Plasmodium falciparum glycosylphosphatidylinositol induces limited apoptosis in liver and spleen mouse tissue.
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Plasmodium falciparum glycosylphosphatidylinositol induces limited apoptosis in liver and spleen mouse tissue. / Wichmann, Dominic; Schwarz, Ralph T; Ruppert, Volker; Ehrhardt, Stephan; Cramer, Jakob; Burchard, Gerd-Dieter; Maisch, Bernhard; Debierre-Grockiego, Françoise.
In: APOPTOSIS, Vol. 12, No. 6, 6, 2007, p. 1037-1041.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Plasmodium falciparum glycosylphosphatidylinositol induces limited apoptosis in liver and spleen mouse tissue.
AU - Wichmann, Dominic
AU - Schwarz, Ralph T
AU - Ruppert, Volker
AU - Ehrhardt, Stephan
AU - Cramer, Jakob
AU - Burchard, Gerd-Dieter
AU - Maisch, Bernhard
AU - Debierre-Grockiego, Françoise
PY - 2007
Y1 - 2007
N2 - Plasmodium falciparum malaria affects about 500 million people worldwide and is responsible for approximately 2.5 million deaths per year. Glycosylphosphatidylinositol (GPI) is the major anchor for membrane-associated proteins of P. falciparum and GPI plays a major role as a toxin in the pathology of malaria. Therefore, we tested the hypothesis that GPI, like LPS, induces apoptosis in vitro and in vital organs of mice. Our data does not provide evidence for direct cardiomyocyte apoptosis induced by GPI in vitro. However, in vivo injection of GPI induced limited apoptosis in mouse liver and spleen tissue. Apoptosis may be due to a direct GPI apoptotic effect or to an indirect effect via the induction of TNFalpha and nitric oxide production.
AB - Plasmodium falciparum malaria affects about 500 million people worldwide and is responsible for approximately 2.5 million deaths per year. Glycosylphosphatidylinositol (GPI) is the major anchor for membrane-associated proteins of P. falciparum and GPI plays a major role as a toxin in the pathology of malaria. Therefore, we tested the hypothesis that GPI, like LPS, induces apoptosis in vitro and in vital organs of mice. Our data does not provide evidence for direct cardiomyocyte apoptosis induced by GPI in vitro. However, in vivo injection of GPI induced limited apoptosis in mouse liver and spleen tissue. Apoptosis may be due to a direct GPI apoptotic effect or to an indirect effect via the induction of TNFalpha and nitric oxide production.
M3 - SCORING: Zeitschriftenaufsatz
VL - 12
SP - 1037
EP - 1041
JO - APOPTOSIS
JF - APOPTOSIS
SN - 1360-8185
IS - 6
M1 - 6
ER -