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Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease

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Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease. / Imhof, Armin; Rothenbacher, Dietrich; Khuseyinova, Natalie; Hoffmeister, Albrecht; Maerz, Winfried; Nauck, Matthias; Scharnagl, Hubert; Koenig, Wolfgang; Brenner, Hermann.

In: EUR J PREV CARDIOL, Vol. 10, No. 5, 10.2003, p. 362-370.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Imhof, A, Rothenbacher, D, Khuseyinova, N, Hoffmeister, A, Maerz, W, Nauck, M, Scharnagl, H, Koenig, W & Brenner, H 2003, 'Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease', EUR J PREV CARDIOL, vol. 10, no. 5, pp. 362-370. https://doi.org/10.1097/01.hjr.0000087080.83314.be

APA

Imhof, A., Rothenbacher, D., Khuseyinova, N., Hoffmeister, A., Maerz, W., Nauck, M., Scharnagl, H., Koenig, W., & Brenner, H. (2003). Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease. EUR J PREV CARDIOL, 10(5), 362-370. https://doi.org/10.1097/01.hjr.0000087080.83314.be

Vancouver

Imhof A, Rothenbacher D, Khuseyinova N, Hoffmeister A, Maerz W, Nauck M et al. Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease. EUR J PREV CARDIOL. 2003 Oct;10(5):362-370. https://doi.org/10.1097/01.hjr.0000087080.83314.be

Bibtex

@article{bd484e0fa44743db9aa9b896fc8f3d14,
title = "Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease",
abstract = "BACKGROUND: Elevated plasma (Lp(a)) levels may represent an independent risk factor for atherothrombotic complications but the relation between Lp(a) levels and the extent of coronary artery disease (CHD) has been discussed controversially. Little is known about potential atherothrombogenic mechanisms of Lp(a).DESIGN: Case-control study.METHODS: We assessed the relationship between plasma Lp(a) and angiographically defined CHD, evaluating the severity of coronary atherosclerosis by three different scores. A total of 312 patients with stable angina aged 40-68 years with at least one coronary stenosis > 50% were studied. A group of 479 voluntary blood donors matched for age and sex served as controls. A complete lipid profile and a large number of markers of coagulation, fibrinolysis and inflammation were measured.RESULTS: Plasma levels of Lp(a) were significantly higher in patients (14.8 mg/dl; 5.4-47.1 mg/dl; median/interquartile range) than in controls (9.7 mg/dl; 3.5-25.3) (P<0.0001). In a logistic regression model, the fully adjusted Odds Ratio for CHD was 3.3 (95% confidence interval (CI) 1.8-5.6, P<0.0001) for patients in the upper quartile of the Lp(a) distribution compared to the bottom quartile. There was no appreciable association between Lp(a) and apolipoproteins, markers of haemostasis, fibrinolysis and inflammation and the severity of CHD.CONCLUSIONS: These results indicate that elevated plasma Lp(a) levels may be an independent risk factor for CHD but unrelated to the severity and extension of CHD. Furthermore, there is no good evidence that the presumed link between Lp(a) and CHD is mediated by increased levels of markers of inflammation, or interference with markers of fibrinolysis or coagulation.",
keywords = "Adaptation, Biological, Adult, Aged, Blood Coagulation Factors/analysis, Case-Control Studies, Coronary Angiography, Coronary Disease/blood, Humans, Inflammation/blood, Lipoprotein(a)/blood, Logistic Models, Middle Aged, Multivariate Analysis, Risk Factors",
author = "Armin Imhof and Dietrich Rothenbacher and Natalie Khuseyinova and Albrecht Hoffmeister and Winfried Maerz and Matthias Nauck and Hubert Scharnagl and Wolfgang Koenig and Hermann Brenner",
year = "2003",
month = oct,
doi = "10.1097/01.hjr.0000087080.83314.be",
language = "English",
volume = "10",
pages = "362--370",
journal = "EUR J PREV CARDIOL",
issn = "2047-4873",
publisher = "SAGE Publications",
number = "5",

