Platelet P-selectin and GPIIb/IIIa expression after liver transplantation and resection.
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Platelet P-selectin and GPIIb/IIIa expression after liver transplantation and resection. / Becker, Thomas; Jüttner, Björn; Elsner, Holger-Andreas; Andreas, Meyer Zu Vilsendorf; Bornscheuer, Albrecht; Nashan, Björn; Brandl, Michael; Klempnauer, Jürgen; Piepenbrock, Siegfried; Scheinichen, Dirk.
In: TRANSPL INT, Vol. 17, No. 8, 8, 2004, p. 442-448.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Platelet P-selectin and GPIIb/IIIa expression after liver transplantation and resection.
AU - Becker, Thomas
AU - Jüttner, Björn
AU - Elsner, Holger-Andreas
AU - Andreas, Meyer Zu Vilsendorf
AU - Bornscheuer, Albrecht
AU - Nashan, Björn
AU - Brandl, Michael
AU - Klempnauer, Jürgen
AU - Piepenbrock, Siegfried
AU - Scheinichen, Dirk
PY - 2004
Y1 - 2004
N2 - Platelet dysfunction contributes to haemostatic defects, possibly leading to bleeding complications. We hypothesised that liver transplantation and liver resection, together with portal clamping time, might be a potential stimulus for platelet activation. Therefore, we determined the expression of platelet GPIIb/IIIa and P-selectin, representing important platelet activation markers, and the thrombopoietin (TPO) serum level after transplantation and resection. Twenty patients [ten that had undergone orthotopic liver transplantation (OLT), ten with liver resection (LRX)] were included in the study. From sequential venous blood samples, surface expression of GPIIb/IIIa and P-selectin was quantified by flow cytometry, and TPO serum levels were determined by ELISA. Baseline GPIIb/IIIa receptor expression on circulating platelets was significantly reduced in the OLT group compared to the LRX group and healthy volunteers. GPIIb/IIIa expression after activation with TRAP-6 increased significantly ( P
AB - Platelet dysfunction contributes to haemostatic defects, possibly leading to bleeding complications. We hypothesised that liver transplantation and liver resection, together with portal clamping time, might be a potential stimulus for platelet activation. Therefore, we determined the expression of platelet GPIIb/IIIa and P-selectin, representing important platelet activation markers, and the thrombopoietin (TPO) serum level after transplantation and resection. Twenty patients [ten that had undergone orthotopic liver transplantation (OLT), ten with liver resection (LRX)] were included in the study. From sequential venous blood samples, surface expression of GPIIb/IIIa and P-selectin was quantified by flow cytometry, and TPO serum levels were determined by ELISA. Baseline GPIIb/IIIa receptor expression on circulating platelets was significantly reduced in the OLT group compared to the LRX group and healthy volunteers. GPIIb/IIIa expression after activation with TRAP-6 increased significantly ( P
M3 - SCORING: Zeitschriftenaufsatz
VL - 17
SP - 442
EP - 448
JO - TRANSPL INT
JF - TRANSPL INT
SN - 0934-0874
IS - 8
M1 - 8
ER -