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Plasma concentrations of N-terminal pro-brain natriuretic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure

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Plasma concentrations of N-terminal pro-brain natriuretic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure. / Mir, Thomas S; Marohn, Sönke; Läer, Stephanie; Eiselt, Michele; Grollmus, Oswin; Weil, Jochen.

In: PEDIATRICS, Vol. 110, No. 6, 12.2002, p. e76.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mir, TS, Marohn, S, Läer, S, Eiselt, M, Grollmus, O & Weil, J 2002, 'Plasma concentrations of N-terminal pro-brain natriuretic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure', PEDIATRICS, vol. 110, no. 6, pp. e76. https://doi.org/10.1542/peds.110.6.e76

APA

Mir, T. S., Marohn, S., Läer, S., Eiselt, M., Grollmus, O., & Weil, J. (2002). Plasma concentrations of N-terminal pro-brain natriuretic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure. PEDIATRICS, 110(6), e76. https://doi.org/10.1542/peds.110.6.e76

Vancouver

Mir TS, Marohn S, Läer S, Eiselt M, Grollmus O, Weil J. Plasma concentrations of N-terminal pro-brain natriuretic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure. PEDIATRICS. 2002 Dec;110(6):e76. https://doi.org/10.1542/peds.110.6.e76

Bibtex

@article{3a7180993b3c4627bde9a3063e84c97b,
title = "Plasma concentrations of N-terminal pro-brain natriuretic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure",
abstract = "OBJECTIVE: To determine plasma levels of N-terminal pro-brain natriuretic peptide (N-BNP) in control children to establish a normal age-dependent range from the neonatal period to adulthood. In addition, plasma concentrations of N-BNP were measured in children with congestive heart failure (CHF) and correlated with ejection fraction and clinical symptoms of heart failure.METHODS: For establishing a normal age-dependent range of plasma N-BNP, venous blood samples were taken in 133 control patients from the neonatal period to adulthood (10 days-32 years) and in 31 children with CHF. Plasma N-BNP levels were determined by an enzyme immunoassay. In children (1 month-14 years) with CHF, plasma N-BNP levels were correlated to ejection fraction measured by echocardiography and clinical symptoms of heart failure using the Ross Score.RESULTS: N-BNP levels in control children, adolescents, and adults did not show a significant age-related difference. In control children, the normal range was established between 150 (10th percentile) and 430 fmol/mL (90th percentile). Mean plasma N-BNP in control children was 311 fmol/mL (range: 74-654 fmol/mL). In 31 children with CHF, the plasma N-BNP levels were significantly higher (mean: 846; range: 219-2718) than in control children. N-BNP levels showed a negative correlation with the ejection fraction (r = -0.53) and a positive correlation with the clinical heart failure score (r = 0.74).CONCLUSIONS: Plasma N-BNP levels reflect the severity of symptoms of heart failure and the impairment of cardiac function in children with CHF. In the future, determination of plasma N-BNP levels may be used as a helpful adjunct to monitor the effect of various treatments for CHF in children.",
keywords = "Adolescent, Adult, Angiotensin-Converting Enzyme Inhibitors/therapeutic use, Child, Child, Preschool, Digoxin/therapeutic use, Diuretics/therapeutic use, Echocardiography, Heart Failure/blood, Humans, Infant, Infant, Newborn, Natriuretic Peptide, Brain, Nerve Tissue Proteins/blood, Peptide Fragments/blood, Protein Precursors/blood, Reference Values, Severity of Illness Index, Stroke Volume",
author = "Mir, {Thomas S} and S{\"o}nke Marohn and Stephanie L{\"a}er and Michele Eiselt and Oswin Grollmus and Jochen Weil",
year = "2002",
month = dec,
doi = "10.1542/peds.110.6.e76",
language = "English",
volume = "110",
pages = "e76",
journal = "PEDIATRICS",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "6",

}

RIS

TY - JOUR

T1 - Plasma concentrations of N-terminal pro-brain natriuretic peptide in control children from the neonatal to adolescent period and in children with congestive heart failure

