Placebo analgesia - A predictive coding perspective

Christian Büchel; Stephan Geuter; Christian Sprenger; Falk Eippert

doi:10.1016/j.neuron.2014.02.042

Placebo analgesia - A predictive coding perspective

Standard

Placebo analgesia - A predictive coding perspective. / Büchel, Christian; Geuter, Stephan; Sprenger, Christian; Eippert, Falk.

In: NEURON, Vol. 81, No. 6, 19.03.2014, p. 1223-39.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Büchel, C, Geuter, S, Sprenger, C & Eippert, F 2014, 'Placebo analgesia - A predictive coding perspective', NEURON, vol. 81, no. 6, pp. 1223-39. https://doi.org/10.1016/j.neuron.2014.02.042

APA

Büchel, C., Geuter, S., Sprenger, C., & Eippert, F. (2014). Placebo analgesia - A predictive coding perspective. NEURON, 81(6), 1223-39. https://doi.org/10.1016/j.neuron.2014.02.042

Vancouver

Büchel C, Geuter S, Sprenger C, Eippert F. Placebo analgesia - A predictive coding perspective. NEURON. 2014 Mar 19;81(6):1223-39. https://doi.org/10.1016/j.neuron.2014.02.042

Bibtex

@article{c060e6ee136f4475afb667b40708ea24,

title = "Placebo analgesia - A predictive coding perspective",

abstract = "This Perspective reviews recent findings in placebo hypoalgesia and provides a conceptual account of how expectations and experience can lead to placebo hypoalgesia. In particular, we put forward the idea that the ascending and the descending pain system resembles a recurrent system that allows for the implementation of predictive coding-meaning that the brain is not passively waiting for nociceptive stimuli to impinge on it but is actively making inferences based on prior experience and expectations. The Bayesian formulation within the predictive coding framework can directly account for differences in the magnitude but also the precision of expectations that are known to influence the strength of placebo hypoalgesia. We discuss how modulatory neurotransmitters such as opioids might be related to the characterization of expectations with an emphasis on the precision of these expectations. Finally, we develop experimental strategies that are suited to test this framework at the behavioral and neuronal level.",

keywords = "Analgesia, Analgesics, Opioid, Animals, Brain, Humans, Pain, Placebos, Predictive Value of Tests",

author = "Christian B{\"u}chel and Stephan Geuter and Christian Sprenger and Falk Eippert",

year = "2014",

month = mar,

day = "19",

doi = "10.1016/j.neuron.2014.02.042",

language = "English",

volume = "81",

pages = "1223--39",

journal = "NEURON",

issn = "0896-6273",

publisher = "Cell Press",

number = "6",

}

RIS

TY - JOUR

T1 - Placebo analgesia - A predictive coding perspective

AU - Büchel, Christian

AU - Geuter, Stephan

AU - Sprenger, Christian

AU - Eippert, Falk

PY - 2014/3/19

Y1 - 2014/3/19

N2 - This Perspective reviews recent findings in placebo hypoalgesia and provides a conceptual account of how expectations and experience can lead to placebo hypoalgesia. In particular, we put forward the idea that the ascending and the descending pain system resembles a recurrent system that allows for the implementation of predictive coding-meaning that the brain is not passively waiting for nociceptive stimuli to impinge on it but is actively making inferences based on prior experience and expectations. The Bayesian formulation within the predictive coding framework can directly account for differences in the magnitude but also the precision of expectations that are known to influence the strength of placebo hypoalgesia. We discuss how modulatory neurotransmitters such as opioids might be related to the characterization of expectations with an emphasis on the precision of these expectations. Finally, we develop experimental strategies that are suited to test this framework at the behavioral and neuronal level.

AB - This Perspective reviews recent findings in placebo hypoalgesia and provides a conceptual account of how expectations and experience can lead to placebo hypoalgesia. In particular, we put forward the idea that the ascending and the descending pain system resembles a recurrent system that allows for the implementation of predictive coding-meaning that the brain is not passively waiting for nociceptive stimuli to impinge on it but is actively making inferences based on prior experience and expectations. The Bayesian formulation within the predictive coding framework can directly account for differences in the magnitude but also the precision of expectations that are known to influence the strength of placebo hypoalgesia. We discuss how modulatory neurotransmitters such as opioids might be related to the characterization of expectations with an emphasis on the precision of these expectations. Finally, we develop experimental strategies that are suited to test this framework at the behavioral and neuronal level.

KW - Analgesia

KW - Analgesics, Opioid

KW - Animals

KW - Brain

KW - Humans

KW - Pain

KW - Placebos

KW - Predictive Value of Tests

U2 - 10.1016/j.neuron.2014.02.042

DO - 10.1016/j.neuron.2014.02.042

M3 - SCORING: Journal article

C2 - 24656247

VL - 81

SP - 1223

EP - 1239

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 6

ER -