obese women with PCOS and 29 obese Control women. Transthoracic echocardiography was used to evaluate LV structure/function. Basic clinical and metabolic data were collected for each participant consisting of age, BMI, blood pressure, fasting glucose, LDL-C, HLD-C, cholesterol and triglyceride levels. Exclusion criteria; BMI < 30 g/m2, type 2 diabetes, hypertension.RESULTS: Both groups exhibited concentric remodelling of the LV posterior wall at a prevalence of ~20%, this associated with grade 1 diastolic dysfunction. Estimated LV mass/height2.7 was increased patients with PCOS (45 ± 2.2 vs 37 ± 1.6) with 33% exhibiting LV mass/height2.7 above ASE guidelines, compared to 7% in Controls. Furthermore, 25% of patients with PCOS were characterised with concentric hypertrophy, an alteration in LV geometry that was not observed in the Control group.CONCLUSIONS: To our knowledge, this is the first study to assess LV geometric patterns in obese women with PCOS. The results suggest that obese women with PCOS are at greater risk of concentric hypertrophy than obese only women and provide justification for additional cardiovascular risk assessment in normotensive obese/PCOS women.

KW - Adult

KW - Blood Glucose

KW - Blood Pressure

KW - Cholesterol/blood

KW - Cholesterol, HDL/blood

KW - Cholesterol, LDL/blood

KW - Echocardiography

KW - Female

KW - Heart Failure, Diastolic/complications

KW - Heart Ventricles/diagnostic imaging

KW - Humans

KW - Hypertrophy, Left Ventricular/blood

KW - Obesity/blood

KW - Polycystic Ovary Syndrome/blood

KW - Triglycerides/blood

KW - Ventricular Function, Left/physiology

U2 - 10.1371/journal.pone.0263312

DO - 10.1371/journal.pone.0263312

M3 - SCORING: Journal article

C2 - 35213570

VL - 17

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 2

M1 - e0263312

ER -