Platelet lifespan and mechanisms for clearance

Olga An; Carsten Deppermann

doi:10.1097/MOH.0000000000000792

Platelet lifespan and mechanisms for clearance

Standard

Platelet lifespan and mechanisms for clearance. / An, Olga; Deppermann, Carsten.

In: CURR OPIN HEMATOL, Vol. 31, No. 1, 01.01.2024, p. 6-15.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

An, O & Deppermann, C 2024, 'Platelet lifespan and mechanisms for clearance', CURR OPIN HEMATOL, vol. 31, no. 1, pp. 6-15. https://doi.org/10.1097/MOH.0000000000000792

APA

An, O., & Deppermann, C. (2024). Platelet lifespan and mechanisms for clearance. CURR OPIN HEMATOL, 31(1), 6-15. https://doi.org/10.1097/MOH.0000000000000792

Vancouver

An O, Deppermann C. Platelet lifespan and mechanisms for clearance. CURR OPIN HEMATOL. 2024 Jan 1;31(1):6-15. https://doi.org/10.1097/MOH.0000000000000792

Bibtex

@article{a99283fc2439472eb0b7910e2a080c4a,

title = "Platelet lifespan and mechanisms for clearance",

abstract = "PURPOSE OF REVIEW: Activated or aged platelets are removed from circulation under (patho)physiologic conditions, the exact mechanism of platelet clearance under such conditions remains unclear and are currently being investigated. This review focuses on recent findings and controversies regarding platelet clearance and the disruption of platelet life cycle.RECENT FINDINGS: The platelet life span is determined by glycosylation of platelet surface receptors with sialic acid. Recently, it was shown that platelet activation and granule release leads to desialylation of glycans and accelerated clearance of platelets under pathological conditions. This phenomenon was demonstrated to be a main reason for thrombocytopenia being a complication in several infections and immune disorders.SUMMARY: Although we have recently gained some insight into how aged platelets are cleared from circulation, we are still not seeing the full picture. Further investigations of the platelet clearance pathways under pathophysiologic conditions are needed as well as studies to unravel the connection between platelet clearance and platelet production.",

keywords = "Humans, Aged, Longevity, Blood Platelets/metabolism, Thrombocytopenia/etiology, N-Acetylneuraminic Acid/metabolism, Polysaccharides",

author = "Olga An and Carsten Deppermann",

year = "2024",

month = jan,

day = "1",

doi = "10.1097/MOH.0000000000000792",

language = "English",

volume = "31",

pages = "6--15",

journal = "CURR OPIN HEMATOL",

issn = "1065-6251",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

RIS

TY - JOUR

T1 - Platelet lifespan and mechanisms for clearance

AU - An, Olga

AU - Deppermann, Carsten

PY - 2024/1/1

Y1 - 2024/1/1

N2 - PURPOSE OF REVIEW: Activated or aged platelets are removed from circulation under (patho)physiologic conditions, the exact mechanism of platelet clearance under such conditions remains unclear and are currently being investigated. This review focuses on recent findings and controversies regarding platelet clearance and the disruption of platelet life cycle.RECENT FINDINGS: The platelet life span is determined by glycosylation of platelet surface receptors with sialic acid. Recently, it was shown that platelet activation and granule release leads to desialylation of glycans and accelerated clearance of platelets under pathological conditions. This phenomenon was demonstrated to be a main reason for thrombocytopenia being a complication in several infections and immune disorders.SUMMARY: Although we have recently gained some insight into how aged platelets are cleared from circulation, we are still not seeing the full picture. Further investigations of the platelet clearance pathways under pathophysiologic conditions are needed as well as studies to unravel the connection between platelet clearance and platelet production.

AB - PURPOSE OF REVIEW: Activated or aged platelets are removed from circulation under (patho)physiologic conditions, the exact mechanism of platelet clearance under such conditions remains unclear and are currently being investigated. This review focuses on recent findings and controversies regarding platelet clearance and the disruption of platelet life cycle.RECENT FINDINGS: The platelet life span is determined by glycosylation of platelet surface receptors with sialic acid. Recently, it was shown that platelet activation and granule release leads to desialylation of glycans and accelerated clearance of platelets under pathological conditions. This phenomenon was demonstrated to be a main reason for thrombocytopenia being a complication in several infections and immune disorders.SUMMARY: Although we have recently gained some insight into how aged platelets are cleared from circulation, we are still not seeing the full picture. Further investigations of the platelet clearance pathways under pathophysiologic conditions are needed as well as studies to unravel the connection between platelet clearance and platelet production.

KW - Humans

KW - Aged

KW - Longevity

KW - Blood Platelets/metabolism

KW - Thrombocytopenia/etiology

KW - N-Acetylneuraminic Acid/metabolism

KW - Polysaccharides

U2 - 10.1097/MOH.0000000000000792

DO - 10.1097/MOH.0000000000000792

M3 - SCORING: Review article

C2 - 37905750

VL - 31

SP - 6

EP - 15

JO - CURR OPIN HEMATOL

JF - CURR OPIN HEMATOL

SN - 1065-6251

IS - 1

ER -