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Platelet-derived lipids promote insulin secretion of pancreatic β cells

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Platelet-derived lipids promote insulin secretion of pancreatic β cells. / Karwen, Till; Kolczynska-Matysiak, Katarzyna; Gross, Carina; Löffler, Mona C; Friedrich, Mike; Loza-Valdes, Angel; Schmitz, Werner; Wit, Magdalena; Dziaczkowski, Filip; Belykh, Andrei; Trujillo-Viera, Jonathan; El-Merahbi, Rabih; Deppermann, Carsten; Nawaz, Sameena; Hastoy, Benoit; Demczuk, Agnieszka; Erk, Manuela; Wieckowski, Mariusz R; Rorsman, Patrik; Heinze, Katrin G; Stegner, David; Nieswandt, Bernhard; Sumara, Grzegorz.

In: EMBO MOL MED, Vol. 15, No. 9, 11.09.2023, p. e16858.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Karwen, T, Kolczynska-Matysiak, K, Gross, C, Löffler, MC, Friedrich, M, Loza-Valdes, A, Schmitz, W, Wit, M, Dziaczkowski, F, Belykh, A, Trujillo-Viera, J, El-Merahbi, R, Deppermann, C, Nawaz, S, Hastoy, B, Demczuk, A, Erk, M, Wieckowski, MR, Rorsman, P, Heinze, KG, Stegner, D, Nieswandt, B & Sumara, G 2023, 'Platelet-derived lipids promote insulin secretion of pancreatic β cells', EMBO MOL MED, vol. 15, no. 9, pp. e16858. https://doi.org/10.15252/emmm.202216858

APA

Karwen, T., Kolczynska-Matysiak, K., Gross, C., Löffler, M. C., Friedrich, M., Loza-Valdes, A., Schmitz, W., Wit, M., Dziaczkowski, F., Belykh, A., Trujillo-Viera, J., El-Merahbi, R., Deppermann, C., Nawaz, S., Hastoy, B., Demczuk, A., Erk, M., Wieckowski, M. R., Rorsman, P., ... Sumara, G. (2023). Platelet-derived lipids promote insulin secretion of pancreatic β cells. EMBO MOL MED, 15(9), e16858. https://doi.org/10.15252/emmm.202216858

Vancouver

Karwen T, Kolczynska-Matysiak K, Gross C, Löffler MC, Friedrich M, Loza-Valdes A et al. Platelet-derived lipids promote insulin secretion of pancreatic β cells. EMBO MOL MED. 2023 Sep 11;15(9):e16858. https://doi.org/10.15252/emmm.202216858

Bibtex

@article{622cbdf99c9e40ccab4ea8f1554812ec,
title = "Platelet-derived lipids promote insulin secretion of pancreatic β cells",
abstract = "Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. Pancreatic β cells are the central regulators of systemic glucose homeostasis. Here, we show that factor(s) derived from β cells stimulate platelet activity and platelets selectively localize to the vascular endothelium of pancreatic islets. Both depletion of platelets and ablation of major platelet adhesion or activation pathways consistently resulted in impaired glucose tolerance and decreased circulating insulin levels. Furthermore, we found platelet-derived lipid classes to promote insulin secretion and identified 20-Hydroxyeicosatetraenoic acid (20-HETE) as the main factor promoting β cells function. Finally, we demonstrate that the levels of platelet-derived 20-HETE decline with age and that this parallels with reduced impact of platelets on β cell function. Our findings identify an unexpected function of platelets in the regulation of insulin secretion and glucose metabolism, which promotes metabolic fitness in young individuals.",
author = "Till Karwen and Katarzyna Kolczynska-Matysiak and Carina Gross and L{\"o}ffler, {Mona C} and Mike Friedrich and Angel Loza-Valdes and Werner Schmitz and Magdalena Wit and Filip Dziaczkowski and Andrei Belykh and Jonathan Trujillo-Viera and Rabih El-Merahbi and Carsten Deppermann and Sameena Nawaz and Benoit Hastoy and Agnieszka Demczuk and Manuela Erk and Wieckowski, {Mariusz R} and Patrik Rorsman and Heinze, {Katrin G} and David Stegner and Bernhard Nieswandt and Grzegorz Sumara",
note = "{\textcopyright} 2023 The Authors. Published under the terms of the CC BY 4.0 license.",
year = "2023",
month = sep,
day = "11",
doi = "10.15252/emmm.202216858",
language = "English",
volume = "15",
pages = "e16858",
journal = "EMBO MOL MED",
issn = "1757-4676",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Platelet-derived lipids promote insulin secretion of pancreatic β cells

AU - Karwen, Till

AU - Kolczynska-Matysiak, Katarzyna

AU - Gross, Carina

AU - Löffler, Mona C

AU - Friedrich, Mike

AU - Loza-Valdes, Angel

AU - Schmitz, Werner

AU - Wit, Magdalena

AU - Dziaczkowski, Filip

AU - Belykh, Andrei

AU - Trujillo-Viera, Jonathan

AU - El-Merahbi, Rabih

AU - Deppermann, Carsten

AU - Nawaz, Sameena

AU - Hastoy, Benoit

AU - Demczuk, Agnieszka

AU - Erk, Manuela

AU - Wieckowski, Mariusz R

AU - Rorsman, Patrik

AU - Heinze, Katrin G

AU - Stegner, David

AU - Nieswandt, Bernhard

AU - Sumara, Grzegorz

N1 - © 2023 The Authors. Published under the terms of the CC BY 4.0 license.

PY - 2023/9/11

Y1 - 2023/9/11

N2 - Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. Pancreatic β cells are the central regulators of systemic glucose homeostasis. Here, we show that factor(s) derived from β cells stimulate platelet activity and platelets selectively localize to the vascular endothelium of pancreatic islets. Both depletion of platelets and ablation of major platelet adhesion or activation pathways consistently resulted in impaired glucose tolerance and decreased circulating insulin levels. Furthermore, we found platelet-derived lipid classes to promote insulin secretion and identified 20-Hydroxyeicosatetraenoic acid (20-HETE) as the main factor promoting β cells function. Finally, we demonstrate that the levels of platelet-derived 20-HETE decline with age and that this parallels with reduced impact of platelets on β cell function. Our findings identify an unexpected function of platelets in the regulation of insulin secretion and glucose metabolism, which promotes metabolic fitness in young individuals.

AB - Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. Pancreatic β cells are the central regulators of systemic glucose homeostasis. Here, we show that factor(s) derived from β cells stimulate platelet activity and platelets selectively localize to the vascular endothelium of pancreatic islets. Both depletion of platelets and ablation of major platelet adhesion or activation pathways consistently resulted in impaired glucose tolerance and decreased circulating insulin levels. Furthermore, we found platelet-derived lipid classes to promote insulin secretion and identified 20-Hydroxyeicosatetraenoic acid (20-HETE) as the main factor promoting β cells function. Finally, we demonstrate that the levels of platelet-derived 20-HETE decline with age and that this parallels with reduced impact of platelets on β cell function. Our findings identify an unexpected function of platelets in the regulation of insulin secretion and glucose metabolism, which promotes metabolic fitness in young individuals.

U2 - 10.15252/emmm.202216858

DO - 10.15252/emmm.202216858

M3 - SCORING: Journal article

C2 - 37490001

VL - 15

SP - e16858

JO - EMBO MOL MED

JF - EMBO MOL MED

SN - 1757-4676

IS - 9

ER -