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Placebo and nocebo effects in depression: Implications for treatment and clinical trial designs

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Placebo and nocebo effects in depression: Implications for treatment and clinical trial designs. / Rief, Winfried; Kelley, John M.; Nestoriuc, Yvonne.

Placebo Effects Through the Lens of Translational Research. ed. / Luana Colloca; Jason Noel; Patricia D. Franklin; Chamindi Seneviratne. 1 . ed. Oxford : Oxford University Press, 2023. p. 215–228.

Research output: SCORING: Contribution to book/anthology › Chapter › Research › peer-review

Harvard

Rief, W, Kelley, JM & Nestoriuc, Y 2023, Placebo and nocebo effects in depression: Implications for treatment and clinical trial designs. in L Colloca, J Noel, PD Franklin & C Seneviratne (eds), Placebo Effects Through the Lens of Translational Research. 1 edn, Oxford University Press, Oxford, pp. 215–228. https://doi.org/10.1093/med/9780197645444.003.0016

APA

Rief, W., Kelley, J. M., & Nestoriuc, Y. (2023). Placebo and nocebo effects in depression: Implications for treatment and clinical trial designs. In L. Colloca, J. Noel, P. D. Franklin, & C. Seneviratne (Eds.), Placebo Effects Through the Lens of Translational Research (1 ed., pp. 215–228). Oxford University Press. https://doi.org/10.1093/med/9780197645444.003.0016

Vancouver

Rief W, Kelley JM, Nestoriuc Y. Placebo and nocebo effects in depression: Implications for treatment and clinical trial designs. In Colloca L, Noel J, Franklin PD, Seneviratne C, editors, Placebo Effects Through the Lens of Translational Research. 1 ed. Oxford: Oxford University Press. 2023. p. 215–228 https://doi.org/10.1093/med/9780197645444.003.0016

Bibtex

@inbook{2d01d116f7dd4a8593bc263cb0a5a4ab,
title = "Placebo and nocebo effects in depression: Implications for treatment and clinical trial designs",
abstract = "This chapter reviews evidence for placebo and nocebo effects in depression, including their mechanisms of action. The authors then consider how these effects could be used clinically. Meta-analyses indicate that antidepressants provide only marginal benefits over placebos, which suggests that placebos could benefit patients nearly as much as antidepressants do, but without medication side effects. Open-label placebos are a promising avenue for evoking these effects. It is also presented evidence for expectancy as an important mechanism underlying placebo and nocebo effects. It is discussed how expectancies regarding treatment efficacy and side effects could be manipulated to reduce side effects and improve clinical outcomes. In particular, the authors discuss how communication strategies such as contextualizing informed consent and framing treatment information can optimize treatment expectations, improve clinical outcomes, and reduce nocebo-related side effects. Finally, implications that such expectancy manipulations might have for clinical trial design are covered.",
author = "Winfried Rief and Kelley, {John M.} and Yvonne Nestoriuc",
year = "2023",
month = nov,
day = "1",
doi = "10.1093/med/9780197645444.003.0016",
language = "English",
isbn = "9780197645444",
pages = "215–228",
editor = "Luana Colloca and Jason Noel and Franklin, {Patricia D.} and Chamindi Seneviratne",
booktitle = "Placebo Effects Through the Lens of Translational Research",
publisher = "Oxford University Press",
address = "United Kingdom",
edition = "1 ",

}

RIS

TY - CHAP

T1 - Placebo and nocebo effects in depression: Implications for treatment and clinical trial designs

AU - Rief, Winfried

AU - Kelley, John M.

AU - Nestoriuc, Yvonne

PY - 2023/11/1

Y1 - 2023/11/1

N2 - This chapter reviews evidence for placebo and nocebo effects in depression, including their mechanisms of action. The authors then consider how these effects could be used clinically. Meta-analyses indicate that antidepressants provide only marginal benefits over placebos, which suggests that placebos could benefit patients nearly as much as antidepressants do, but without medication side effects. Open-label placebos are a promising avenue for evoking these effects. It is also presented evidence for expectancy as an important mechanism underlying placebo and nocebo effects. It is discussed how expectancies regarding treatment efficacy and side effects could be manipulated to reduce side effects and improve clinical outcomes. In particular, the authors discuss how communication strategies such as contextualizing informed consent and framing treatment information can optimize treatment expectations, improve clinical outcomes, and reduce nocebo-related side effects. Finally, implications that such expectancy manipulations might have for clinical trial design are covered.

AB - This chapter reviews evidence for placebo and nocebo effects in depression, including their mechanisms of action. The authors then consider how these effects could be used clinically. Meta-analyses indicate that antidepressants provide only marginal benefits over placebos, which suggests that placebos could benefit patients nearly as much as antidepressants do, but without medication side effects. Open-label placebos are a promising avenue for evoking these effects. It is also presented evidence for expectancy as an important mechanism underlying placebo and nocebo effects. It is discussed how expectancies regarding treatment efficacy and side effects could be manipulated to reduce side effects and improve clinical outcomes. In particular, the authors discuss how communication strategies such as contextualizing informed consent and framing treatment information can optimize treatment expectations, improve clinical outcomes, and reduce nocebo-related side effects. Finally, implications that such expectancy manipulations might have for clinical trial design are covered.

U2 - 10.1093/med/9780197645444.003.0016

DO - 10.1093/med/9780197645444.003.0016

M3 - Chapter

SN - 9780197645444

SP - 215

EP - 228

BT - Placebo Effects Through the Lens of Translational Research

A2 - Colloca, Luana

A2 - Noel, Jason

A2 - Franklin, Patricia D.

A2 - Seneviratne, Chamindi

PB - Oxford University Press

CY - Oxford

ER -