Polyanions in Coagulation and Thrombosis: Focus on Polyphosphate and NETs
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Polyanions in Coagulation and Thrombosis: Focus on Polyphosphate and NETs. / Rangaswamy, Chandini; Englert, Hanna; Deppermann, Carsten; Renné, Thomas.
In: THROMB HAEMOSTASIS, Vol. 121, No. 8, 08.2021, p. 1021-1030.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Polyanions in Coagulation and Thrombosis: Focus on Polyphosphate and NETs
AU - Rangaswamy, Chandini
AU - Englert, Hanna
AU - Deppermann, Carsten
AU - Renné, Thomas
N1 - Thieme. All rights reserved.
PY - 2021/8
Y1 - 2021/8
N2 - Neutrophil extracellular traps (NETs) and polyphosphates (polyP) have been recognized as procoagulant polyanions. This review summarizes the activities and regulation of the two procoagulant mediators and compares their functions. NETs are composed of DNA which like polyP is built of phosphate units linked by high-energy phosphoanhydride bonds. Both NETs and polyP form insoluble particulate surfaces composed of a DNA/histone meshwork or Ca 2+-rich nanoparticles, respectively. These polyanionic molecules modulate coagulation involving an array of mechanisms and trigger thrombosis via activation of the factor XII-driven procoagulant and proinflammatory contact pathway. Here, we outline the current knowledge on NETs and polyP with respect to their procoagulant and prothrombotic nature, strategies for interference of their activities in circulation, as well as the crosstalk between these two molecules. A better understanding of the underlying, cellular mechanisms will shed light on the therapeutic potential of targeting NETs and polyP in coagulation and thrombosis.
AB - Neutrophil extracellular traps (NETs) and polyphosphates (polyP) have been recognized as procoagulant polyanions. This review summarizes the activities and regulation of the two procoagulant mediators and compares their functions. NETs are composed of DNA which like polyP is built of phosphate units linked by high-energy phosphoanhydride bonds. Both NETs and polyP form insoluble particulate surfaces composed of a DNA/histone meshwork or Ca 2+-rich nanoparticles, respectively. These polyanionic molecules modulate coagulation involving an array of mechanisms and trigger thrombosis via activation of the factor XII-driven procoagulant and proinflammatory contact pathway. Here, we outline the current knowledge on NETs and polyP with respect to their procoagulant and prothrombotic nature, strategies for interference of their activities in circulation, as well as the crosstalk between these two molecules. A better understanding of the underlying, cellular mechanisms will shed light on the therapeutic potential of targeting NETs and polyP in coagulation and thrombosis.
U2 - 10.1055/a-1336-0526
DO - 10.1055/a-1336-0526
M3 - SCORING: Review article
C2 - 33307564
VL - 121
SP - 1021
EP - 1030
JO - THROMB HAEMOSTASIS
JF - THROMB HAEMOSTASIS
SN - 0340-6245
IS - 8
ER -