AU - Mir, Thomas S

AU - Marohn, Sönke

AU - Läer, Stephanie

AU - Eiselt, Michele

AU - Grollmus, Oswin

AU - Weil, Jochen

PY - 2002/12

Y1 - 2002/12

N2 - OBJECTIVE: To determine plasma levels of N-terminal pro-brain natriuretic peptide (N-BNP) in control children to establish a normal age-dependent range from the neonatal period to adulthood. In addition, plasma concentrations of N-BNP were measured in children with congestive heart failure (CHF) and correlated with ejection fraction and clinical symptoms of heart failure.METHODS: For establishing a normal age-dependent range of plasma N-BNP, venous blood samples were taken in 133 control patients from the neonatal period to adulthood (10 days-32 years) and in 31 children with CHF. Plasma N-BNP levels were determined by an enzyme immunoassay. In children (1 month-14 years) with CHF, plasma N-BNP levels were correlated to ejection fraction measured by echocardiography and clinical symptoms of heart failure using the Ross Score.RESULTS: N-BNP levels in control children, adolescents, and adults did not show a significant age-related difference. In control children, the normal range was established between 150 (10th percentile) and 430 fmol/mL (90th percentile). Mean plasma N-BNP in control children was 311 fmol/mL (range: 74-654 fmol/mL). In 31 children with CHF, the plasma N-BNP levels were significantly higher (mean: 846; range: 219-2718) than in control children. N-BNP levels showed a negative correlation with the ejection fraction (r = -0.53) and a positive correlation with the clinical heart failure score (r = 0.74).CONCLUSIONS: Plasma N-BNP levels reflect the severity of symptoms of heart failure and the impairment of cardiac function in children with CHF. In the future, determination of plasma N-BNP levels may be used as a helpful adjunct to monitor the effect of various treatments for CHF in children.

AB - OBJECTIVE: To determine plasma levels of N-terminal pro-brain natriuretic peptide (N-BNP) in control children to establish a normal age-dependent range from the neonatal period to adulthood. In addition, plasma concentrations of N-BNP were measured in children with congestive heart failure (CHF) and correlated with ejection fraction and clinical symptoms of heart failure.METHODS: For establishing a normal age-dependent range of plasma N-BNP, venous blood samples were taken in 133 control patients from the neonatal period to adulthood (10 days-32 years) and in 31 children with CHF. Plasma N-BNP levels were determined by an enzyme immunoassay. In children (1 month-14 years) with CHF, plasma N-BNP levels were correlated to ejection fraction measured by echocardiography and clinical symptoms of heart failure using the Ross Score.RESULTS: N-BNP levels in control children, adolescents, and adults did not show a significant age-related difference. In control children, the normal range was established between 150 (10th percentile) and 430 fmol/mL (90th percentile). Mean plasma N-BNP in control children was 311 fmol/mL (range: 74-654 fmol/mL). In 31 children with CHF, the plasma N-BNP levels were significantly higher (mean: 846; range: 219-2718) than in control children. N-BNP levels showed a negative correlation with the ejection fraction (r = -0.53) and a positive correlation with the clinical heart failure score (r = 0.74).CONCLUSIONS: Plasma N-BNP levels reflect the severity of symptoms of heart failure and the impairment of cardiac function in children with CHF. In the future, determination of plasma N-BNP levels may be used as a helpful adjunct to monitor the effect of various treatments for CHF in children.

KW - Adolescent

KW - Adult

KW - Angiotensin-Converting Enzyme Inhibitors/therapeutic use

KW - Child

KW - Child, Preschool

KW - Digoxin/therapeutic use

KW - Diuretics/therapeutic use

KW - Echocardiography

KW - Heart Failure/blood

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Natriuretic Peptide, Brain

KW - Nerve Tissue Proteins/blood

KW - Peptide Fragments/blood

KW - Protein Precursors/blood

KW - Reference Values

KW - Severity of Illness Index

KW - Stroke Volume

U2 - 10.1542/peds.110.6.e76

DO - 10.1542/peds.110.6.e76

M3 - SCORING: Journal article

C2 - 12456943

VL - 110

SP - e76

JO - PEDIATRICS

JF - PEDIATRICS

SN - 0031-4005

IS - 6

ER -