}

RIS

TY - JOUR

T1 - Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease

AU - Imhof, Armin

AU - Rothenbacher, Dietrich

AU - Khuseyinova, Natalie

AU - Hoffmeister, Albrecht

AU - Maerz, Winfried

AU - Nauck, Matthias

AU - Scharnagl, Hubert

AU - Koenig, Wolfgang

AU - Brenner, Hermann

PY - 2003/10

Y1 - 2003/10

N2 - BACKGROUND: Elevated plasma (Lp(a)) levels may represent an independent risk factor for atherothrombotic complications but the relation between Lp(a) levels and the extent of coronary artery disease (CHD) has been discussed controversially. Little is known about potential atherothrombogenic mechanisms of Lp(a).DESIGN: Case-control study.METHODS: We assessed the relationship between plasma Lp(a) and angiographically defined CHD, evaluating the severity of coronary atherosclerosis by three different scores. A total of 312 patients with stable angina aged 40-68 years with at least one coronary stenosis > 50% were studied. A group of 479 voluntary blood donors matched for age and sex served as controls. A complete lipid profile and a large number of markers of coagulation, fibrinolysis and inflammation were measured.RESULTS: Plasma levels of Lp(a) were significantly higher in patients (14.8 mg/dl; 5.4-47.1 mg/dl; median/interquartile range) than in controls (9.7 mg/dl; 3.5-25.3) (P<0.0001). In a logistic regression model, the fully adjusted Odds Ratio for CHD was 3.3 (95% confidence interval (CI) 1.8-5.6, P<0.0001) for patients in the upper quartile of the Lp(a) distribution compared to the bottom quartile. There was no appreciable association between Lp(a) and apolipoproteins, markers of haemostasis, fibrinolysis and inflammation and the severity of CHD.CONCLUSIONS: These results indicate that elevated plasma Lp(a) levels may be an independent risk factor for CHD but unrelated to the severity and extension of CHD. Furthermore, there is no good evidence that the presumed link between Lp(a) and CHD is mediated by increased levels of markers of inflammation, or interference with markers of fibrinolysis or coagulation.

AB - BACKGROUND: Elevated plasma (Lp(a)) levels may represent an independent risk factor for atherothrombotic complications but the relation between Lp(a) levels and the extent of coronary artery disease (CHD) has been discussed controversially. Little is known about potential atherothrombogenic mechanisms of Lp(a).DESIGN: Case-control study.METHODS: We assessed the relationship between plasma Lp(a) and angiographically defined CHD, evaluating the severity of coronary atherosclerosis by three different scores. A total of 312 patients with stable angina aged 40-68 years with at least one coronary stenosis > 50% were studied. A group of 479 voluntary blood donors matched for age and sex served as controls. A complete lipid profile and a large number of markers of coagulation, fibrinolysis and inflammation were measured.RESULTS: Plasma levels of Lp(a) were significantly higher in patients (14.8 mg/dl; 5.4-47.1 mg/dl; median/interquartile range) than in controls (9.7 mg/dl; 3.5-25.3) (P<0.0001). In a logistic regression model, the fully adjusted Odds Ratio for CHD was 3.3 (95% confidence interval (CI) 1.8-5.6, P<0.0001) for patients in the upper quartile of the Lp(a) distribution compared to the bottom quartile. There was no appreciable association between Lp(a) and apolipoproteins, markers of haemostasis, fibrinolysis and inflammation and the severity of CHD.CONCLUSIONS: These results indicate that elevated plasma Lp(a) levels may be an independent risk factor for CHD but unrelated to the severity and extension of CHD. Furthermore, there is no good evidence that the presumed link between Lp(a) and CHD is mediated by increased levels of markers of inflammation, or interference with markers of fibrinolysis or coagulation.

KW - Adaptation, Biological

KW - Adult

KW - Aged

KW - Blood Coagulation Factors/analysis

KW - Case-Control Studies

KW - Coronary Angiography

KW - Coronary Disease/blood

KW - Humans

KW - Inflammation/blood

KW - Lipoprotein(a)/blood

KW - Logistic Models

KW - Middle Aged

KW - Multivariate Analysis

KW - Risk Factors

U2 - 10.1097/01.hjr.0000087080.83314.be

DO - 10.1097/01.hjr.0000087080.83314.be

M3 - SCORING: Journal article

C2 - 14663298

VL - 10

SP - 362

EP - 370

JO - EUR J PREV CARDIOL

JF - EUR J PREV CARDIOL

SN - 2047-4873

IS - 5

ER -